SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 6 TYR A  97
GLU A 239
TYR A  23
GLY A  21
 None
 1.12A 1maaB-1yr7A:
undetectable
1maaD-1yr7A:
undetectable		 1maaB-1yr7A:
19.56
1maaD-1yr7A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		5 / 11 GLY A 104
ILE A 130
SER A  11
ALA A 163
ILE A 152
 GSP  A 401 (-3.5A)
None
GSP  A 401 (-3.6A)
None
None
 1.15A 2nnhA-1yr7A:
0.0		 2nnhA-1yr7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		5 / 12 ILE A 100
THR A 102
LEU A 122
ASN A 121
VAL A  33
 None
 1.18A 2vn0A-1yr7A:
undetectable		 2vn0A-1yr7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		3 / 3 GLY A  68
GLY A  63
GLY A  65
 None
 0.34A 3bogC-1yr7A:
undetectable		 3bogC-1yr7A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 5 SER A  47
ARG A  22
GLY A  18
GLU A  19
 None
 1.20A 3k9fA-1yr7A:
undetectable
3k9fB-1yr7A:
undetectable
3k9fC-1yr7A:
undetectable		 3k9fA-1yr7A:
20.35
3k9fB-1yr7A:
20.35
3k9fC-1yr7A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		5 / 11 ILE A 100
MET A 119
ILE A 152
VAL A 127
VAL A   6
 None
 1.36A 3rf4A-1yr7A:
undetectable
3rf4B-1yr7A:
undetectable		 3rf4A-1yr7A:
18.68
3rf4B-1yr7A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		3 / 3 GLY A  10
GLY A  12
THR A  14
 GSP  A 401 (-3.7A)
GSP  A 401 (-2.9A)
GSP  A 401 (-2.6A)
 0.44A 3si7B-1yr7A:
undetectable		 3si7B-1yr7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 6 SER A  47
ARG A  22
GLY A  18
GLU A  19
 None
 1.06A 5btaA-1yr7A:
undetectable
5btaB-1yr7A:
undetectable
5btaC-1yr7A:
undetectable		 5btaA-1yr7A:
20.50
5btaB-1yr7A:
24.73
5btaC-1yr7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 6 SER A  47
ARG A  22
GLY A  18
GLU A  19
 None
 1.07A 5btcA-1yr7A:
undetectable
5btcC-1yr7A:
undetectable
5btcD-1yr7A:
undetectable		 5btcA-1yr7A:
20.50
5btcC-1yr7A:
20.50
5btcD-1yr7A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 6 SER A  47
ARG A  22
GLY A  18
GLU A  19
 None
 1.07A 5btcA-1yr7A:
undetectable
5btcB-1yr7A:
undetectable
5btcC-1yr7A:
undetectable		 5btcA-1yr7A:
20.50
5btcB-1yr7A:
24.73
5btcC-1yr7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 5 SER A  47
ARG A  22
GLY A  18
GLU A  19
 None
 0.94A 5btiA-1yr7A:
undetectable
5btiB-1yr7A:
undetectable		 5btiA-1yr7A:
20.50
5btiB-1yr7A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 5 SER A  47
ARG A  22
GLY A  18
GLU A  19
 None
 0.97A 5btiC-1yr7A:
undetectable
5btiD-1yr7A:
2.5		 5btiC-1yr7A:
20.50
5btiD-1yr7A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 5 SER A  47
ARG A  22
GLY A  18
GLU A  19
 None
 1.06A 5cdqA-1yr7A:
undetectable
5cdqB-1yr7A:
undetectable
5cdqC-1yr7A:
undetectable		 5cdqA-1yr7A:
20.37
5cdqB-1yr7A:
21.57
5cdqC-1yr7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 5 SER A  47
ARG A  22
GLY A  18
GLU A  19
 None
 1.07A 5cdqR-1yr7A:
undetectable
5cdqS-1yr7A:
1.8
5cdqT-1yr7A:
undetectable		 5cdqR-1yr7A:
20.37
5cdqS-1yr7A:
21.57
5cdqT-1yr7A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		3 / 3 ASP A  36
SER A  73
TYR A  74
 GSP  A 401 (-4.6A)
None
None
 0.79A 5glmA-1yr7A:
undetectable		 5glmA-1yr7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 8 LEU A 222
LEU A 236
THR A 160
TYR A 129
 None
 1.10A 5hbsA-1yr7A:
undetectable		 5hbsA-1yr7A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 4 ASP A 232
ILE A 161
PRO A 162
LEU A 220
 None
 1.30A 6mkeB-1yr7A:
undetectable		 6mkeB-1yr7A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1yr7 ATP(GTP)BINDING
PROTEIN
(Pyrococcus
abyssi) 		4 / 4 ASP A 232
ILE A 161
PRO A 162
LEU A 220
 None
 1.34A 6mkeA-1yr7A:
undetectable		 6mkeA-1yr7A:
15.77