SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yrv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130
(Homo
sapiens) 		4 / 8 SER A  46
VAL A  47
LEU A 144
PRO A 119
 None
 0.95A 1fduB-1yrvA:
undetectable		 1fduB-1yrvA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130
(Homo
sapiens) 		4 / 8 PHE A 147
ALA A 129
ILE A 132
ASN A 126
 None
 1.03A 1pnlA-1yrvA:
undetectable
1pnlB-1yrvA:
undetectable		 1pnlA-1yrvA:
21.86
1pnlB-1yrvA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130
(Homo
sapiens) 		4 / 5 ILE A  75
PRO A  76
PHE A 147
PHE A  77
 None
 0.88A 2hjhA-1yrvA:
undetectable		 2hjhA-1yrvA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130
(Homo
sapiens) 		4 / 6 ILE A  40
PRO A  68
LEU A 105
ILE A 108
 None
 0.95A 2q83B-1yrvA:
undetectable		 2q83B-1yrvA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130
(Homo
sapiens) 		5 / 12 LEU A 109
ARG A  11
LEU A  93
PRO A  68
VAL A  70
 None
 1.30A 2qd4A-1yrvA:
undetectable		 2qd4A-1yrvA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130
(Homo
sapiens) 		5 / 12 LEU A 109
ARG A  11
LEU A  93
PRO A  68
VAL A  70
 None
 1.30A 2qd4B-1yrvA:
undetectable		 2qd4B-1yrvA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130
(Homo
sapiens) 		4 / 8 ARG A  11
PRO A  28
MET A  34
TRP A  36
 None
 1.19A 4f4dB-1yrvA:
undetectable		 4f4dB-1yrvA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130
(Homo
sapiens) 		4 / 5 LEU A  93
ALA A 111
VAL A  38
ILE A  40
 None
 0.89A 4xe3A-1yrvA:
undetectable		 4xe3A-1yrvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130
(Homo
sapiens) 		4 / 5 LEU A  93
ALA A 111
VAL A  38
ILE A  40
 None
 0.73A 4xe3B-1yrvA:
undetectable		 4xe3B-1yrvA:
17.69