SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yq9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4F_C_ADNC603_2 (S-ADENOSYLHOMOCYSTEI NE HYDROLASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 5	GLU A 22 THR A 18 HIS A 13 LEU A 48	None	1.20A	1d4fC-1yq9A: 4.8	1d4fC-1yq9A: 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FK9_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.13A	1fk9A-1yq9A: undetectable	1fk9A-1yq9A: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKO_A_EFZA999_1 (HIV-1 RT, A-CHAIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.23A	1fkoA-1yq9A: undetectable	1fkoA-1yq9A: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FKP_A_NVPA999_1 (HIV-1 RT, A-CHAIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 11	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.17A	1fkpA-1yq9A: undetectable	1fkpA-1yq9A: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKV_A_EFZA2000_1 (POL POLYPROTEIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 9	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.20A	1ikvA-1yq9A: undetectable	1ikvA-1yq9A: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JKH_A_EFZA999_1 (HIV-1 RT, A-CHAIN HIV-1 RT, B-CHAIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 11	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.18A	1jkhA-1yq9A: undetectable 1jkhB-1yq9A: undetectable	1jkhA-1yq9A: 19.44 1jkhB-1yq9A: 19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JLB_A_NVPA999_1 (HIV-1 RT A-CHAIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 8	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.17A	1jlbA-1yq9A: undetectable	1jlbA-1yq9A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_B_SAMB1293_0 (GLYCINE N-METHYLTRANSFERASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 12	ILE A 72 GLY A 116 VAL A 131 ALA A 121 GLY A 110	None H2S A1268 ( 4.4A) None None SF4 A 267 ( 3.7A)	1.17A	1kiaB-1yq9A: undetectable	1kiaB-1yq9A: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LW0_A_NVPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.12A	1lw0A-1yq9A: undetectable	1lw0A-1yq9A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LWC_A_NVPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 11	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.13A	1lwcA-1yq9A: undetectable	1lwcA-1yq9A: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LWF_A_NVPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 9	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.18A	1lwfA-1yq9A: undetectable	1lwfA-1yq9A: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VRT_A_NVPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 9	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.16A	1vrtA-1yq9A: undetectable	1vrtA-1yq9A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_A_SAMA3142_0 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 12	GLY A 74 GLY A 75 GLY A 130 PHE A 155 HIS A 13	SF4 A 267 ( 4.9A) None None None None	1.04A	1wg8A-1yq9A: undetectable	1wg8A-1yq9A: 23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_B_SAMB3141_0 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 12	GLY A 74 GLY A 75 GLY A 130 PHE A 155 HIS A 13	SF4 A 267 ( 4.9A) None None None None	0.99A	1wg8B-1yq9A: undetectable	1wg8B-1yq9A: 23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HND_A_NVPA999_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.14A	2hndA-1yq9A: undetectable	2hndA-1yq9A: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HNY_A_NVPA999_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.13A	2hnyA-1yq9A: undetectable	2hnyA-1yq9A: 19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q63_A_1UNA1001_4 (PROTEASE RETROPEPSIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	3 / 3	ASP A 256 ASN A 253 THR A 114	None	0.77A	2q63B-1yq9A: undetectable	2q63B-1yq9A: 17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AVP_A_MV2A313_1 (PANTOTHENATE KINASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 7	VAL A 24 HIS A 13 LEU A 25 ILE A 40	None	1.04A	3avpA-1yq9A: undetectable	3avpA-1yq9A: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_A_H3PA552_1 (GLUTAMATE DEHYDROGENASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 6	ILE A 95 TYR A 93 ILE A 72 HIS A 13	None	1.03A	