SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yp0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
4 / 7 LEU A 229
MET A 285
LEU A 231
GLN A 233
None
0.99A 1kt3A-1yp0A:
undetectable
1kt3A-1yp0A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
4 / 5 LEU A 375
TRP A 280
LEU A 227
GLN A 395
None
1.41A 1p93D-1yp0A:
21.5
1p93D-1yp0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
5 / 12 ALA A 270
ASP A 271
LEU A 307
ARG A 314
LEU A 438
PEF  A 201 ( 4.4A)
None
PEF  A 201 (-4.0A)
None
None
0.98A 2jfaB-1yp0A:
21.5
2jfaB-1yp0A:
28.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
4 / 7 ILE A 245
ARG A 314
LEU A 307
ASP A 310
None
None
PEF  A 201 (-4.0A)
None
1.04A 2qqcB-1yp0A:
undetectable
2qqcC-1yp0A:
undetectable
2qqcB-1yp0A:
23.71
2qqcC-1yp0A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
4 / 7 LEU A 307
ASP A 310
ILE A 245
ARG A 314
PEF  A 201 (-4.0A)
None
None
None
1.07A 2qqcI-1yp0A:
undetectable
2qqcL-1yp0A:
undetectable
2qqcI-1yp0A:
11.06
2qqcL-1yp0A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
3 / 3 ASN A 451
LEU A 249
PHE A 274
None
0.80A 4dajB-1yp0A:
undetectable
4dajB-1yp0A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
6 / 12 VAL A 278
GLN A 295
MET A 296
GLN A 300
GLU A 455
ALA A 459
None
0.99A 4ltwA-1yp0A:
22.8
4ltwA-1yp0A:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
3 / 3 ARG A 366
GLN A 317
GLU A 238
None
0.81A 4tvtA-1yp0A:
undetectable
4tvtA-1yp0A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
3 / 3 ASN A 451
LEU A 249
PHE A 274
None
0.77A 5dsgA-1yp0A:
undetectable
5dsgA-1yp0A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
5 / 12 LEU A 345
LEU A 438
ALA A 434
THR A 273
ALA A 270
PEF  A 201 (-4.2A)
None
PEF  A 201 ( 3.8A)
None
PEF  A 201 ( 4.4A)
1.09A 5mioB-1yp0A:
undetectable
5mioB-1yp0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1yp0 NUCLEAR RECEPTOR
SUBFAMILY 5, GROUP
A, MEMBER 1

(Mus
musculus)
4 / 8 GLY A 342
HIS A 346
VAL A 349
ALA A 261
PEF  A 201 (-3.5A)
None
PEF  A 201 ( 4.7A)
None
0.76A 6hu9H-1yp0A:
undetectable
6hu9e-1yp0A:
undetectable
6hu9H-1yp0A:
13.85
6hu9e-1yp0A:
20.75