SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 VAL A 464
VAL A 474
TRP A 557
 None
 0.84A 1av2C-1yr2A:
undetectable
1av2D-1yr2A:
undetectable		 1av2C-1yr2A:
4.46
1av2D-1yr2A:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 ALA A 593
ALA A 649
PRO A 682
LEU A  92
TYR A  88
 GOL  A 750 ( 4.8A)
None
None
None
None
 1.21A 1cbrA-1yr2A:
undetectable		 1cbrA-1yr2A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 ALA A 593
ALA A 649
PRO A 682
LEU A  92
TYR A  88
 GOL  A 750 ( 4.8A)
None
None
None
None
 1.21A 1cbrB-1yr2A:
undetectable		 1cbrB-1yr2A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 7 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 1.06A 1dvxA-1yr2A:
undetectable		 1dvxA-1yr2A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ASP A 172
ASP A 220
ASP A 278
 None
 0.68A 1eizA-1yr2A:
2.6		 1eizA-1yr2A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ASP A 172
ASP A 220
ASP A 278
 None
 0.65A 1ej0A-1yr2A:
2.5		 1ej0A-1yr2A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 9 GLY A 539
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.02A 1hxwA-1yr2A:
undetectable		 1hxwA-1yr2A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.81A 1ictB-1yr2A:
undetectable		 1ictB-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ALA A  83
VAL A  78
TRP A  77
 None
 0.81A 1kqeA-1yr2A:
undetectable
1kqeE-1yr2A:
undetectable		 1kqeA-1yr2A:
3.08
1kqeE-1yr2A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ALA A  83
VAL A  78
TRP A  77
 None
 0.80A 1kqeB-1yr2A:
undetectable
1kqeD-1yr2A:
undetectable		 1kqeB-1yr2A:
3.08
1kqeD-1yr2A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 TRP A  77
ALA A  83
VAL A  78
 None
 0.81A 1kqeB-1yr2A:
undetectable
1kqeD-1yr2A:
undetectable		 1kqeB-1yr2A:
3.08
1kqeD-1yr2A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 TRP A  77
ALA A  83
VAL A  78
 None
 0.80A 1kqeA-1yr2A:
undetectable
1kqeE-1yr2A:
undetectable		 1kqeA-1yr2A:
3.08
1kqeE-1yr2A:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 ASP A 619
ASN A 576
GLY A 494
GLY A 529
GLU A 530
 None
 1.04A 1mehA-1yr2A:
undetectable		 1mehA-1yr2A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.02A 1muiB-1yr2A:
undetectable		 1muiB-1yr2A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 5 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.65A 1tt6B-1yr2A:
undetectable		 1tt6B-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 11 LEU A 684
ALA A 649
LEU A 651
SER A 596
LEU A 713
 None
 1.28A 1tz8A-1yr2A:
0.4
1tz8B-1yr2A:
0.5		 1tz8A-1yr2A:
11.34
1tz8B-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 11 LEU A 713
LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 1.29A 1tz8A-1yr2A:
0.4
1tz8B-1yr2A:
0.5		 1tz8A-1yr2A:
11.34
1tz8B-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.67A 1tz8C-1yr2A:
undetectable
1tz8D-1yr2A:
undetectable		 1tz8C-1yr2A:
11.34
1tz8D-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 VAL A 464
VAL A 474
TRP A 557
 None
 0.79A 1w5uC-1yr2A:
undetectable
1w5uD-1yr2A:
undetectable		 1w5uC-1yr2A:
4.46
1w5uD-1yr2A:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 4 LEU A 214
SER A 212
TYR A 224
LEU A 222
 None
 1.15A 1xz1A-1yr2A:
undetectable		 1xz1A-1yr2A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 10 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.05A 2aquA-1yr2A:
undetectable		 2aquA-1yr2A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 11 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.04A 2aquB-1yr2A:
undetectable		 2aquB-1yr2A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 532