3eteA-1yq9A: undetectable 3eteE-1yq9A: undetectable	3eteA-1yq9A: 19.68 3eteE-1yq9A: 19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_C_H3PC554_1 (GLUTAMATE DEHYDROGENASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 5	ILE A 95 TYR A 93 ILE A 72 HIS A 13	None	1.03A	3eteB-1yq9A: undetectable 3eteC-1yq9A: undetectable	3eteB-1yq9A: 19.68 3eteC-1yq9A: 19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ETE_F_H3PF552_1 (GLUTAMATE DEHYDROGENASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 7	ILE A 72 HIS A 13 ILE A 95 TYR A 93	None	1.03A	3eteD-1yq9A: undetectable 3eteF-1yq9A: undetectable	3eteD-1yq9A: 19.68 3eteF-1yq9A: 19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FXR_A_ASCA3001_0 (LYSR TYPE REGULATOR OF TSAMBCD)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 8	ALA A 142 ILE A 143 ASN A 144 PRO A 176 PRO A 168	None	1.27A	3fxrA-1yq9A: undetectable	3fxrA-1yq9A: 22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HVT_A_NVPA557_1 (HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66))	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 9	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.22A	3hvtA-1yq9A: undetectable	3hvtA-1yq9A: 19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LP0_A_NVPA701_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 9	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.20A	3lp0A-1yq9A: 0.0	3lp0A-1yq9A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LP1_A_NVPA701_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.17A	3lp1A-1yq9A: undetectable	3lp1A-1yq9A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QIP_A_NVPA561_1 (REVERSE HIV-1 REVERSE TRANSCRIPTASE P66)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.21A	3qipA-1yq9A: 0.0	3qipA-1yq9A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_C_RTZC2_1 (CYTOCHROME P450 2D6)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	THR A 47 LEU A 25 THR A 27 VAL A 32 VAL A 9	None	1.20A	3tbgC-1yq9A: undetectable	3tbgC-1yq9A: 21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3O_A_EFZA1557_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 9	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.25A	4b3oA-1yq9A: 0.0	4b3oA-1yq9A: 19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HBM_A_NVPA601_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 11	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.24A	5hbmA-1yq9A: undetectable	5hbmA-1yq9A: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I8F_A_ML1A211_1 (PHENOLIC OXIDATIVE COUPLING PROTEIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 6	VAL A 99 LYS A 102 ALA A 103 VAL A 10	None GOL A1273 (-4.1A) None None	0.84A	5i8fA-1yq9A: undetectable	5i8fA-1yq9A: 20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IWU_A_ACTA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 6	PHE A 155 VAL A 156 MET A 42 ILE A 40	None	1.13A	5iwuA-1yq9A: undetectable	5iwuA-1yq9A: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JH7_B_6K9B503_0 (TUBULIN BETA-2B CHAIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 11	VAL A 24 SER A 21 THR A 18 GLU A 73 LEU A 35	None None None SF4 A 267 ( 4.9A) None	1.26A	5jh7B-1yq9A: 3.2	5jh7B-1yq9A: 19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JH7_D_6K9D502_0 (TUBULIN BETA-2B CHAIN)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 11	VAL A 24 SER A 21 THR A 18 GLU A 73 LEU A 35	None None None SF4 A 267 ( 4.9A) None	1.27A	5jh7D-1yq9A: 3.2	5jh7D-1yq9A: 19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OCS_A_ACTA402_0 (PUTATIVE NADH-DEPENTDENT FLAVIN OXIDOREDUCTASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 5	CYH A 20 ILE A 109 HIS A 13 HIS A 45	SF4 A 267 (-2.3A) None None None	1.35A	5ocsA-1yq9A: undetectable	5ocsA-1yq9A: 22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OCS_A_ACTA402_0 (PUTATIVE NADH-DEPENTDENT FLAVIN OXIDOREDUCTASE)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 5	CYH A 20 ILE A 109 HIS A 13 TYR A 11	SF4 A 267 (-2.3A) None None None	1.23A	5ocsA-1yq9A: undetectable	5ocsA-1yq9A: 22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YSI_A_NCAA1001_0 (UBIQUITINATING/DEUBI QUITINATING ENZYME SDEA)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	4 / 6	ARG A 26 SER A 23 THR A 27 