SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ypx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 165
LEU A  79
ALA A 168
ILE A 266
MET A 236
 None
 1.08A 1crbA-1ypxA:
undetectable		 1crbA-1ypxA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		4 / 8 PHE A 161
TYR A 154
ILE A 105
LEU A 165
 None
 0.90A 1fslA-1ypxA:
undetectable		 1fslA-1ypxA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		4 / 8 GLY A  81
VAL A  82
GLU A  83
ILE A 109
 None
 0.92A 1pk7B-1ypxA:
undetectable		 1pk7B-1ypxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		4 / 6 HIS A 144
PHE A 161
ARG A 146
GLY A 147
 None
 1.40A 2i30A-1ypxA:
undetectable		 2i30A-1ypxA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 PHE A 270
ASP A 267
GLY A 268
SER A 331
ASP A  10
 None
 1.24A 2pgfA-1ypxA:
4.4		 2pgfA-1ypxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		4 / 7 GLN A 170
TYR A 169
TYR A 154
ILE A 105
 None
 1.31A 2ph9A-1ypxA:
undetectable
2ph9B-1ypxA:
undetectable		 2ph9A-1ypxA:
18.62
2ph9B-1ypxA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		4 / 6 PRO A 140
ALA A 224
LEU A 165
ALA A 162
 None
 0.97A 2vcvB-1ypxA:
undetectable		 2vcvB-1ypxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 8 LEU A 143
PRO A 140
ALA A 224
ALA A 172
PHE A  75
 None
 0.96A 2vcvF-1ypxA:
undetectable		 2vcvF-1ypxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		4 / 6 PRO A 140
ALA A 224
LEU A 165
ALA A 162
 None
 0.89A 2vcvK-1ypxA:
undetectable		 2vcvK-1ypxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 PRO A   6
GLY A 297
SER A 301
ILE A 312
LEU A 330
 None
 1.27A 3iv6A-1ypxA:
undetectable		 3iv6A-1ypxA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 PRO A   6
GLY A 297
SER A 301
ILE A 312
LEU A 330
 None
 1.11A 3iv6C-1ypxA:
undetectable		 3iv6C-1ypxA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 186
ALA A 224
ILE A 173
ALA A 172
ILE A 225
 None
 0.98A 4o2bD-1ypxA:
2.8		 4o2bD-1ypxA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 264
ILE A 225
LEU A 260
ASP A 188
SER A 190
 None
 1.33A 4r88A-1ypxA:
2.5		 4r88A-1ypxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 264
ILE A 225
LEU A 260
ASP A 188
SER A 190
 None
 1.33A 4r88B-1ypxA:
7.9		 4r88B-1ypxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 264
ILE A 225
LEU A 260
ASP A 188
SER A 190
 None
 1.34A 4r88C-1ypxA:
4.2		 4r88C-1ypxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 264
ILE A 225
LEU A 260
ASP A 188
SER A 190
 None
 1.37A 4r88D-1ypxA:
2.1		 4r88D-1ypxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 264
ILE A 225
LEU A 260
ASP A 188
SER A 190
 None
 1.33A 4r88E-1ypxA:
2.1		 4r88E-1ypxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 264
ILE A 225
LEU A 260
ASP A 188
SER A 190
 None
 1.32A 4r88F-1ypxA:
2.1		 4r88F-1ypxA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		3 / 3 THR A 303
ASP A 274
GLU A 272
 None
 0.68A 5fa8A-1ypxA:
1.0		 5fa8A-1ypxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		4 / 6 PHE A  66
GLU A 347
GLU A  55
VAL A  56
 None
 1.05A 5h4dA-1ypxA:
undetectable		 5h4dA-1ypxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 165
LEU A  79
ALA A 168
ILE A 266
MET A 236
 None
 1.05A 5h8tA-1ypxA:
undetectable		 5h8tA-1ypxA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 10 GLY A  81
VAL A  82
GLU A  83
ASP A 110
ILE A 109
 None
 1.10A 5i3cB-1ypxA:
undetectable		 5i3cB-1ypxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		4 / 8 ASN A  43
THR A  18
ILE A  41
GLY A  20
 None
 0.98A 5nzxA-1ypxA:
2.5		 5nzxA-1ypxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		4 / 7 ASN A  43
THR A  18
ILE A  41
GLY A  20
 None
 0.99A 5nzyA-1ypxA:
2.5		 5nzyA-1ypxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 ASP A 231
PHE A 176
ILE A 137
PHE A 111
ALA A 168
 None
 1.30A 5vcgA-1ypxA:
undetectable		 5vcgA-1ypxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1ypx PUTATIVE VITAMIN-B12
INDEPENDENT
METHIONINE SYNTHASE
FAMILY PROTEIN
(Listeria
monocytogenes) 		5 / 12 LEU A 186
ALA A 224
ILE A 173
ALA A 172
ILE A 225
 None
 0.97A 5xiwB-1ypxA:
3.3		 5xiwB-1ypxA:
13.35