PRO A 475
VAL A 474
 None
 1.48A 2avoB-1yr2A:
undetectable		 2avoB-1yr2A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.08A 2avvB-1yr2A:
undetectable		 2avvB-1yr2A:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
 None
 1.04A 2b7zA-1yr2A:
undetectable		 2b7zA-1yr2A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
VAL A 474
 None
 0.90A 2f8gA-1yr2A:
undetectable		 2f8gA-1yr2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		7 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 532
GLY A 529
PRO A 475
VAL A 474
 None
 1.08A 2fxeA-1yr2A:
undetectable		 2fxeA-1yr2A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 11 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.05A 2fxeB-1yr2A:
undetectable		 2fxeB-1yr2A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.02A 2ieoA-1yr2A:
undetectable		 2ieoA-1yr2A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 VAL A 474
TRP A 557
VAL A 464
 None
 0.82A 2izqA-1yr2A:
undetectable
2izqB-1yr2A:
undetectable		 2izqA-1yr2A:
4.46
2izqB-1yr2A:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 7 LEU A 492
LEU A 569
GLU A 462
ARG A 480
 None
 0.90A 2jn3A-1yr2A:
undetectable		 2jn3A-1yr2A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ARG A 101
VAL A 479
THR A 429
 None
 0.78A 2nmzA-1yr2A:
undetectable		 2nmzA-1yr2A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ARG A 101
VAL A 479
THR A 429
 None
 0.83A 2nnkA-1yr2A:
undetectable		 2nnkA-1yr2A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 11 GLY A 539
ALA A 538
ASP A 537
GLY A 532
PRO A 475
VAL A 474
 None
 1.48A 2nnpA-1yr2A:
undetectable		 2nnpA-1yr2A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 ALA A 538
ASP A 537
GLY A 532
GLY A 529
PRO A 475
 None
 1.05A 2o4kA-1yr2A:
undetectable		 2o4kA-1yr2A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.07A 2o4kB-1yr2A:
undetectable		 2o4kB-1yr2A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.10A 2q5kB-1yr2A:
undetectable		 2q5kB-1yr2A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.08A 2r5pB-1yr2A:
undetectable		 2r5pB-1yr2A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.08A 2r5pD-1yr2A:
undetectable		 2r5pD-1yr2A:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 4 ALA A  42
TYR A  40
ALA A  80
TYR A  84
 None
 1.20A 2wlkA-1yr2A:
undetectable
2wlkB-1yr2A:
undetectable		 2wlkA-1yr2A:
17.25
2wlkB-1yr2A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 5 ARG A 101
PHE A 510
LEU A 105
PHE A 454
 None
 1.34A 2y69C-1yr2A:
undetectable
2y69J-1yr2A:
undetectable		 2y69C-1yr2A:
16.55
2y69J-1yr2A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.07A 2z54A-1yr2A:
undetectable		 2z54A-1yr2A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
 None
 1.07A 2z54A-1yr2A:
undetectable		 2z54A-1yr2A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.08A 2z54B-1yr2A:
undetectable		 2z54B-1yr2A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 5 ARG A 101
PHE A 510
LEU A 105
PHE A 454
 None
 1.42A 3ablC-1yr2A:
undetectable
3ablJ-1yr2A:
undetectable		 3ablC-1yr2A:
16.55
3ablJ-1yr2A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 5 ARG A 101
PHE A 510
LEU A 105
PHE A 454
 None
 1.36A 3abmC-1yr2A:
0.8
3abmJ-1yr2A:
undetectable		 3abmC-1yr2A:
16.55
3abmJ-1yr2A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 5 ARG A 101
PHE A 510
LEU A 105
PHE A 454
 None
 1.35A 3abmP-1yr2A:
undetectable
3abmW-1yr2A:
undetectable		 3abmP-1yr2A:
16.55
3abmW-1yr2A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 4 ARG A 101
PHE A 510
LEU A 105
PHE A 454
 None
 1.41A 3ag1P-1yr2A:
0.8
3ag1W-1yr2A:
