SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yr0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 10 ALA A  10
ASP A  14
ILE A  61
ILE A 100
THR A  11
 None
None
None
SO4  A1001 (-4.6A)
None
 1.18A 2w9sC-1yr0A:
undetectable		 2w9sC-1yr0A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		5 / 12 MET A 105
LEU A 108
ALA A 112
HIS A 135
LEU A 166
 None
 1.18A 4zn7A-1yr0A:
undetectable		 4zn7A-1yr0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 6 ASP A  13
ASP A  39
ARG A  43
ASN A  23
 None
None
SO4  A1002 (-3.7A)
None
 1.13A 5l6eA-1yr0A:
undetectable		 5l6eA-1yr0A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 7 HIS A  87
HIS A 135
LEU A 138
SER A 131
 None
 0.99A 5m8rA-1yr0A:
undetectable		 5m8rA-1yr0A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 8 HIS A  87
HIS A 135
LEU A 138
SER A 131
 None
 0.98A 5m8rB-1yr0A:
undetectable		 5m8rB-1yr0A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 8 HIS A  87
HIS A 135
LEU A 138
SER A 131
 None
 0.99A 5m8rC-1yr0A:
undetectable		 5m8rC-1yr0A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1yr0 PHOSPHINOTHRICIN
ACETYLTRANSFERASE
(Agrobacterium
fabrum) 		4 / 8 HIS A  87
HIS A 135
LEU A 138
SER A 131
 None
 0.99A 5m8rD-1yr0A:
undetectable		 5m8rD-1yr0A:
17.30