SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		5 / 12 PHE A  60
LEU A  55
PHE A  22
ALA A  79
ALA A  73
 None
 1.20A 1q23A-1yq1A:
undetectable
1q23B-1yq1A:
undetectable		 1q23A-1yq1A:
23.89
1q23B-1yq1A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		4 / 7 ILE A  68
PHE A  22
LEU A  21
ILE A  57
 None
 0.92A 1yc2E-1yq1A:
undetectable		 1yc2E-1yq1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		4 / 8 ASN A 191
SER A 192
VAL A 163
PHE A 149
 None
 0.98A 2wekA-1yq1A:
undetectable		 2wekA-1yq1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		4 / 8 ASN A 191
SER A 192
VAL A 163
PHE A 149
 None
 0.97A 2wekB-1yq1A:
undetectable		 2wekB-1yq1A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		5 / 9 ILE A 196
GLY A 195
TYR A 193
GLY A  26
PHE A  78
 None
 1.27A 2y7wA-1yq1A:
1.1		 2y7wA-1yq1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		5 / 11 GLY A  80
PHE A 149
ASP A 159
ALA A 158
ILE A 151
 None
 1.29A 3id5B-1yq1A:
undetectable		 3id5B-1yq1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		5 / 11 GLY A  80
PHE A 149
ASP A 159
ALA A 158
ILE A 151
 None
 1.29A 3id5F-1yq1A:
undetectable		 3id5F-1yq1A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		4 / 5 PHE A 103
PHE A  99
PHE A 175
PHE A 135
 None
 1.28A 3ko0F-1yq1A:
undetectable
3ko0G-1yq1A:
undetectable		 3ko0F-1yq1A:
17.77
3ko0G-1yq1A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		4 / 5 PHE A 175
PHE A 135
PHE A 103
PHE A  99
 None
 1.18A 3ko0F-1yq1A:
undetectable
3ko0G-1yq1A:
undetectable		 3ko0F-1yq1A:
17.77
3ko0G-1yq1A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		5 / 7 LEU A 166
LEU A 186
SER A 192
ASN A 191
ASP A 159
 None
 1.45A 3lm8A-1yq1A:
undetectable
3lm8C-1yq1A:
undetectable		 3lm8A-1yq1A:
20.69
3lm8C-1yq1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		5 / 8 ASP A 159
LEU A 166
LEU A 186
SER A 192
ASN A 191
 None
 1.42A 3lm8A-1yq1A:
undetectable
3lm8C-1yq1A:
undetectable		 3lm8A-1yq1A:
20.69
3lm8C-1yq1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		5 / 8 ASP A 159
LEU A 166
LEU A 186
SER A 192
ASN A 191
 None
 1.45A 3lm8B-1yq1A:
undetectable
3lm8D-1yq1A:
undetectable		 3lm8B-1yq1A:
20.69
3lm8D-1yq1A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		4 / 5 LEU A 160
PRO A  17
LEU A  20
ILE A 196
 None
 0.98A 4klrA-1yq1A:
undetectable		 4klrA-1yq1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		5 / 11 ALA A  73
GLU A  86
SER A 153
ASP A 154
ILE A 155
 None
 1.20A 5i3cC-1yq1A:
undetectable		 5i3cC-1yq1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 1yq1 GLUTATHIONE
S-TRANSFERASE
(Caenorhabditis
elegans) 		4 / 4 PHE A  99
LEU A 141
LEU A 183
VAL A  92
 None
 1.32A 5xxiA-1yq1A:
undetectable		 5xxiA-1yq1A:
17.98