SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ys4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  36
VAL A  11
MET A  33
ALA A 346
PHE A  88
 None
 1.02A 1gseA-1ys4A:
undetectable		 1gseA-1ys4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  36
VAL A  11
MET A  33
ALA A 346
PHE A  88
 None
 0.97A 1gseB-1ys4A:
undetectable		 1gseB-1ys4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 9 VAL A 178
ALA A 162
THR A 182
ILE A 254
SER A 158
 None
 1.33A 1gtnL-1ys4A:
0.2
1gtnM-1ys4A:
undetectable		 1gtnL-1ys4A:
12.50
1gtnM-1ys4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 10 SER A 112
SER A  89
ASN A 113
GLY A  21
GLY A  12
 None
None
NAP  A 900 (-3.3A)
None
None
 1.32A 1mehA-1ys4A:
undetectable		 1mehA-1ys4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ALA A 338
GLY A 249
HIS A 332
GLY A 188
VAL A 246
 NAP  A 900 (-3.6A)
None
None
NAP  A 900 (-2.8A)
None
 1.13A 1pg2A-1ys4A:
undetectable		 1pg2A-1ys4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ALA A 104
TYR A 117
ILE A 110
PHE A  99
 None
None
None
NAP  A 900 ( 4.9A)
 0.90A 1upfB-1ys4A:
2.2		 1upfB-1ys4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 150
ILE A 151
GLN A 141
ILE A 138
MET A 119
 None
 0.86A 1xozA-1ys4A:
undetectable		 1xozA-1ys4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A  93
ASP A  94
PRO A  92
SER A 115
 None
None
NAP  A 900 (-4.3A)
MLA  A 904 (-4.1A)
 1.42A 2hdnA-1ys4A:
undetectable
2hdnB-1ys4A:
undetectable
2hdnD-1ys4A:
1.9		 2hdnA-1ys4A:
7.06
2hdnB-1ys4A:
22.28
2hdnD-1ys4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 SER A 115
SER A  93
ASP A  94
PRO A  92
 MLA  A 904 (-4.1A)
None
None
NAP  A 900 (-4.3A)
 1.43A 2hdnB-1ys4A:
undetectable
2hdnC-1ys4A:
undetectable
2hdnD-1ys4A:
1.9		 2hdnB-1ys4A:
22.28
2hdnC-1ys4A:
7.06
2hdnD-1ys4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 221
LEU A 222
LEU A 175
ILE A 127
VAL A 325
 None
 1.13A 2pnjA-1ys4A:
3.6		 2pnjA-1ys4A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A  38
PHE A 111
ILE A  86
ASP A  85
PHE A  88
 None
 1.33A 2v95A-1ys4A:
undetectable		 2v95A-1ys4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 350
ILE A  86
ASP A  85
PHE A  34
LYS A   8
 None
 1.11A 2v95A-1ys4A:
undetectable		 2v95A-1ys4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.23A 2zweA-1ys4A:
undetectable
2zweB-1ys4A:
undetectable		 2zweA-1ys4A:
21.47
2zweB-1ys4A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.24A 2zwfA-1ys4A:
undetectable
2zwfB-1ys4A:
undetectable		 2zwfA-1ys4A:
21.47
2zwfB-1ys4A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.29A 2zwgA-1ys4A:
undetectable
2zwgB-1ys4A:
0.0		 2zwgA-1ys4A:
21.47
2zwgB-1ys4A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		6 / 12 ALA A  38
GLY A  15
SER A  89
GLY A  12
LEU A  95
ALA A  41
 None
NAP  A 900 (-3.2A)
None
None
NAP  A 900 (-4.6A)
NAP  A 900 (-3.4A)
 1.28A 3douA-1ys4A:
4.2		 3douA-1ys4A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLU A 347
HIS A  31
THR A 284
 None
 0.82A 3hkuA-1ys4A:
undetectable		 3hkuA-1ys4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 THR A 284