VAL A 32	None	1.22A	5ysiA-1yq9A: undetectable	5ysiA-1yq9A: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSI_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.27A	6bsiA-1yq9A: undetectable	6bsiA-1yq9A: 16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BSJ_A_EFZA601_1 (REVERSE TRANSCRIPTASE P66 SUBUNIT)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 10	LEU A 60 VAL A 87 GLY A 88 LEU A 12 TYR A 44	GOL A1272 (-4.0A) None GOL A1271 (-3.8A) None None	1.20A	6bsjA-1yq9A: undetectable	6bsjA-1yq9A: 16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NJ9_K_SAMK500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	1yq9	PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT (Desulfovibrio gigas)	5 / 12	PRO A 252 GLY A 110 GLY A 130 GLY A 75 ALA A 120	None SF4 A 267 ( 3.7A) None None None	1.02A	6nj9K-1yq9A: undetectable	6nj9K-1yq9A: 19.72

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D4F_C_ADNC603_2","S-ADENOSYLHOMOCYSTEINE HYDROLASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"GLU A  22;THR A  18;HIS A  13;LEU A  48","None","1.20A","1d4fC-1yq9A:4.8","1d4fC-1yq9A:20.96"],["1FK9_A_EFZA999_1","HIV-1 RT, A-CHAIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.13A","1fk9A-1yq9A:undetectable","1fk9A-1yq9A:19.69"],["1FKO_A_EFZA999_1","HIV-1 RT, A-CHAIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.23A","1fkoA-1yq9A:undetectable","1fkoA-1yq9A:19.69"],["1FKP_A_NVPA999_1","HIV-1 RT, A-CHAIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.17A","1fkpA-1yq9A:undetectable","1fkpA-1yq9A:19.69"],["1IKV_A_EFZA2000_1","POL POLYPROTEIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.20A","1ikvA-1yq9A:undetectable","1ikvA-1yq9A:19.14"],["1JKH_A_EFZA999_1","HIV-1 RT, A-CHAIN;HIV-1 RT, B-CHAIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.18A","1jkhA-1yq9A:undetectable;1jkhB-1yq9A:undetectable","1jkhA-1yq9A:19.44;1jkhB-1yq9A:19.18"],["1JLB_A_NVPA999_1","HIV-1 RT A-CHAIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.17A","1jlbA-1yq9A:undetectable","1jlbA-1yq9A:19.44"],["1KIA_B_SAMB1293_0","GLYCINE N-METHYLTRANSFERASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"ILE A  72;GLY A 116;VAL A 131;ALA A 121;GLY A 110","None;H2S A1268 ( 4.4A);None;None;SF4 A 267 ( 3.7A)","1.17A","1kiaB-1yq9A:undetectable","1kiaB-1yq9A:22.39"],["1LW0_A_NVPA999_1","HIV-1 REVERSE TRANSCRIPTASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.12A","1lw0A-1yq9A:undetectable","1lw0A-1yq9A:19.44"],["1LWC_A_NVPA999_1","HIV-1 REVERSE TRANSCRIPTASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.13A","1lwcA-1yq9A:undetectable","1lwcA-1yq9A:19.25"],["1LWF_A_NVPA999_1","HIV-1 REVERSE TRANSCRIPTASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.18A","1lwfA-1yq9A:undetectable","1lwfA-1yq9A:19.25"],["1VRT_A_NVPA999_1","HIV-1 REVERSE TRANSCRIPTASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.16A","1vrtA-1yq9A:undetectable","1vrtA-1yq9A:19.44"],["1WG8_A_SAMA3142_0","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"GLY A  74;GLY A  75;GLY A 130;PHE A 155;HIS A  13","SF4 A 267 ( 4.9A);None;None;None;None","1.04A","1wg8A-1yq9A:undetectable","1wg8A-1yq9A:23.55"],["1WG8_B_SAMB3141_0","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"GLY A  74;GLY A  75;GLY A 130;PHE A 155;HIS A  13","SF4 A 267 ( 4.9A);None;None;None;None","0.99A","1wg8B-1yq9A:undetectable","1wg8B-1yq9A:23.55"],["2HND_A_NVPA999_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.14A","2hndA-1yq9A:undetectable","2hndA-1yq9A:19.69"],["2HNY_A_NVPA999_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.13A","2hnyA-1yq9A:undetectable","2hnyA-1yq9A:19.69"],["2Q63_A_1UNA1001_4","PROTEASE RETROPEPSIN;PROTEASE RETROPEPSIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",3,"ASP A 256;ASN A 253;THR A 114","None","0.77A","2q63B-1yq9A:undetectable","2q63B-1yq9A:17.83"],["3AVP_A_MV2A313_1","PANTOTHENATE KINASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"VAL A  24;HIS A  13;LEU A  25;ILE A  40","None","1.04A","3avpA-1yq9A:undetectable","3avpA-1yq9A:21.01"],["3ETE_A_H3PA552_1","GLUTAMATE DEHYDROGENASE;GLUTAMATE DEHYDROGENASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"ILE A  95;TYR A  93;ILE A  72;HIS A  