0.0		 3ag1P-1yr2A:
16.55
3ag1W-1yr2A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 4 ARG A 101
PHE A 510
LEU A 105
PHE A 454
 None
 1.36A 3ag3P-1yr2A:
0.8
3ag3W-1yr2A:
0.0		 3ag3P-1yr2A:
16.55
3ag3W-1yr2A:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 8 SER A 120
ARG A 117
VAL A 137
LEU A 151
ALA A 170
 None
 1.39A 3ax7A-1yr2A:
1.5		 3ax7A-1yr2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 9 SER A 120
ARG A 117
VAL A 137
LEU A 151
ALA A 170
 None
 1.42A 3ax7B-1yr2A:
undetectable		 3ax7B-1yr2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.79A 3cfqA-1yr2A:
undetectable		 3cfqA-1yr2A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 7 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.74A 3cfqA-1yr2A:
undetectable
3cfqB-1yr2A:
undetectable		 3cfqA-1yr2A:
11.92
3cfqB-1yr2A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
 None
 1.05A 3d1zB-1yr2A:
undetectable		 3d1zB-1yr2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 7 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.66A 3d2tA-1yr2A:
undetectable		 3d2tA-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 5 ALA A  97
LEU A 719
GLY A 517
THR A 429
 None
 0.85A 3dl9A-1yr2A:
undetectable		 3dl9A-1yr2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ASP A 172
ASP A 220
ASP A 278
 None
 0.75A 3douA-1yr2A:
2.6		 3douA-1yr2A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 11 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
 None
 1.09A 3ektD-1yr2A:
undetectable		 3ektD-1yr2A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 10 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.05A 3ekyA-1yr2A:
undetectable		 3ekyA-1yr2A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
 None
 1.00A 3el9B-1yr2A:
undetectable		 3el9B-1yr2A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 9 ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.11A 3em4B-1yr2A:
undetectable		 3em4B-1yr2A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 11 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.07A 3em4U-1yr2A:
undetectable		 3em4U-1yr2A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 ASP A 537
GLY A 532
GLY A 529
PRO A 475
VAL A 474
 None
 1.07A 3em4V-1yr2A:
undetectable		 3em4V-1yr2A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 8 GLY A 539
ALA A 538
ASP A 537
GLY A 532
VAL A 474
 None
 1.35A 3em6A-1yr2A:
undetectable		 3em6A-1yr2A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 ILE A 343
ILE A 313
LEU A 330
VAL A 369
ARG A 345
 None
 1.19A 3fpjB-1yr2A:
undetectable		 3fpjB-1yr2A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ARG A 686
THR A 717
THR A 512
 None
 0.72A 3k2hB-1yr2A:
undetectable		 3k2hB-1yr2A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ARG A 101
VAL A 479
THR A 429
 None
 0.87A 3k4vA-1yr2A:
undetectable		 3k4vA-1yr2A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 VAL A 464
VAL A 474
TRP A 557
 None
 0.77A 3l8lA-1yr2A:
undetectable
3l8lB-1yr2A:
undetectable		 3l8lA-1yr2A:
4.46
3l8lB-1yr2A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 VAL A 464
VAL A 474
TRP A 557
 None
 0.66A 3l8lC-1yr2A:
undetectable
3l8lD-1yr2A:
undetectable		 3l8lC-1yr2A:
4.46
3l8lD-1yr2A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.10A 3lzuB-1yr2A:
undetectable		 3lzuB-1yr2A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
 None
 1.06A 3mwsA-1yr2A:
undetectable		 3mwsA-1yr2A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
ARG A 540
 None
 1.01A 3n3iA-1yr2A:
undetectable		 3n3iA-1yr2A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 370
