SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 1yr1 CELL-DIVISION
INITIATION PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 7 PRO A 153
VAL A 154
THR A 168
LEU A 171
 None
 0.90A 1jgsA-1yr1A:
undetectable		 1jgsA-1yr1A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1yr1 CELL-DIVISION
INITIATION PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 PRO A 189
TRP A 158
ILE A 211
ARG A 212
 None
 0.97A 3sfeB-1yr1A:
undetectable
3sfeC-1yr1A:
undetectable		 3sfeB-1yr1A:
17.32
3sfeC-1yr1A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1yr1 CELL-DIVISION
INITIATION PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 5 ASN A 202
ALA A 181
TYR A 221
ALA A 223
 None
 1.38A 3twpD-1yr1A:
undetectable		 3twpD-1yr1A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 1yr1 CELL-DIVISION
INITIATION PROTEIN
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 195
ARG A 212
ASP A 162
 None
 0.90A 4fp9C-1yr1A:
undetectable		 4fp9C-1yr1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1yr1 CELL-DIVISION
INITIATION PROTEIN
(Geobacillus
stearothermophil
us) 		5 / 9 LEU A 171
THR A 168
LEU A 133
PRO A 153
LEU A 139
 None
 1.42A 5g48B-1yr1A:
undetectable		 5g48B-1yr1A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1yr1 CELL-DIVISION
INITIATION PROTEIN
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 169
LEU A 171
VAL A 124
LEU A 155
 None
 0.73A 6czmD-1yr1A:
undetectable
6czmF-1yr1A:
undetectable		 6czmD-1yr1A:
16.81
6czmF-1yr1A:
16.81