SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yrz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		3 / 3 ARG A1496
GLY A1433
ASP A1410
 None
 0.56A 1kf6A-1yrzA:
undetectable
1kf6B-1yrzA:
undetectable		 1kf6A-1yrzA:
22.64
1kf6B-1yrzA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 6 ARG A1280
ILE A1074
TRP A1075
GLU A1034
 None
 1.47A 1nsiA-1yrzA:
undetectable
1nsiB-1yrzA:
undetectable		 1nsiA-1yrzA:
21.34
1nsiB-1yrzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 6 GLU A1034
ARG A1280
ILE A1074
TRP A1075
 None
 1.44A 1nsiA-1yrzA:
undetectable
1nsiB-1yrzA:
undetectable		 1nsiA-1yrzA:
21.34
1nsiB-1yrzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		6 / 12 ILE A1284
GLN A1285
THR A1282
GLY A1251
GLY A1249
LEU A1253
 None
 1.19A 1rjdA-1yrzA:
undetectable		 1rjdA-1yrzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		6 / 12 ILE A1284
GLN A1285
THR A1282
GLY A1251
GLY A1249
LEU A1253
 None
 1.17A 1rjdB-1yrzA:
undetectable		 1rjdB-1yrzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 12 ILE A1284
GLN A1285
GLY A1251
GLY A1249
LEU A1253
 None
 1.02A 1rjdC-1yrzA:
undetectable		 1rjdC-1yrzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 7 PHE A1521
LEU A1402
GLU A1323
ARG A1522
 None
 1.02A 2jn3A-1yrzA:
undetectable		 2jn3A-1yrzA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 12 ALA A1264
THR A1282
ILE A1005
LEU A1313
TYR A1026
 None
 1.19A 2nyrA-1yrzA:
undetectable		 2nyrA-1yrzA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 12 LEU A1202
LEU A1216
GLY A1251
HIS A1265
LEU A1263
 None
 1.02A 2ouzA-1yrzA:
undetectable		 2ouzA-1yrzA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		3 / 3 SER A1370
THR A1338
PHE A1518
 None
 0.71A 2x91A-1yrzA:
undetectable		 2x91A-1yrzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		3 / 3 ARG A1358
GLU A1352
SER A1510
 None
 0.91A 2xctD-1yrzA:
undetectable		 2xctD-1yrzA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		3 / 3 GLU A1163
ASP A1135
TYR A1199
 None
 0.84A 2yvlB-1yrzA:
undetectable		 2yvlB-1yrzA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 12 ILE A1284
GLN A1285
GLY A1251
GLY A1249
LEU A1253
 None
 1.19A 2zw9A-1yrzA:
6.6		 2zw9A-1yrzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 7 ILE A1428
LEU A1414
MET A1463
THR A1462
 None
 1.16A 2zxwN-1yrzA:
undetectable
2zxwW-1yrzA:
undetectable		 2zxwN-1yrzA:
20.25
2zxwW-1yrzA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 8 GLU A1281
TYR A1523
ARG A1269
PHE A1381
 None
 1.07A 3mjrD-1yrzA:
undetectable		 3mjrD-1yrzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 6 ILE A1428
LEU A1414
MET A1463
THR A1462
 None
 1.18A 3wg7A-1yrzA:
undetectable
3wg7J-1yrzA:
undetectable		 3wg7A-1yrzA:
20.25
3wg7J-1yrzA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 7 GLU A1034
ARG A1280
ILE A1074
TRP A1075
 None
 1.44A 4cx7C-1yrzA:
undetectable
4cx7D-1yrzA:
undetectable		 4cx7C-1yrzA:
21.34
4cx7D-1yrzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		3 / 3 ARG A1051
TYR A1523
ASN A1337
 None
 0.94A 4ffwB-1yrzA:
6.1		 4ffwB-1yrzA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 9 ALA A1400
LEU A1359
PHE A1518
THR A1387
LEU A1454
 None
 1.39A 4ltwA-1yrzA:
undetectable		 4ltwA-1yrzA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 7 GLU A1034
ARG A1280
ILE A1074
TRP A1075
 None
 1.44A 4nosA-1yrzA:
undetectable
4nosB-1yrzA:
undetectable		 4nosA-1yrzA:
21.76
4nosB-1yrzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 7 ARG A1280
ILE A1074
TRP A1075
GLU A1034
 None
 1.42A 4nosC-1yrzA:
undetectable
4nosD-1yrzA:
undetectable		 4nosC-1yrzA:
21.76
4nosD-1yrzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 6 GLU A1034
ARG A1280
ILE A1074
TRP A1075
 None
 1.46A 4nosC-1yrzA:
undetectable
4nosD-1yrzA:
undetectable		 4nosC-1yrzA:
21.76
4nosD-1yrzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 12 LEU A1088
THR A1032
ILE A1074
GLN A1062
LEU A1063
 None
 1.19A 5b8hA-1yrzA:
undetectable
5b8hB-1yrzA:
undetectable		 5b8hA-1yrzA:
21.32
5b8hB-1yrzA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 12 GLN A1062
LEU A1063
LEU A1088
THR A1032
ILE A1074
 None
 1.19A 5b8hA-1yrzA:
undetectable
5b8hB-1yrzA:
undetectable		 5b8hA-1yrzA:
21.32
5b8hB-1yrzA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 10 TYR A1026
ASP A1046
ALA A1264
ILE A1284
SER A1044
 None
 1.26A 5i6xA-1yrzA:
undetectable		 5i6xA-1yrzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 8 THR A1366
THR A1408
ALA A1505
TRP A1035
 None
 1.00A 5x2tI-1yrzA:
undetectable
5x2tJ-1yrzA:
undetectable
5x2tK-1yrzA:
undetectable
5x2tL-1yrzA:
undetectable		 5x2tI-1yrzA:
17.23
5x2tJ-1yrzA:
14.23
5x2tK-1yrzA:
17.23
5x2tL-1yrzA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 9 TYR A1026
ASP A1046
ALA A1264
ILE A1284
SER A1044
 None
 1.25A 6awoA-1yrzA:
undetectable		 6awoA-1yrzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 9 TYR A1026
ASP A1046
ALA A1264
ILE A1284
SER A1044
 None
 1.26A 6awqA-1yrzA:
undetectable		 6awqA-1yrzA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 6 GLY A1433
ASP A1410
SER A1491
ARG A1496
 None
 1.18A 6dwdA-1yrzA:
undetectable
6dwdC-1yrzA:
undetectable		 6dwdA-1yrzA:
21.79
6dwdC-1yrzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 8 GLN A1285
ASN A1007
PRO A1008
ILE A1009
 None
 1.06A 6hzpA-1yrzA:
undetectable		 6hzpA-1yrzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		5 / 11 ILE A1297
ALA A1214
LEU A1253
GLY A1251
ALA A1283
 None
 1.33A 6ieyA-1yrzA:
undetectable
6ieyB-1yrzA:
undetectable		 6ieyA-1yrzA:
19.44
6ieyB-1yrzA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yrz XYLAN
BETA-1,4-XYLOSIDASE
(Bacillus
halodurans) 		4 / 6 ILE A1428
LEU A1414
MET A1463
THR A1462
 None
 1.05A 6nmfN-1yrzA:
undetectable
6nmfW-1yrzA:
undetectable		 6nmfN-1yrzA:
20.25
6nmfW-1yrzA:
7.98