SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ypz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 7 GLN E   6
THR E 112
SER E   7
TYR E  86
 None
 1.39A 1eiiA-1ypzE:
undetectable		 1eiiA-1ypzE:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 1ypz T-CELL RECEPTOR
GAMMA CHAIN
(Mus
musculus) 		4 / 6 PHE F 192
GLU F 155
LEU F 154
VAL F 164
 None
 1.07A 1hk1A-1ypzF:
undetectable		 1hk1A-1ypzF:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 8 THR E 135
GLY E 180
ILE E 159
VAL E 160
 None
 0.93A 1rxcB-1ypzE:
undetectable		 1rxcB-1ypzE:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 8 THR E 135
GLY E 180
ILE E 159
VAL E 160
 None
 0.97A 1rxcE-1ypzE:
undetectable		 1rxcE-1ypzE:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 8 THR E 135
GLY E 180
ILE E 159
VAL E 160
 None
 0.94A 1rxcI-1ypzE:
undetectable		 1rxcI-1ypzE:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 8 THR E 135
GLY E 180
ILE E 159
VAL E 160
 None
 0.94A 1rxcK-1ypzE:
undetectable		 1rxcK-1ypzE:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1ypz T-CELL RECEPTOR
GAMMA CHAIN
(Mus
musculus) 		3 / 3 PHE F 225
SER F 193
LEU F 153
 None
 0.80A 2w1bA-1ypzF:
undetectable		 2w1bA-1ypzF:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 1ypz T CELL RECEPTOR
DELTA
T-CELL RECEPTOR
GAMMA CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 7 PHE E  35
PHE F 109
PHE F 105
TYR E  48
 None
 1.22A 3hggA-1ypzE:
undetectable		 3hggA-1ypzE:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1ypz H2-T22 PROTEIN
(Mus
musculus) 		3 / 3 GLY A  26
ILE A  66
VAL A  67
 None
 0.46A 3nv6A-1ypzA:
undetectable		 3nv6A-1ypzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 1ypz T-CELL RECEPTOR
GAMMA CHAIN
(Mus
musculus) 		4 / 6 PHE F 157
ALA F 156
THR F 185
LEU F 153
 None
None
NAG  F 231 (-2.7A)
None
 1.00A 3t3zA-1ypzF:
undetectable		 3t3zA-1ypzF:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 1ypz T-CELL RECEPTOR
GAMMA CHAIN
(Mus
musculus) 		4 / 6 PHE F 157
ALA F 156
THR F 185
LEU F 153
 None
None
NAG  F 231 (-2.7A)
None
 1.00A 3t3zB-1ypzF:
undetectable		 3t3zB-1ypzF:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 1ypz T-CELL RECEPTOR
GAMMA CHAIN
(Mus
musculus) 		4 / 5 PHE F 157
ALA F 156
THR F 185
LEU F 153
 None
None
NAG  F 231 (-2.7A)
None
 0.93A 3t3zC-1ypzF:
undetectable		 3t3zC-1ypzF:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1ypz T-CELL RECEPTOR
GAMMA CHAIN
(Mus
musculus) 		4 / 6 PHE F 157
ALA F 156
THR F 185
LEU F 153
 None
None
NAG  F 231 (-2.7A)
None
 0.98A 3t3zD-1ypzF:
undetectable		 3t3zD-1ypzF:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1ypz H2-T22 PROTEIN
(Mus
musculus) 		3 / 3 PRO A 124
THR A 125
LEU A 116
 None
 0.68A 3ttrA-1ypzA:
undetectable		 3ttrA-1ypzA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 8 THR E 135
GLY E 180
ILE E 159
VAL E 160
 None
 0.96A 4e1vC-1ypzE:
undetectable		 4e1vC-1ypzE:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 8 THR E 135
GLY E 180
ILE E 159
VAL E 160
 None
 0.99A 4e1vD-1ypzE:
undetectable		 4e1vD-1ypzE:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 8 THR E 135
GLY E 180
ILE E 159
VAL E 160
 None
 0.94A 4e1vE-1ypzE:
undetectable		 4e1vE-1ypzE:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 8 THR E 135
GLY E 180
ILE E 159
VAL E 160
 None
 0.94A 4e1vG-1ypzE:
undetectable		 4e1vG-1ypzE:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		3 / 3 VAL E 137
GLY E 180
LYS E 178
 None
 0.50A 4k50A-1ypzE:
undetectable		 4k50A-1ypzE:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		3 / 3 VAL E 137
GLY E 180
LYS E 178
 None
 0.52A 4k50E-1ypzE:
undetectable		 4k50E-1ypzE:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		3 / 3 VAL E 137
GLY E 180
LYS E 178
 None
 0.50A 4k50I-1ypzE:
undetectable		 4k50I-1ypzE:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1ypz H2-T22 PROTEIN
(Mus
musculus) 		5 / 9 THR A  80
LEU A  81
GLN A  99
TYR A   9
LEU A  78
 None
 1.37A 4ltwA-1ypzA:
undetectable		 4ltwA-1ypzA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1ypz H2-T22 PROTEIN
(Mus
musculus) 		4 / 7 GLU A  40
SER A  37
ILE A  23
VAL A  25
 None
 1.13A 4tvtA-1ypzA:
undetectable		 4tvtA-1ypzA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1ypz H2-T22 PROTEIN
(Mus
musculus) 		4 / 4 LEU A 266
ILE A 213
HIS A 263
VAL A 261
 None
 1.25A 4xyzA-1ypzA:
undetectable		 4xyzA-1ypzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 1ypz T CELL RECEPTOR
DELTA
T-CELL RECEPTOR
GAMMA CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 4 SER E 169
SER E 175
GLU F 141
ASP E 143
 None
 1.28A 4ymgA-1ypzE:
0.0		 4ymgA-1ypzE:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ypz H2-T22 PROTEIN
T CELL RECEPTOR
DELTA
(Mus
musculus) 		4 / 7 THR A  80
LEU A  81
LEU E 101
THR E 103
 None
 0.92A 4z90A-1ypzA:
undetectable
4z90B-1ypzA:
undetectable
4z90C-1ypzA:
undetectable
4z90D-1ypzA:
undetectable
4z90E-1ypzA:
undetectable		 4z90A-1ypzA:
23.73
4z90B-1ypzA:
23.73
4z90C-1ypzA:
23.73
4z90D-1ypzA:
23.73
4z90E-1ypzA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1ypz T-CELL RECEPTOR
GAMMA CHAIN
(Mus
musculus) 		4 / 7 LEU F  86
VAL F 161
GLU F 213
SER F  10
 None
 1.31A 5umwA-1ypzF:
undetectable
5umwF-1ypzF:
undetectable		 5umwA-1ypzF:
16.16
5umwF-1ypzF:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1ypz T CELL RECEPTOR
DELTA
(Mus
musculus) 		3 / 3 ILE E 151
VAL E 141
PRO E 126
 None
 0.66A 5uunA-1ypzE:
undetectable		 5uunA-1ypzE:
20.91