SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yqq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 10 GLY A 119
PHE A 196
GLU A 197
VAL A 213
GLY A 214
MET A 215
THR A 238
ASN A 239
 GUN  A 400 (-3.5A)
None
GUN  A 400 (-2.8A)
GUN  A 400 ( 4.7A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.7A)
GUN  A 400 (-3.2A)
 0.56A 1pwyE-1yqqA:
36.2		 1pwyE-1yqqA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		7 / 10 PHE A 196
GLU A 197
VAL A 213
GLY A 214
MET A 215
THR A 238
HIS A 251
 None
GUN  A 400 (-2.8A)
GUN  A 400 ( 4.7A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.7A)
None
 0.86A 1pwyE-1yqqA:
36.2		 1pwyE-1yqqA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 10 GLY A 119
PHE A 196
GLU A 197
VAL A 213
GLY A 214
MET A 215
THR A 238
ASN A 239
 GUN  A 400 (-3.5A)
None
GUN  A 400 (-2.8A)
GUN  A 400 ( 4.7A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.7A)
GUN  A 400 (-3.2A)
 0.45A 1v3qE-1yqqA:
36.2		 1v3qE-1yqqA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		8 / 10 GLY A 119
PHE A 196
GLU A 197
VAL A 213
GLY A 214
MET A 215
THR A 238
HIS A 251
 GUN  A 400 (-3.5A)
None
GUN  A 400 (-2.8A)
GUN  A 400 ( 4.7A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.7A)
None
 0.70A 1v3qE-1yqqA:
36.2		 1v3qE-1yqqA:
42.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 11 GLY A 214
SER A 190
GLU A 197
ILE A 202
ALA A 241
 GUN  A 400 (-3.5A)
None
GUN  A 400 (-2.8A)
None
GUN  A 400 ( 4.6A)
 1.44A 2a58A-1yqqA:
3.9
2a58E-1yqqA:
3.8		 2a58A-1yqqA:
22.46
2a58E-1yqqA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 11 ILE A 202
ALA A 241
GLY A 214
SER A 190
GLU A 197
 None
GUN  A 400 ( 4.6A)
GUN  A 400 (-3.5A)
None
GUN  A 400 (-2.8A)
 1.43A 2a58C-1yqqA:
3.3
2a58D-1yqqA:
3.0		 2a58C-1yqqA:
22.46
2a58D-1yqqA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 ALA A  66
ALA A  40
LEU A  32
ILE A  43
PHE A  57
 None
 1.11A 2h77A-1yqqA:
undetectable		 2h77A-1yqqA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 8 THR A 139
VAL A 189
GLU A 201
PRO A 192
 None
 0.98A 2v41C-1yqqA:
undetectable
2v41D-1yqqA:
undetectable		 2v41C-1yqqA:
23.49
2v41D-1yqqA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 MET A 140
GLU A 197
ASN A 239
 None
GUN  A 400 (-2.8A)
GUN  A 400 (-3.2A)
 1.08A 3a27A-1yqqA:
undetectable		 3a27A-1yqqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 LEU A  32
LEU A  74
PHE A 272
LEU A 172
LEU A 130
 None
 1.39A 3adsA-1yqqA:
undetectable		 3adsA-1yqqA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 6 GLY A 119
GLU A 197
GLY A 214
MET A 215
ASN A 239
 GUN  A 400 (-3.5A)
GUN  A 400 (-2.8A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.2A)
 0.71A 3e9rA-1yqqA:
36.6		 3e9rA-1yqqA:
42.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 GLY A 119
GLU A 197
GLY A 214
MET A 215
 GUN  A 400 (-3.5A)
GUN  A 400 (-2.8A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
 0.44A 3e9rC-1yqqA:
36.5		 3e9rC-1yqqA:
42.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 6 GLY A 119
GLY A 214
MET A 215
ASN A 239
 GUN  A 400 (-3.5A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.2A)
 0.57A 3e9rC-1yqqA:
36.5		 3e9rC-1yqqA:
42.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 12 SER A  34
TYR A  89
ALA A 117
GLY A 119