ASP A 321
GLY A 325
VAL A 326
VAL A 358
ILE A 343
 None
 1.03A 3nu5A-1yr2A:
undetectable		 3nu5A-1yr2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 ASP A 321
GLY A 325
VAL A 326
VAL A 358
ILE A 343
 None
 1.08A 3oxvB-1yr2A:
undetectable		 3oxvB-1yr2A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 GLY A 539
ALA A 538
ASP A 537
GLY A 529
VAL A 474
 None
 0.92A 3oxwA-1yr2A:
undetectable		 3oxwA-1yr2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 GLY A 539
ALA A 538
ASP A 537
GLY A 529
VAL A 474
 None
 0.93A 3oxwC-1yr2A:
undetectable		 3oxwC-1yr2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 11 ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.08A 3oxxB-1yr2A:
undetectable		 3oxxB-1yr2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
 None
 1.02A 3oxxC-1yr2A:
undetectable		 3oxxC-1yr2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 THR A 295
SER A 286
ARG A 269
 None
 0.75A 3phnA-1yr2A:
undetectable		 3phnA-1yr2A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ARG A 101
VAL A 479
THR A 429
 None
 0.84A 3pwrA-1yr2A:
undetectable		 3pwrA-1yr2A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 LEU A 713
PHE A 592
LEU A 569
GLY A 573
LEU A 580
 None
 1.03A 3tbgA-1yr2A:
undetectable		 3tbgA-1yr2A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 LEU A 713
PHE A 592
LEU A 569
GLY A 573
LEU A 580
 None
 1.05A 3tbgB-1yr2A:
undetectable		 3tbgB-1yr2A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 LEU A 713
PHE A 592
LEU A 569
GLY A 573
LEU A 580
 None
 1.02A 3tbgC-1yr2A:
undetectable		 3tbgC-1yr2A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 LEU A 713
PHE A 592
LEU A 569
GLY A 573
LEU A 580
 None
 1.05A 3tbgD-1yr2A:
undetectable		 3tbgD-1yr2A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 ARG A 101
VAL A 479
THR A 429
 None
 0.87A 3tl9A-1yr2A:
undetectable		 3tl9A-1yr2A:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 11 GLY A 539
ALA A 538
ASP A 537
GLY A 532
GLY A 529
PRO A 475
 None
 1.08A 3ufnA-1yr2A:
undetectable		 3ufnA-1yr2A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 LEU A 522
ILE A 406
GLY A 407
ASP A 383
ALA A 384
 None
 1.20A 3uj7B-1yr2A:
undetectable		 3uj7B-1yr2A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 TRP A  77
VAL A  46
TRP A  61
 None
 1.25A 3zq8C-1yr2A:
undetectable
3zq8D-1yr2A:
undetectable		 3zq8C-1yr2A:
4.46
3zq8D-1yr2A:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.67A 4d7bB-1yr2A:
undetectable		 4d7bB-1yr2A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 GLY A 539
ALA A 538
ASP A 537
GLY A 529
VAL A 474
 None
 0.89A 4dqbB-1yr2A:
undetectable		 4dqbB-1yr2A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 GLY A 539
ALA A 538
ASP A 537
GLY A 529
VAL A 474
 None
 0.89A 4dqeB-1yr2A:
undetectable		 4dqeB-1yr2A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 GLY A 539
ALA A 538
ASP A 537
GLY A 529
VAL A 474
 None
 0.91A 4dqhB-1yr2A:
undetectable		 4dqhB-1yr2A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 11 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.08A 4hlaB-1yr2A:
undetectable		 4hlaB-1yr2A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.63A 4i89A-1yr2A:
undetectable		 4i89A-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 8 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.81A 4ikkA-1yr2A:
undetectable
4ikkB-1yr2A:
undetectable		 4ikkA-1yr2A:
11.34
4ikkB-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
 None
 1.07A 4njvA-1yr2A:
undetectable		 4njvA-1yr2A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.66A 4pwjA-1yr2A:
