SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ys9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.15A 1dz4B-1ys9A:
undetectable		 1dz4B-1ys9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 5 TYR A  15
VAL A  52
VAL A  41
ASP A   9
 None
 1.44A 1dz6B-1ys9A:
undetectable		 1dz6B-1ys9A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 ASP A 206
ASN A 207
ASP A   9
TYR A  15
 None
 1.16A 1hpkA-1ys9A:
undetectable		 1hpkA-1ys9A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 8 GLU A  94
ALA A 161
ALA A  72
THR A  76
 None
 0.88A 1ie4B-1ys9A:
undetectable
1ie4D-1ys9A:
undetectable		 1ie4B-1ys9A:
19.92
1ie4D-1ys9A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 5 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.12A 1t88B-1ys9A:
undetectable		 1t88B-1ys9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.08A 2feuA-1ys9A:
0.0		 2feuA-1ys9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		5 / 9 LEU A 191
GLY A 215
ALA A 214
GLY A 205
ILE A 223
 None
 1.06A 3ektA-1ys9A:
undetectable		 3ektA-1ys9A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.08A 3fwgA-1ys9A:
undetectable		 3fwgA-1ys9A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 8 PHE A  27
GLU A 251
SER A 248
VAL A 225
 None
 1.30A 3jx1A-1ys9A:
undetectable
3jx1B-1ys9A:
undetectable		 3jx1A-1ys9A:
20.93
3jx1B-1ys9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		5 / 12 ASP A 148
ILE A 143
ILE A 179
VAL A 177
PRO A 176
 None
 0.99A 3kpdC-1ys9A:
undetectable		 3kpdC-1ys9A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 8 PHE A  27
GLU A 251
SER A 248
VAL A 225
 None
 1.32A 3nlyA-1ys9A:
undetectable
3nlyB-1ys9A:
undetectable		 3nlyA-1ys9A:
20.93
3nlyB-1ys9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 8 PHE A  27
GLU A 251
SER A 248
VAL A 225
 None
 1.29A 3rqlA-1ys9A:
undetectable
3rqlB-1ys9A:
undetectable		 3rqlA-1ys9A:
20.93
3rqlB-1ys9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 5 VAL A 118
GLU A 111
LYS A 138
PHE A 142
 None
 1.18A 3rv5C-1ys9A:
undetectable
3rv5D-1ys9A:
undetectable		 3rv5C-1ys9A:
16.27
3rv5D-1ys9A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.13A 3wrhE-1ys9A:
undetectable		 3wrhE-1ys9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.11A 3wrjE-1ys9A:
undetectable		 3wrjE-1ys9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		5 / 12 PHE A 142
GLY A 119
ILE A 143
PHE A 178
ALA A 163
 None
 1.07A 4a6dA-1ys9A:
3.0		 4a6dA-1ys9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		5 / 12 PHE A 142
GLY A 119
ILE A 143
PHE A 178
ALA A 163
 None
 1.14A 4a6eA-1ys9A:
undetectable		 4a6eA-1ys9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 8 PHE A  27
GLU A 251
SER A 248
VAL A 225
 None
 1.33A 4capA-1ys9A:
undetectable
4capB-1ys9A:
undetectable		 4capA-1ys9A:
20.93
4capB-1ys9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 8 PHE A  27
GLU A 251
SER A 248
VAL A 225
 None
 1.28A 4d32A-1ys9A:
undetectable
4d32B-1ys9A:
undetectable		 4d32A-1ys9A:
20.93
4d32B-1ys9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		5 / 9 LEU A 191
GLY A 215
ALA A 214
GLY A 205
ILE A 223
 None
 1.04A 4dqcB-1ys9A:
undetectable		 4dqcB-1ys9A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.07A 4ek1A-1ys9A:
0.0		 4ek1A-1ys9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.11A 4g3rA-1ys9A:
0.0		 4g3rA-1ys9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.14A 4g3rB-1ys9A:
undetectable		 4g3rB-1ys9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.16A 4kkyX-1ys9A:
0.0		 4kkyX-1ys9A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 5 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.12A 4l49A-1ys9A:
undetectable		 4l49A-1ys9A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 PHE A  27
LEU A 246
VAL A 225
VAL A 202
 None
 1.12A 4l4cA-1ys9A:
undetectable		 4l4cA-1ys9A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		5 / 12 ALA A  23
ASP A 206
LEU A  10
LEU A  56
ILE A  28
 None
 1.02A 4m2xA-1ys9A:
undetectable		 4m2xA-1ys9A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		5 / 12 ALA A  23
ASP A 206
LEU A  10
LEU A  56
ILE A  28
 None
 1.01A 4m2xE-1ys9A:
3.7		 4m2xE-1ys9A:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 8 PHE A  27
GLU A 251
SER A 248
VAL A 225
 None
 1.31A 4v3yA-1ys9A:
undetectable
4v3yB-1ys9A:
undetectable		 4v3yA-1ys9A:
20.93
4v3yB-1ys9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		5 / 9 LEU A 191
GLY A 215
ALA A 214
GLY A 205
ILE A 223
 None
 1.02A 5kr0B-1ys9A:
undetectable		 5kr0B-1ys9A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 8 SER A 248
VAL A 225
PHE A  27
GLU A 251
 None
 1.35A 5uo7A-1ys9A:
undetectable
5uo7B-1ys9A:
undetectable		 5uo7A-1ys9A:
20.53
5uo7B-1ys9A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 ILE A 212
ILE A  21
LEU A 249
PHE A  60
 None
 0.97A 5vkqB-1ys9A:
undetectable
5vkqC-1ys9A:
undetectable		 5vkqB-1ys9A:
10.28
5vkqC-1ys9A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		4 / 6 ILE A 212
ILE A  21
LEU A 249
PHE A  60
 None
 0.99A 5vkqC-1ys9A:
undetectable
5vkqD-1ys9A:
undetectable		 5vkqC-1ys9A:
10.28
5vkqD-1ys9A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1ys9 PROTEIN SPY1043
(Streptococcus
pyogenes) 		3 / 3 VAL A  62
GLU A  63
ILE A  28
 None
 0.63A 6f7lB-1ys9A:
undetectable		 6f7lB-1ys9A:
19.42