SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ysr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		5 / 9 ASP A 380
ALA A 436
VAL A 385
GLY A 358
GLY A 382
 None
 1.29A 1bcuH-1ysrA:
undetectable		 1bcuH-1ysrA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 309
ALA A 367
GLY A 373
VAL A 304
ILE A 306
 None
None
TRS  A1001 (-3.3A)
None
None
 1.14A 1d4yB-1ysrA:
undetectable		 1d4yB-1ysrA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 328
ALA A 367
LEU A 365
VAL A 374
 None
 1.01A 1sn5A-1ysrA:
undetectable		 1sn5A-1ysrA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 436
ASP A 380
GLY A 435
GLY A 384
ALA A 354
 None
 1.12A 2c49A-1ysrA:
undetectable		 2c49A-1ysrA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 390
GLU A 395
ALA A 426
ALA A 416
 None
 0.87A 2ejfA-1ysrA:
undetectable		 2ejfA-1ysrA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 365
LEU A 328
ARG A 312
 None
 0.69A 3hcnB-1ysrA:
undetectable		 3hcnB-1ysrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 328
ALA A 367
LEU A 365
VAL A 374
 None
 0.99A 3ozkB-1ysrA:
undetectable		 3ozkB-1ysrA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 328
ALA A 367
LEU A 365
VAL A 374
 None
 0.93A 4iizB-1ysrA:
undetectable		 4iizB-1ysrA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 426
LEU A 410
LEU A 438
LEU A 412
ARG A 390
 None
 1.19A 4x30A-1ysrA:
undetectable		 4x30A-1ysrA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 436
VAL A 385
GLY A 382
ALA A 360
GLY A 358
 None
 1.29A 4zjzB-1ysrA:
undetectable		 4zjzB-1ysrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 435
GLY A 434
LEU A 433
ALA A 350
ASP A 379
 None
 0.77A 5c0oF-1ysrA:
undetectable		 5c0oF-1ysrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 309
ALA A 367
GLY A 373
VAL A 304
ILE A 306
 None
None
TRS  A1001 (-3.3A)
None
None
 1.18A 5kr2B-1ysrA:
undetectable		 5kr2B-1ysrA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 358
ASP A 380
ILE A 351
 None
 0.61A 6dgxB-1ysrA:
undetectable		 6dgxB-1ysrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 359
ASP A 380
ILE A 351
 None
 0.47A 6dgxB-1ysrA:
undetectable		 6dgxB-1ysrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 378
LEU A 365
THR A 361
LEU A 324
 None
 0.88A 6nmpA-1ysrA:
undetectable
6nmpJ-1ysrA:
undetectable		 6nmpA-1ysrA:
14.09
6nmpJ-1ysrA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 378
LEU A 365
THR A 361
LEU A 324
 None
 0.88A 6nmpN-1ysrA:
0.0
6nmpW-1ysrA:
undetectable		 6nmpN-1ysrA:
14.09
6nmpW-1ysrA:
16.00