undetectable		 4pwjA-1yr2A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 7 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.66A 4pwjB-1yr2A:
undetectable		 4pwjB-1yr2A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.69A 5bojA-1yr2A:
undetectable		 5bojA-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 7 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.71A 5bojB-1yr2A:
undetectable		 5bojB-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 195
GLY A 199
ASP A 198
LEU A 177
LEU A 202
 GOL  A 755 ( 3.8A)
None
GOL  A 755 ( 4.2A)
None
None
 1.19A 5bw4A-1yr2A:
undetectable		 5bw4A-1yr2A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6S_C_RAUC400_1
(IMINE REDUCTASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 TRP A 168
TYR A 123
GLY A 195
VAL A 121
LEU A 177
 None
None
GOL  A 755 ( 3.8A)
None
None
 1.45A 5g6sB-1yr2A:
undetectable
5g6sC-1yr2A:
undetectable		 5g6sB-1yr2A:
19.34
5g6sC-1yr2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 ASP A 590
ILE A 571
GLY A 555
LEU A 558
GLY A 582
 None
 1.10A 5i71A-1yr2A:
undetectable		 5i71A-1yr2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 ASP A 590
ILE A 571
PHE A 551
GLY A 555
LEU A 558
GLY A 582
 None
 1.39A 5i73A-1yr2A:
undetectable		 5i73A-1yr2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 ASP A 590
ILE A 571
GLY A 555
LEU A 558
GLY A 582
 None
 1.10A 5i75A-1yr2A:
undetectable		 5i75A-1yr2A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 ALA A 519
GLY A 517
LEU A 491
ALA A 521
ALA A 484
 None
 1.31A 5jglB-1yr2A:
undetectable		 5jglB-1yr2A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 ILE A 685
TYR A 669
TRP A  77
SER A  43
 None
 0.94A 5jwaH-1yr2A:
undetectable		 5jwaH-1yr2A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.72A 5l4iA-1yr2A:
undetectable		 5l4iA-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		4 / 6 LEU A 684
ALA A 649
LEU A 651
SER A 596
 None
 0.72A 5l4iB-1yr2A:
undetectable		 5l4iB-1yr2A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 8 VAL A  78
ILE A 687
ALA A 655
THR A 657
VAL A  68
 None
 1.27A 5l94A-1yr2A:
undetectable		 5l94A-1yr2A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
 None
 1.00A 5t2zA-1yr2A:
undetectable		 5t2zA-1yr2A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 TYR A 495
LEU A 580
GLY A 574
GLY A 600
GLY A 578
 None
 0.99A 5wyqB-1yr2A:
undetectable		 5wyqB-1yr2A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLU A 530
VAL A 584
PHE A 551
ILE A 552
PHE A 548
 None
 1.31A 6becA-1yr2A:
0.0
6becB-1yr2A:
undetectable
6becC-1yr2A:
undetectable		 6becA-1yr2A:
21.11
6becB-1yr2A:
21.11
6becC-1yr2A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 PHE A 498
GLY A 582
VAL A 584
GLY A 497
GLY A 527
 None
 1.19A 6brdB-1yr2A:
undetectable		 6brdB-1yr2A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 10 GLY A 417
ASP A 418
ARG A 116
SER A 413
ASP A 438
 None
 1.18A 6clxB-1yr2A:
1.4		 6clxB-1yr2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		5 / 12 GLY A 539
ALA A 538
GLY A 529
PRO A 475
VAL A 474
 None
 0.93A 6dh0B-1yr2A:
undetectable		 6dh0B-1yr2A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.09A 6dj1B-1yr2A:
undetectable		 6dj1B-1yr2A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		6 / 12 GLY A 539
ALA A 538
ASP A 537
GLY A 529
PRO A 475
VAL A 474
 None
 1.08A 6dj2B-1yr2A:
undetectable		 6dj2B-1yr2A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 1yr2 PROLYL
OLIGOPEPTIDASE
(Novosphingobium
capsulatum) 		3 / 3 LYS A  56
VAL A  49
ASP A  51
 None
 0.28A 6fgdA-1yr2A:
2.6		 6fgdA-1yr2A:
20.72