13","None","1.03A","3eteA-1yq9A:undetectable;3eteE-1yq9A:undetectable","3eteA-1yq9A:19.68;3eteE-1yq9A:19.68"],["3ETE_C_H3PC554_1","GLUTAMATE DEHYDROGENASE;GLUTAMATE DEHYDROGENASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"ILE A  95;TYR A  93;ILE A  72;HIS A  13","None","1.03A","3eteB-1yq9A:undetectable;3eteC-1yq9A:undetectable","3eteB-1yq9A:19.68;3eteC-1yq9A:19.68"],["3ETE_F_H3PF552_1","GLUTAMATE DEHYDROGENASE;GLUTAMATE DEHYDROGENASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"ILE A  72;HIS A  13;ILE A  95;TYR A  93","None","1.03A","3eteD-1yq9A:undetectable;3eteF-1yq9A:undetectable","3eteD-1yq9A:19.68;3eteF-1yq9A:19.68"],["3FXR_A_ASCA3001_0","LYSR TYPE REGULATOR OF TSAMBCD","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"ALA A 142;ILE A 143;ASN A 144;PRO A 176;PRO A 168","None","1.27A","3fxrA-1yq9A:undetectable","3fxrA-1yq9A:22.15"],["3HVT_A_NVPA557_1","HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66)","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.22A","3hvtA-1yq9A:undetectable","3hvtA-1yq9A:19.07"],["3LP0_A_NVPA701_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.20A","3lp0A-1yq9A:0.0","3lp0A-1yq9A:19.44"],["3LP1_A_NVPA701_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.17A","3lp1A-1yq9A:undetectable","3lp1A-1yq9A:19.44"],["3QIP_A_NVPA561_1","REVERSE HIV-1 REVERSE TRANSCRIPTASE P66","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.21A","3qipA-1yq9A:0.0","3qipA-1yq9A:19.44"],["3TBG_C_RTZC2_1","CYTOCHROME P450 2D6","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"THR A  47;LEU A  25;THR A  27;VAL A  32;VAL A   9","None","1.20A","3tbgC-1yq9A:undetectable","3tbgC-1yq9A:21.09"],["4B3O_A_EFZA1557_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.25A","4b3oA-1yq9A:0.0","4b3oA-1yq9A:19.44"],["5HBM_A_NVPA601_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.24A","5hbmA-1yq9A:undetectable","5hbmA-1yq9A:18.91"],["5I8F_A_ML1A211_1","PHENOLIC OXIDATIVE COUPLING PROTEIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"VAL A  99;LYS A 102;ALA A 103;VAL A  10","None;GOL A1273 (-4.1A);None;None","0.84A","5i8fA-1yq9A:undetectable","5i8fA-1yq9A:20.51"],["5IWU_A_ACTA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE II","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"PHE A 155;VAL A 156;MET A  42;ILE A  40","None","1.13A","5iwuA-1yq9A:undetectable","5iwuA-1yq9A:21.54"],["5JH7_B_6K9B503_0","TUBULIN BETA-2B CHAIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"VAL A  24;SER A  21;THR A  18;GLU A  73;LEU A  35","None;None;None;SF4 A 267 ( 4.9A);None","1.26A","5jh7B-1yq9A:3.2","5jh7B-1yq9A:19.52"],["5JH7_D_6K9D502_0","TUBULIN BETA-2B CHAIN","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"VAL A  24;SER A  21;THR A  18;GLU A  73;LEU A  35","None;None;None;SF4 A 267 ( 4.9A);None","1.27A","5jh7D-1yq9A:3.2","5jh7D-1yq9A:19.52"],["5OCS_A_ACTA402_0","PUTATIVE NADH-DEPENTDENT FLAVIN OXIDOREDUCTASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"CYH A  20;ILE A 109;HIS A  13;HIS A  45","SF4 A 267 (-2.3A);None;None;None","1.35A","5ocsA-1yq9A:undetectable","5ocsA-1yq9A:22.74"],["5OCS_A_ACTA402_0","PUTATIVE NADH-DEPENTDENT FLAVIN OXIDOREDUCTASE","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"CYH A  20;ILE A 109;HIS A  13;TYR A  11","SF4 A 267 (-2.3A);None;None;None","1.23A","5ocsA-1yq9A:undetectable","5ocsA-1yq9A:22.74"],["5YSI_A_NCAA1001_0","UBIQUITINATING\/DEUBIQUITINATING ENZYME SDEA","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",4,"ARG A  26;SER A  23;THR A  27;VAL A  32","None","1.22A","5ysiA-1yq9A:undetectable","5ysiA-1yq9A:19.25"],["6BSI_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.27A","6bsiA-1yq9A:undetectable","6bsiA-1yq9A:16.33"],["6BSJ_A_EFZA601_1","REVERSE TRANSCRIPTASE P66 SUBUNIT","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"LEU A  60;VAL A  87;GLY A  88;LEU A  12;TYR A  44","GOL A1272 (-4.0A);None;GOL A1271 (-3.8A);None;None","1.20A","6bsjA-1yq9A:undetectable","6bsjA-1yq9A:16.33"],["6NJ9_K_SAMK500_0","HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC","1yq9","PERIPLASMIC [NIFE] HYDROGENASE SMALL SUBUNIT","Desulfovibrio gigas",5,"PRO A 252;GLY A 110;GLY A 130;GLY A  75;ALA A 120","None;SF4 A 267 ( 3.7A);None;None;None","1.02A","6nj9K-1yq9A:undetectable","6nj9K-1yq9A:19.72"]]