SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yrg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 5 LEU A 246
LEU A 249
SER A 233
LEU A 256
 None
 1.05A 1a4lC-1yrgA:
undetectable		 1a4lC-1yrgA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 8 ALA A  65
LEU A  96
LEU A 124
LEU A  86
 None
 0.91A 1ereE-1yrgA:
undetectable		 1ereE-1yrgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 8 ALA A  65
LEU A  96
LEU A 124
LEU A  86
 None
 0.91A 1ereF-1yrgA:
undetectable		 1ereF-1yrgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 212
LEU A 236
LEU A 223
HIS A 206
LEU A 209
 None
 1.23A 1g50B-1yrgA:
undetectable		 1g50B-1yrgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 212
LEU A 236
LEU A 223
HIS A 206
LEU A 209
 None
 1.23A 1g50C-1yrgA:
undetectable		 1g50C-1yrgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 251
LEU A 281
LEU A 310
LEU A 276
MET A 302
 None
 1.44A 1sqnA-1yrgA:
undetectable		 1sqnA-1yrgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 276
PHE A 228
LEU A 207
SER A 242
 None
 1.01A 1wrlC-1yrgA:
undetectable
1wrlD-1yrgA:
undetectable		 1wrlC-1yrgA:
12.87
1wrlD-1yrgA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU A 114
LEU A 129
PHE A  71
SER A  40
 None
 1.01A 1wrlE-1yrgA:
undetectable
1wrlF-1yrgA:
undetectable		 1wrlE-1yrgA:
12.87
1wrlF-1yrgA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 129
SER A 102
TYR A 128
LEU A 127
 None
 1.25A 1xz1A-1yrgA:
undetectable		 1xz1A-1yrgA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 129
SER A 102
TYR A 128
LEU A 127
 None
 1.26A 1xz3A-1yrgA:
undetectable		 1xz3A-1yrgA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE A   6
SER A  68
LEU A  39
ASN A  42
 None
 1.04A 1y0xX-1yrgA:
undetectable		 1y0xX-1yrgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 7 PHE A  25
LEU A  28
ASN A  42
ILE A  44
 None
 0.84A 1yc2E-1yrgA:
undetectable		 1yc2E-1yrgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A 118
LEU A  91
LEU A  87
LEU A  96
 None
 0.94A 2ab2A-1yrgA:
undetectable		 2ab2A-1yrgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  39
PHE A  67
LEU A  52
LEU A  29
VAL A  34
 None
 1.22A 2hrcA-1yrgA:
undetectable		 2hrcA-1yrgA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  39
PHE A  67
LEU A  52
LEU A  29
VAL A  34
 None
 1.25A 2hrcB-1yrgA:
undetectable		 2hrcB-1yrgA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A  39
PHE A  67
LEU A  52
LEU A  29
VAL A  34
 None
 1.28A 2qd4B-1yrgA:
undetectable		 2qd4B-1yrgA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 161
ILE A 164
LEU A 127
LEU A 149
 None
 0.68A 2xfhA-1yrgA:
undetectable		 2xfhA-1yrgA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP A 323
LEU A 337
ASP A 319
LEU A 288
 None
 1.24A 3bj8C-1yrgA:
undetectable
3bj8D-1yrgA:
undetectable		 3bj8C-1yrgA:
17.90
3bj8D-1yrgA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 251
LEU A 281
LEU A 310
LEU A 276
MET A 302
 None
 1.43A 3d90A-1yrgA:
undetectable		 3d90A-1yrgA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 8 TYR A 128
ASP A 222
GLN A 224
GLU A 309
 None
 1.43A 3dh0A-1yrgA:
undetectable		 3dh0A-1yrgA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 10 SER A 257
LEU A 223
ILE A 204
PRO A 201
GLY A 232
 None
 1.39A 3ijxB-1yrgA:
undetectable
3ijxD-1yrgA:
undetectable		 3ijxB-1yrgA:
21.26
3ijxD-1yrgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE A 204
PRO A 201
GLY A 232
SER A 257
LEU A 223
 None
 1.30A 3ik6B-1yrgA:
undetectable
3ik6E-1yrgA:
undetectable		 3ik6B-1yrgA:
21.26
3ik6E-1yrgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 10 SER A 257
LEU A 223
ILE A 204
PRO A 201
GLY A 232
 None
 1.31A 3iluB-1yrgA:
undetectable
3iluE-1yrgA:
undetectable		 3iluB-1yrgA:
21.26
3iluE-1yrgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 11 ILE A 204
PRO A 201
GLY A 232
SER A 257
LEU A 223
 None
 1.35A 3iluB-1yrgA:
undetectable
3iluE-1yrgA:
undetectable		 3iluB-1yrgA:
21.26
3iluE-1yrgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 8 ALA A 262
VAL A 265
ASP A 266
THR A 293
 None
 0.73A 3roxA-1yrgA:
undetectable		 3roxA-1yrgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 GLN A 111
ALA A 138
ASN A 169
ALA A 105
ALA A 110
 None
 1.13A 3ut5D-1yrgA:
undetectable		 3ut5D-1yrgA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 208
LEU A 212
LEU A 218
ILE A 204
 None
 0.74A 4klaA-1yrgA:
undetectable		 4klaA-1yrgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 246
SER A 242
LEU A 271
LEU A 249
 None
 1.03A 4n09A-1yrgA:
2.2		 4n09A-1yrgA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 146
LEU A 149
VAL A  99
LEU A  96
LEU A  90
 None
 1.04A 4po0A-1yrgA:
undetectable		 4po0A-1yrgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 10 ALA A  89
ILE A  56
CYH A  93
LEU A  96
ALA A  65
 None
 1.05A 5ajqB-1yrgA:
undetectable		 5ajqB-1yrgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		3 / 3 LEU A 129
LEU A 118
ARG A 162
 None
 0.56A 5hnzB-1yrgA:
undetectable		 5hnzB-1yrgA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 VAL A 321
ILE A 286
LEU A 294
LEU A 308
PHE A 315
 None
 1.24A 5im2A-1yrgA:
undetectable		 5im2A-1yrgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 106
ILE A  44
ALA A  82
LEU A  83
ALA A 110
 None
 1.09A 5oy02-1yrgA:
undetectable		 5oy02-1yrgA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		5 / 12 HIS A 186
LEU A 127
ILE A 142
ALA A 143
GLU A 178
 None
 1.03A 5v0vA-1yrgA:
undetectable		 5v0vA-1yrgA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 6 GLU A 178
HIS A 206
ALA A 180
GLN A 184
 None
 1.50A 6f6jC-1yrgA:
undetectable
6f6jD-1yrgA:
undetectable		 6f6jC-1yrgA:
22.17
6f6jD-1yrgA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 253
HIS A 130
ASP A 222
GLU A 248
 None
 1.20A 6mn4B-1yrgA:
undetectable		 6mn4B-1yrgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1yrg GTPASE-ACTIVATING
PROTEIN RNA1_SCHPO
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 253
HIS A 130
ASP A 222
GLU A 248
 None
 1.16A 6mn4D-1yrgA:
undetectable		 6mn4D-1yrgA:
22.86