SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ys7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		5 / 10 GLY A  66
ASP A  65
LEU A  64
ASP A  39
ALA A 102
 None
 1.48A 1fpqA-1ys7A:
undetectable		 1fpqA-1ys7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		3 / 3 THR A  71
GLU A  99
ASP A  93
 None
 0.84A 1nt2A-1ys7A:
undetectable		 1nt2A-1ys7A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 160
PHE A 165
THR A 138
LEU A 142
 None
 0.92A 1v55N-1ys7A:
undetectable
1v55W-1ys7A:
undetectable		 1v55N-1ys7A:
18.22
1v55W-1ys7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		4 / 7 SER A  68
ASP A  65
SER A  86
LEU A  57
 None
 0.91A 2cdqB-1ys7A:
1.9		 2cdqB-1ys7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 151
LEU A 211
LEU A 230
ILE A 204
LEU A 184
 None
 1.11A 2oipD-1ys7A:
undetectable		 2oipD-1ys7A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  85
LEU A 122
PHE A 110
 None
 0.71A 2pgrA-1ys7A:
undetectable		 2pgrA-1ys7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 160
PHE A 165
THR A 138
LEU A 142
 None
 0.91A 3abkA-1ys7A:
undetectable
3abkJ-1ys7A:
undetectable		 3abkA-1ys7A:
18.22
3abkJ-1ys7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 142
ARG A 149
LEU A 160
ALA A 169
 None
 1.18A 3b9mA-1ys7A:
undetectable		 3b9mA-1ys7A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  47
GLY A  40
LEU A  64
VAL A  82
ILE A  55
 None
 1.19A 3em4B-1ys7A:
undetectable		 3em4B-1ys7A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 151
LEU A 211
LEU A 230
ILE A 204
LEU A 184
 None
 1.21A 3hj3A-1ys7A:
undetectable		 3hj3A-1ys7A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  58
VAL A  19
PHE A 110
LEU A 115
 MG  A1002 (-2.7A)
None
None
None
 0.98A 4f8hA-1ys7A:
undetectable
4f8hB-1ys7A:
undetectable		 4f8hA-1ys7A:
26.11
4f8hB-1ys7A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  58
VAL A  19
PHE A 110
LEU A 115
 MG  A1002 (-2.7A)
None
None
None
 0.96A 4f8hB-1ys7A:
undetectable
4f8hC-1ys7A:
undetectable		 4f8hB-1ys7A:
26.11
4f8hC-1ys7A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  58
VAL A  19
PHE A 110
LEU A 115
 MG  A1002 (-2.7A)
None
None
None
 0.98A 4f8hC-1ys7A:
undetectable
4f8hD-1ys7A:
undetectable		 4f8hC-1ys7A:
26.11
4f8hD-1ys7A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		4 / 8 ASP A  58
VAL A  19
PHE A 110
LEU A 115
 MG  A1002 (-2.7A)
None
None
None
 0.98A 4f8hD-1ys7A:
undetectable
4f8hE-1ys7A:
undetectable		 4f8hD-1ys7A:
26.11
4f8hE-1ys7A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  19
PHE A 110
LEU A 115
ASP A  58
 None
None
None
MG  A1002 (-2.7A)
 0.97A 4f8hA-1ys7A:
undetectable
4f8hE-1ys7A:
undetectable		 4f8hA-1ys7A:
26.11
4f8hE-1ys7A:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 144
VAL A 158
PHE A 165
LEU A 167
LEU A 168
 None
 1.06A 4i1rA-1ys7A:
4.7		 4i1rA-1ys7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 1ys7 TRANSCRIPTIONAL
REGULATORY PROTEIN
PRRA
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  53
ARG A 163
ARG A  74
 None
 0.96A 5eajB-1ys7A:
undetectable		 5eajB-1ys7A:
20.85