SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yrw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 12 LEU A  74
ILE A  54
ALA A  28
PRO A  59
LEU A  66
 None
 1.08A 1cbsA-1yrwA:
undetectable		 1cbsA-1yrwA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 12 GLY A 279
SER A 290
ALA A 293
LEU A 296
ASP A 226
 None
 1.20A 1i9gA-1yrwA:
4.1		 1i9gA-1yrwA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		3 / 3 TRP A 210
TYR A 234
LEU A 296
 None
 1.10A 1kxhA-1yrwA:
undetectable		 1kxhA-1yrwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 6 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.18A 1uwhB-1yrwA:
undetectable		 1uwhB-1yrwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 12 LEU A  74
ILE A  54
ALA A  28
PRO A  59
LEU A  66
 None
 1.08A 2fr3A-1yrwA:
undetectable		 2fr3A-1yrwA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.35A 2ocfA-1yrwA:
undetectable		 2ocfA-1yrwA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 8 ALA A 281
LEU A 296
LEU A 298
ILE A 276
VAL A 259
 None
 1.45A 2uxpA-1yrwA:
undetectable		 2uxpA-1yrwA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		6 / 11 ILE A  88
ALA A 100
LEU A  95
ILE A  92
SER A  27
PHE A   6
 None
 1.39A 2w9sA-1yrwA:
undetectable		 2w9sA-1yrwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		6 / 11 ILE A  88
ALA A 100
LEU A  95
ILE A  92
SER A  27
PHE A   6
 None
 1.39A 2w9sB-1yrwA:
undetectable		 2w9sB-1yrwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		4 / 4 ARG A 138
GLY A 142
GLU A 192
SER A  81
 None
 0.84A 2xctS-1yrwA:
undetectable
2xctU-1yrwA:
undetectable		 2xctS-1yrwA:
17.43
2xctU-1yrwA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 11 LEU A 177
ALA A  18
LEU A  20
VAL A   5
LYS A   1
 None
 1.14A 3e22B-1yrwA:
3.5		 3e22B-1yrwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 11 LEU A 177
ALA A  18
LEU A  20
VAL A   5
LYS A   1
 None
 1.14A 3e22D-1yrwA:
4.7		 3e22D-1yrwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 12 TYR A 111
GLY A 113
GLY A 105
SER A 106
LEU A 165
 None
 1.17A 3e23A-1yrwA:
3.9		 3e23A-1yrwA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 12 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.20A 3erdA-1yrwA:
undetectable		 3erdA-1yrwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 11 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.26A 3uudA-1yrwA:
undetectable		 3uudA-1yrwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 12 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.08A 3vywA-1yrwA:
2.8		 3vywA-1yrwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 12 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.07A 3vywB-1yrwA:
2.7		 3vywB-1yrwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 12 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.06A 3vywC-1yrwA:
3.8		 3vywC-1yrwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 12 TYR A  24
GLY A  15
ALA A 169
PHE A  80
LEU A 103
 None
 1.06A 3vywD-1yrwA:
undetectable		 3vywD-1yrwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		3 / 3 GLU A 275
ARG A 246
HIS A 248
 None
 0.84A 4kf9A-1yrwA:
undetectable		 4kf9A-1yrwA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 11 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.25A 4zn7B-1yrwA:
undetectable		 4zn7B-1yrwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 8 ILE A 144
VAL A 145
VAL A   4
ILE A  88
ILE A  71
 None
 1.24A 5hi2A-1yrwA:
undetectable		 5hi2A-1yrwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 10 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.22A 5hyrA-1yrwA:
undetectable		 5hyrA-1yrwA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		5 / 11 LEU A 266
ILE A 276
ILE A 260
SER A 245
LEU A 274
 None
 0.95A 5twjD-1yrwA:
undetectable		 5twjD-1yrwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		4 / 5 LEU A 165
ALA A 169
LEU A 172
LEU A  14
 None
 0.82A 5vkqA-1yrwA:
undetectable
5vkqD-1yrwA:
undetectable		 5vkqA-1yrwA:
11.52
5vkqD-1yrwA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		4 / 5 LEU A  14
LEU A 165
ALA A 169
LEU A 172
 None
 0.81A 5vkqA-1yrwA:
undetectable
5vkqB-1yrwA:
undetectable		 5vkqA-1yrwA:
11.52
5vkqB-1yrwA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		4 / 5 LEU A  14
LEU A 165
ALA A 169
LEU A 172
 None
 0.76A 5vkqB-1yrwA:
undetectable
5vkqC-1yrwA:
undetectable		 5vkqB-1yrwA:
11.52
5vkqC-1yrwA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1yrw PROTEIN ARNA
(Escherichia
coli) 		4 / 5 LEU A  14
LEU A 165
ALA A 169
LEU A 172
 None
 0.85A 5vkqC-1yrwA:
undetectable
5vkqD-1yrwA:
undetectable		 5vkqC-1yrwA:
11.52
5vkqD-1yrwA:
11.52