SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ysp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1ysp TRANSCRIPTIONAL
REGULATOR KDGR
(Escherichia
coli) 		5 / 12 ALA A  67
GLY A 137
GLY A 110
ALA A 136
LEU A   3
 None
 1.09A 2plwA-1yspA:
undetectable		 2plwA-1yspA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1ysp TRANSCRIPTIONAL
REGULATOR KDGR
(Escherichia
coli) 		4 / 8 VAL A  81
TYR A  83
LEU A 101
LEU A  66
 None
 1.04A 4jtrA-1yspA:
undetectable		 4jtrA-1yspA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ysp TRANSCRIPTIONAL
REGULATOR KDGR
(Escherichia
coli) 		4 / 7 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.90A 5b1aA-1yspA:
undetectable
5b1aJ-1yspA:
undetectable		 5b1aA-1yspA:
15.37
5b1aJ-1yspA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ysp TRANSCRIPTIONAL
REGULATOR KDGR
(Escherichia
coli) 		4 / 7 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.92A 5b3sA-1yspA:
1.2
5b3sJ-1yspA:
undetectable		 5b3sA-1yspA:
15.37
5b3sJ-1yspA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ysp TRANSCRIPTIONAL
REGULATOR KDGR
(Escherichia
coli) 		4 / 7 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.91A 5xdqN-1yspA:
undetectable
5xdqW-1yspA:
undetectable		 5xdqN-1yspA:
15.37
5xdqW-1yspA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 1ysp TRANSCRIPTIONAL
REGULATOR KDGR
(Escherichia
coli) 		4 / 8 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.90A 5xdxN-1yspA:
undetectable
5xdxW-1yspA:
undetectable		 5xdxN-1yspA:
15.37
5xdxW-1yspA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ysp TRANSCRIPTIONAL
REGULATOR KDGR
(Escherichia
coli) 		4 / 8 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.94A 5zcoA-1yspA:
undetectable
5zcoJ-1yspA:
undetectable		 5zcoA-1yspA:
15.37
5zcoJ-1yspA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ysp TRANSCRIPTIONAL
REGULATOR KDGR
(Escherichia
coli) 		4 / 7 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.91A 5zcpA-1yspA:
undetectable
5zcpJ-1yspA:
undetectable		 5zcpA-1yspA:
15.37
5zcpJ-1yspA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ysp TRANSCRIPTIONAL
REGULATOR KDGR
(Escherichia
coli) 		4 / 7 ILE A  35
LEU A  24
ARG A  53
LEU A  65
 None
 0.87A 5zcqA-1yspA:
undetectable
5zcqJ-1yspA:
undetectable		 5zcqA-1yspA:
15.37
5zcqJ-1yspA:
17.37