LEU A  27
VAL A  11
GLY A  12
ILE A 110
 None
 0.98A 3ijdA-1ys4A:
undetectable		 3ijdA-1ys4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 221
VAL A 163
VAL A 126
PHE A 274
 None
 1.09A 3soaA-1ys4A:
undetectable		 3soaA-1ys4A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 PHE A  81
GLY A  15
ILE A  72
VAL A  71
 None
NAP  A 900 (-3.2A)
None
None
 0.79A 3wrkA-1ys4A:
undetectable		 3wrkA-1ys4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 SER A 112
SER A  89
GLY A  21
GLY A  12
 None
 0.88A 4fo4B-1ys4A:
undetectable		 4fo4B-1ys4A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A 125
ASN A 345
LEU A 135
GLU A 136
 None
 1.13A 4nc3A-1ys4A:
undetectable		 4nc3A-1ys4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 222
LEU A 221
VAL A 130
ILE A 164
 None
 0.96A 4oj4A-1ys4A:
undetectable		 4oj4A-1ys4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		4 / 5 PHE A 274
ARG A 336
ILE A 127
ILE A 164
 None
 1.05A 5dzk4-1ys4A:
undetectable
5dzkg-1ys4A:
undetectable
5dzkm-1ys4A:
undetectable
5dzkn-1ys4A:
undetectable		 5dzk4-1ys4A:
7.14
5dzkg-1ys4A:
20.83
5dzkm-1ys4A:
22.69
5dzkn-1ys4A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 GLU A 120
VAL A 123
ASP A 122
LEU A  14
GLY A 149
 None
 1.18A 5syeB-1ys4A:
3.9		 5syeB-1ys4A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  13
ALA A  41
TYR A  50
ALA A  16
GLY A  15
 None
NAP  A 900 (-3.4A)
None
None
NAP  A 900 (-3.2A)
 1.30A 5tzoA-1ys4A:
undetectable		 5tzoA-1ys4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  13
ALA A  41
TYR A  50
ALA A  16
GLY A  15
 None
NAP  A 900 (-3.4A)
None
None
NAP  A 900 (-3.2A)
 1.30A 5tzoC-1ys4A:
undetectable		 5tzoC-1ys4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 341
GLY A 309
PHE A  24
GLY A  21
ALA A  90
 None
 0.95A 5w4zA-1ys4A:
0.5		 5w4zA-1ys4A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.33A 5z0fA-1ys4A:
undetectable
5z0fB-1ys4A:
undetectable		 5z0fA-1ys4A:
11.85
5z0fB-1ys4A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.33A 5z0gA-1ys4A:
undetectable
5z0gB-1ys4A:
undetectable		 5z0gA-1ys4A:
11.85
5z0gB-1ys4A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.24A 5z0hA-1ys4A:
undetectable
5z0hB-1ys4A:
undetectable		 5z0hA-1ys4A:
11.85
5z0hB-1ys4A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.25A 5z0iA-1ys4A:
undetectable
5z0iB-1ys4A:
undetectable		 5z0iA-1ys4A:
11.85
5z0iB-1ys4A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.23A 5z0jA-1ys4A:
undetectable
5z0jB-1ys4A:
undetectable		 5z0jA-1ys4A:
11.85
5z0jB-1ys4A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.27A 5z0kA-1ys4A:
undetectable
5z0kB-1ys4A:
0.0		 5z0kA-1ys4A:
11.85
5z0kB-1ys4A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.26A 5z0lA-1ys4A:
undetectable
5z0lB-1ys4A:
undetectable		 5z0lA-1ys4A:
11.85
5z0lB-1ys4A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 1ys4 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 335
VAL A 313
HIS A 332
ASP A 303
PRO A 300
 None
 1.16A 5z0mA-1ys4A:
undetectable
5z0mB-1ys4A:
undetectable		 5z0mA-1ys4A:
11.85
5z0mB-1ys4A:
13.28