SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 7 SER A 148
PRO A 147
SER A 145
ALA A 106
 None
 0.98A 1k5qA-1yqeA:
undetectable
1k5qB-1yqeA:
1.0		 1k5qA-1yqeA:
21.65
1k5qB-1yqeA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.94A 1v7zA-1yqeA:
2.6		 1v7zA-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.94A 1v7zB-1yqeA:
2.6		 1v7zB-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.95A 1v7zC-1yqeA:
2.6		 1v7zC-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.95A 1v7zD-1yqeA:
2.6		 1v7zD-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.96A 1v7zE-1yqeA:
2.5		 1v7zE-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.94A 1v7zF-1yqeA:
2.6		 1v7zF-1yqeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		5 / 12 SER A 234
ALA A 106
GLY A  91
LEU A 105
PHE A 214
 None
 1.18A 1vpoH-1yqeA:
undetectable
1vpoL-1yqeA:
undetectable		 1vpoH-1yqeA:
21.75
1vpoL-1yqeA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		3 / 3 ASP A  10
GLU A 135
TYR A 116
 None
 0.66A 1wsvA-1yqeA:
undetectable		 1wsvA-1yqeA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 4 GLY A  81
SER A  78
ILE A  84
HIS A  76
 None
None
None
POP  A3000 (-3.8A)
 1.14A 1yajJ-1yqeA:
2.1		 1yajJ-1yqeA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		5 / 10 ALA A 196
ALA A 215
THR A 218
LEU A 222
VAL A  93
 None
 1.41A 2wuzA-1yqeA:
undetectable		 2wuzA-1yqeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		5 / 10 ALA A 196
ALA A 215
THR A 218
LEU A 222
VAL A  93
 None
 1.41A 2wuzB-1yqeA:
undetectable		 2wuzB-1yqeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLY A  99
HIS A 139
ILE A 144
ALA A  96
 None
POP  A3000 (-4.3A)
None
None
 0.93A 2x0pA-1yqeA:
undetectable		 2x0pA-1yqeA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 8 GLU A 135
HIS A  88
HIS A  76
HIS A 138
 None
None
POP  A3000 (-3.8A)
None
 0.94A 3a6jC-1yqeA:
2.6		 3a6jC-1yqeA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		3 / 3 GLU A 143
SER A  90
VAL A  89
 None
 0.82A 3eeoA-1yqeA:
undetectable		 3eeoA-1yqeA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 7 VAL A   5
LEU A 174
MET A 173
ILE A  70
 None
 1.00A 3gp0A-1yqeA:
undetectable		 3gp0A-1yqeA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 7 PHE A 219
VAL A 250
VAL A 254
VAL A 231
 None
 0.90A 3hs6B-1yqeA:
undetectable		 3hs6B-1yqeA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		5 / 11 ASP A  18
GLU A  46
TYR A  37
LEU A  20
ILE A  44
 None
 1.44A 3o94A-1yqeA:
undetectable		 3o94A-1yqeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		5 / 11 ASP A  18
GLU A  46
TYR A  37
LEU A  20
ILE A  44
 None
 1.43A 3o94B-1yqeA:
undetectable		 3o94B-1yqeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		5 / 11 ASP A  18
GLU A  46
TYR A  37
LEU A  20
ILE A  44
 None
 1.43A 3o94C-1yqeA:
undetectable		 3o94C-1yqeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		5 / 11 ASP A  18
GLU A  46
TYR A  37
LEU A  20
ILE A  44
 None
 1.43A 3o94D-1yqeA:
undetectable		 3o94D-1yqeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 6 ILE A 239
PHE A 210
ALA A 187
ASN A 213
 None
 1.07A 3pgyA-1yqeA:
undetectable
3pgyB-1yqeA:
undetectable		 3pgyA-1yqeA:
22.36
3pgyB-1yqeA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		5 / 11 ALA A 236
ILE A 202
GLY A 189
THR A 137
VAL A  89
 None
 1.21A 3rukD-1yqeA:
undetectable		 3rukD-1yqeA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 5 TYR A  37
GLU A  46
LEU A  21
GLN A  14
 None
 1.43A 4qztB-1yqeA:
undetectable		 4qztB-1yqeA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625
(Archaeoglobus
fulgidus) 		4 / 7 ILE A  84
HIS A  76
GLY A  81
LYS A  79
 None
POP  A3000 (-3.8A)
None
None
 0.86A 4z69A-1yqeA:
undetectable		 4z69A-1yqeA:
21.06