SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ypf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		4 / 7 TYR A  56
ASN A  61
TYR A  62
LEU A  57
 None
 1.07A 1qzrA-1ypfA:
undetectable		 1qzrA-1ypfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		4 / 7 TYR A  56
ASN A  61
TYR A  62
LEU A  57
 None
 1.13A 1qzrB-1ypfA:
undetectable		 1qzrB-1ypfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		4 / 4 THR A 177
GLY A 187
ASP A   6
ALA A 192
 None
 1.19A 1sg9A-1ypfA:
undetectable		 1sg9A-1ypfA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		3 / 3 MET A  66
VAL A 143
GLU A  98
 None
 0.89A 2x9gA-1ypfA:
undetectable		 2x9gA-1ypfA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		5 / 12 PHE A  63
VAL A 127
LEU A 157
ILE A 117
THR A 165
 None
 1.28A 3em0B-1ypfA:
undetectable		 3em0B-1ypfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		5 / 11 ILE A 229
ALA A  43
PHE A 233
LEU A 286
VAL A  40
 None
 0.94A 3n0hA-1ypfA:
undetectable		 3n0hA-1ypfA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		4 / 5 LEU A  86
ALA A  88
THR A  55
PHE A  77
 None
 1.37A 3vasB-1ypfA:
undetectable		 3vasB-1ypfA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		6 / 9 ASN A 147
ILE A 169
GLY A 170
CYH A 175
THR A 177
ASP A 207
 None
 0.91A 4fxsA-1ypfA:
32.1		 4fxsA-1ypfA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		6 / 9 ASP A 118
ASN A 147
ILE A 169
GLY A 170
THR A 177
ASP A 207
 None
 0.43A 4fxsA-1ypfA:
32.1		 4fxsA-1ypfA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		4 / 7 ILE A  53
VAL A  41
SER A 239
ASP A 118
 None
 1.26A 4iarA-1ypfA:
undetectable		 4iarA-1ypfA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		4 / 5 TYR A  56
THR A 225
LEU A  31
MET A  66
 None
 1.26A 4mbsB-1ypfA:
undetectable		 4mbsB-1ypfA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		4 / 8 ILE A 119
GLY A  93
ASN A  44
PHE A 142
 None
 0.95A 5hieD-1ypfA:
undetectable		 5hieD-1ypfA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		3 / 3 ILE A 210
VAL A 227
PRO A  39
 None
 0.65A 5uunA-1ypfA:
undetectable		 5uunA-1ypfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 1ypf GMP REDUCTASE
(Bacillus
anthracis) 		5 / 12 ASP A  26
PHE A  36
ILE A  65
ILE A 204
ALA A 224
 None
 1.18A 5vc0A-1ypfA:
undetectable		 5vc0A-1ypfA:
21.44