SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT
(Gallus
gallus) 		5 / 9 LEU B 203
LEU B 212
ALA B 187
LEU B 184
ALA B 234
 None
 0.96A 2vcvE-1yq3B:
undetectable		 2vcvE-1yq3B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT
(Gallus
gallus) 		5 / 9 LEU B 203
LEU B 212
ALA B 187
LEU B 184
ALA B 234
 None
 1.03A 2vcvH-1yq3B:
undetectable		 2vcvH-1yq3B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT
(Gallus
gallus) 		4 / 6 LEU B 203
ALA B 187
LEU B 184
ALA B 234
 None
 0.92A 2vcvK-1yq3B:
undetectable		 2vcvK-1yq3B:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT
(Gallus
gallus) 		5 / 9 ALA B 162
ALA B 182
LEU B 229
LEU B 160
SER B  72
 None
SF4  B1003 ( 3.7A)
SF4  B1003 ( 4.7A)
None
FES  B1002 ( 4.6A)
 1.13A 4or0B-1yq3B:
undetectable		 4or0B-1yq3B:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_D_EVPD102_1
(DNA TOPOISOMERASE
2-ALPHA)		 1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT
(Gallus
gallus) 		4 / 4 GLY B 175
ASP B 176
ARG B 214
MET B 191
 None
 1.00A 5gwkB-1yq3B:
0.0		 5gwkB-1yq3B:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT
(Gallus
gallus) 		4 / 7 ILE B  77
GLY B  80
PHE B 118
CYH B  85
 None
None
None
FES  B1002 (-2.2A)
 0.82A 5hieA-1yq3B:
undetectable		 5hieA-1yq3B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1yq3 SUCCINATE
DEHYDROGENASE IP
SUBUNIT
(Gallus
gallus) 		3 / 3 TRP B 190
ILE B 192
ASP B 193
 None
 0.82A 6i0y7-1yq3B:
undetectable		 6i0y7-1yq3B:
11.85