GLU A 197
VAL A 213
GLY A 214
MET A 215
ASN A 239
HIS A 251
 PO4  A 500 (-3.3A)
None
PO4  A 500 ( 3.9A)
GUN  A 400 (-3.5A)
GUN  A 400 (-2.8A)
GUN  A 400 ( 4.7A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.2A)
None
 0.54A 3f8wA-1yqqA:
37.3		 3f8wA-1yqqA:
42.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 12 SER A  34
HIS A  87
TYR A  89
GLY A 119
GLU A 197
VAL A 213
GLY A 214
MET A 215
ASN A 239
HIS A 251
 PO4  A 500 (-3.3A)
PO4  A 500 (-3.8A)
None
GUN  A 400 (-3.5A)
GUN  A 400 (-2.8A)
GUN  A 400 ( 4.7A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.2A)
None
 0.56A 3f8wB-1yqqA:
39.0		 3f8wB-1yqqA:
42.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 TYR A  89
VAL A 213
GLY A 214
MET A 215
HIS A  65
 None
GUN  A 400 ( 4.7A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
PO4  A 500 (-4.1A)
 1.41A 3f8wB-1yqqA:
39.0		 3f8wB-1yqqA:
42.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		10 / 12 SER A  34
HIS A  87
TYR A  89
ALA A 117
GLY A 119
GLU A 197
VAL A 213
GLY A 214
MET A 215
ASN A 239
 PO4  A 500 (-3.3A)
PO4  A 500 (-3.8A)
None
PO4  A 500 ( 3.9A)
GUN  A 400 (-3.5A)
GUN  A 400 (-2.8A)
GUN  A 400 ( 4.7A)
GUN  A 400 (-3.5A)
GUN  A 400 (-4.1A)
GUN  A 400 (-3.2A)
 0.49A 3f8wC-1yqqA:
37.0		 3f8wC-1yqqA:
42.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 MET A 140
PRO A 144
GLY A  86
VAL A  62
ASN A 116
 None
 1.05A 3jb2A-1yqqA:
0.0		 3jb2A-1yqqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 8 PRO A 144
HIS A 226
ILE A 101
ARG A 102
 None
 1.10A 3sfeB-1yqqA:
undetectable
3sfeC-1yqqA:
undetectable		 3sfeB-1yqqA:
20.07
3sfeC-1yqqA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 PRO A  10
THR A 103
LEU A  54
 None
 0.73A 3ttrA-1yqqA:
undetectable		 3ttrA-1yqqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 ALA A  66
ALA A  40
LEU A  32
ILE A  43
PHE A  57
 None
 1.12A 4lnwA-1yqqA:
undetectable		 4lnwA-1yqqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 ALA A  66
ALA A  40
LEU A  32
ILE A  43
PHE A  57
 None
 1.12A 4lnxA-1yqqA:
undetectable		 4lnxA-1yqqA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 SER A  50
ALA A  48
VAL A  47
 None
 0.61A 4o2bC-1yqqA:
undetectable		 4o2bC-1yqqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 12 ASN A 195
GLY A 214
ILE A 137
ASN A 138
GLY A 210
 None
GUN  A 400 (-3.5A)
None
None
None
 0.92A 4obwC-1yqqA:
undetectable		 4obwC-1yqqA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 SER A  50
ALA A  48
VAL A  47
 None
 0.57A 4x1iA-1yqqA:
undetectable		 4x1iA-1yqqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		3 / 3 SER A  50
ALA A  48
VAL A  47
 None
 0.55A 5eypA-1yqqA:
3.4		 5eypA-1yqqA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 8 ALA A  29
VAL A  80
LEU A  71
ILE A  14
 None
 0.83A 5nujA-1yqqA:
undetectable		 5nujA-1yqqA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		4 / 7 GLN A  42
LEU A  39
ALA A 258
LEU A 260
 None
 1.03A 5nwvA-1yqqA:
undetectable		 5nwvA-1yqqA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 1yqq XANTHOSINE
PHOSPHORYLASE
(Escherichia
coli) 		5 / 11 PHE A 188
SER A 216
ARG A  85
THR A 254
ALA A 258
 None
PO4  A 500 (-2.4A)
PO4  A 500 (-4.2A)
GUN  A 400 (-3.4A)
None
 1.41A 6efnA-1yqqA:
undetectable		 6efnA-1yqqA:
21.52