SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yoa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		4 / 4 GLY A 154
ASP A 152
GLY A  16
THR A  32
 None
 0.90A 1hxbB-1yoaA:
undetectable		 1hxbB-1yoaA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 11 THR A  86
GLN A  80
ALA A  30
GLY A  31
THR A  32
 FAD  A 401 (-4.5A)
None
None
FAD  A 401 (-3.5A)
None
 1.13A 2f16H-1yoaA:
undetectable
2f16I-1yoaA:
undetectable		 2f16H-1yoaA:
22.27
2f16I-1yoaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 11 THR A  86
GLN A  80
ALA A  30
GLY A  31
THR A  32
 FAD  A 401 (-4.5A)
None
None
FAD  A 401 (-3.5A)
None
 1.13A 2f16V-1yoaA:
undetectable
2f16W-1yoaA:
undetectable		 2f16V-1yoaA:
22.27
2f16W-1yoaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A  31
PHE A  83
ALA A  22
THR A  21
ALA A  58
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.6A)
None
None
FAD  A 401 ( 3.7A)
 0.91A 3g88A-1yoaA:
undetectable		 3g88A-1yoaA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A  31
PHE A  83
ALA A  22
THR A  21
ALA A  58
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.6A)
None
None
FAD  A 401 ( 3.7A)
 0.92A 3g88B-1yoaA:
undetectable		 3g88B-1yoaA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  31
PHE A  83
ALA A  22
THR A  21
ALA A  58
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.6A)
None
None
FAD  A 401 ( 3.7A)
 0.89A 3g89A-1yoaA:
undetectable		 3g89A-1yoaA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A  31
PHE A  83
ALA A  22
THR A  21
ALA A  58
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.6A)
None
None
FAD  A 401 ( 3.7A)
 0.89A 3g89B-1yoaA:
undetectable		 3g89B-1yoaA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  31
PHE A  83
ALA A  22
THR A  21
ALA A  58
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.6A)
None
None
FAD  A 401 ( 3.7A)
 0.93A 3g8bA-1yoaA:
undetectable		 3g8bA-1yoaA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A  31
PHE A  83
ALA A  22
THR A  21
ALA A  58
 FAD  A 401 (-3.5A)
FAD  A 401 (-3.6A)
None
None
FAD  A 401 ( 3.7A)
 0.94A 3g8bB-1yoaA:
undetectable		 3g8bB-1yoaA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		3 / 3 MET A  69
MET A 150
PHE A  82
 None
FAD  A 401 (-4.8A)
None
 1.38A 3gn8A-1yoaA:
undetectable		 3gn8A-1yoaA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		4 / 4 GLY A 154
ASP A 152
GLY A  16
THR A  32
 None
 0.86A 3k4vC-1yoaA:
undetectable		 3k4vC-1yoaA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 11 THR A  86
GLN A  80
ALA A  30
GLY A  31
THR A  32
 FAD  A 401 (-4.5A)
None
None
FAD  A 401 (-3.5A)
None
 1.14A 3mg0H-1yoaA:
undetectable
3mg0I-1yoaA:
undetectable		 3mg0H-1yoaA:
22.27
3mg0I-1yoaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 11 THR A  86
GLN A  80
ALA A  30
GLY A  31
THR A  32
 FAD  A 401 (-4.5A)
None
None
FAD  A 401 (-3.5A)
None
 1.14A 3mg0V-1yoaA:
undetectable
3mg0W-1yoaA:
undetectable		 3mg0V-1yoaA:
22.27
3mg0W-1yoaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  46
LEU A 106
LEU A 116
VAL A  60
GLY A  64
 None
 0.99A 3pghC-1yoaA:
undetectable		 3pghC-1yoaA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  46
LEU A 106
LEU A 116
VAL A  60
GLY A  64
 None
 0.96A 3rr3C-1yoaA:
undetectable		 3rr3C-1yoaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  46
LEU A 106
LEU A 116
VAL A  60
GLY A  64
 None
 0.96A 3rr3D-1yoaA:
undetectable		 3rr3D-1yoaA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		3 / 3 PRO A  85
THR A  86
LEU A  56
 FAD  A 401 (-4.2A)
FAD  A 401 (-4.5A)
FAD  A 401 ( 4.5A)
 0.71A 3ttrA-1yoaA:
undetectable		 3ttrA-1yoaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 106
LEU A 116
ALA A  29
VAL A  60
GLY A  64
 None
None
FAD  A 401 (-3.1A)
None
None
 0.98A 5jw1B-1yoaA:
undetectable		 5jw1B-1yoaA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 THR A  86
GLN A  80
ALA A  30
GLY A  31
THR A  32
 FAD  A 401 (-4.5A)
None
None
FAD  A 401 (-3.5A)
None
 1.20A 5l5fH-1yoaA:
undetectable
5l5fI-1yoaA:
undetectable		 5l5fH-1yoaA:
23.29
5l5fI-1yoaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 THR A  86
GLN A  80
ALA A  30
GLY A  31
THR A  32
 FAD  A 401 (-4.5A)
None
None
FAD  A 401 (-3.5A)
None
 1.20A 5l5fV-1yoaA:
undetectable
5l5fW-1yoaA:
undetectable		 5l5fV-1yoaA:
23.29
5l5fW-1yoaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 THR A  86
GLN A  80
ALA A  30
GLY A  31
THR A  32
 FAD  A 401 (-4.5A)
None
None
FAD  A 401 (-3.5A)
None
 1.21A 5l66H-1yoaA:
undetectable
5l66I-1yoaA:
undetectable		 5l66H-1yoaA:
23.29
5l66I-1yoaA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1yoa PUTATIVE
FLAVOPROTEIN
(Thermus
thermophilus) 		5 / 12 THR A  86
GLN A  80
ALA A  30
GLY A  31
THR A  32
 FAD  A 401 (-4.5A)
None
None
FAD  A 401 (-3.5A)
None
 1.20A 5l66V-1yoaA:
undetectable
5l66W-1yoaA:
undetectable		 5l66V-1yoaA:
23.29
5l66W-1yoaA:
19.81