SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ysq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ
(Escherichia
coli) 		3 / 3 SER A 153
ARG A 154
GLN A 157
 None
 1.02A 2xnrA-1ysqA:
undetectable		 2xnrA-1ysqA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ
(Escherichia
coli) 		4 / 8 TYR A 144
ILE A  11
ILE A   9
HIS A  15
 None
 0.98A 2zm8A-1ysqA:
undetectable		 2zm8A-1ysqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ
(Escherichia
coli) 		4 / 8 TYR A 144
ILE A  11
ILE A   9
HIS A  15
 None
 0.97A 2zmaA-1ysqA:
undetectable		 2zmaA-1ysqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ
(Escherichia
coli) 		4 / 4 LEU A 155
GLY A 159
LEU A 163
GLU A 160
 None
 1.07A 3tgvB-1ysqA:
undetectable		 3tgvB-1ysqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ
(Escherichia
coli) 		4 / 7 LEU A  94
ASN A 124
ILE A  70
THR A  98
 None
 0.99A 4eyrA-1ysqA:
undetectable		 4eyrA-1ysqA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ
(Escherichia
coli) 		5 / 12 ALA A  54
MET A  60
ILE A  40
ILE A  56
THR A  52
 None
PO4  A 301 (-3.6A)
None
None
None
 1.08A 4pstA-1ysqA:
undetectable		 4pstA-1ysqA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ
(Escherichia
coli) 		3 / 3 SER A 147
ALA A 145
VAL A 135
 PO4  A 301 (-2.8A)
None
None
 0.65A 4x20C-1ysqA:
undetectable		 4x20C-1ysqA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ
(Escherichia
coli) 		5 / 11 GLY A  75
PRO A  77
ALA A  73
TYR A  71
VAL A 142
 PO4  A 303 (-3.9A)
None
None
PO4  A 303 (-4.4A)
PO4  A 303 (-4.0A)
 1.41A 5c8tB-1ysqA:
0.0		 5c8tB-1ysqA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ
(Escherichia
coli) 		3 / 3 ALA A  66
VAL A 142
TYR A  71
 PO4  A 301 (-3.6A)
PO4  A 303 (-4.0A)
PO4  A 303 (-4.4A)
 0.60A 5zmqH-1ysqA:
undetectable		 5zmqH-1ysqA:
23.90