SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yt3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		3 / 3 ILE A 310
LEU A 313
VAL A 317
 None
 0.24A 1mz9B-1yt3A:
undetectable		 1mz9B-1yt3A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		5 / 12 VAL A  92
ILE A  60
ILE A  55
VAL A 156
ILE A   6
 None
 1.25A 1r5lA-1yt3A:
undetectable		 1r5lA-1yt3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		5 / 12 LEU A 328
ALA A 329
LEU A 353
LEU A 369
PHE A 307
 None
 1.13A 1s9pB-1yt3A:
undetectable		 1s9pB-1yt3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		3 / 3 GLU A 241
GLU A 267
LEU A 233
 None
SO4  A 606 ( 4.8A)
None
 0.66A 1v8bA-1yt3A:
undetectable		 1v8bA-1yt3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		3 / 3 GLU A 241
GLU A 267
LEU A 233
 None
SO4  A 606 ( 4.8A)
None
 0.71A 1v8bB-1yt3A:
undetectable		 1v8bB-1yt3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		3 / 3 TRP A 116
GLU A 124
TYR A 125
 None
 1.23A 2a3aA-1yt3A:
undetectable		 2a3aA-1yt3A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		5 / 12 ALA A 152
ALA A 153
ASN A   2
LEU A  52
LEU A  43
 None
 1.03A 2aclA-1yt3A:
undetectable
2aclE-1yt3A:
undetectable		 2aclA-1yt3A:
22.87
2aclE-1yt3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		4 / 5 LEU A 290
GLN A 213
THR A 211
THR A 284
 None
 1.24A 2zj0B-1yt3A:
undetectable		 2zj0B-1yt3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		4 / 4 LEU A 290
GLN A 213
THR A 211
THR A 284
 None
 1.34A 2zj0D-1yt3A:
undetectable		 2zj0D-1yt3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		4 / 8 ASP A  28
ASP A  85
GLN A 104
ARG A  33
 ZN  A1001 ( 2.9A)
ZN  A1002 (-2.1A)
None
None
 1.00A 3s3nA-1yt3A:
undetectable		 3s3nA-1yt3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		4 / 7 ASP A  28
ASP A  85
GLN A 104
ARG A  33
 ZN  A1001 ( 2.9A)
ZN  A1002 (-2.1A)
None
None
 1.01A 3s3oA-1yt3A:
undetectable		 3s3oA-1yt3A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		4 / 8 ILE A 310
LEU A 313
GLY A 359
TRP A 357
 None
 0.89A 3w1wA-1yt3A:
undetectable		 3w1wA-1yt3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		5 / 8 ALA A 329
LEU A 337
LEU A 338
LEU A 313
LEU A 366
 None
 1.29A 5jqbA-1yt3A:
undetectable
5jqbB-1yt3A:
undetectable		 5jqbA-1yt3A:
22.19
5jqbB-1yt3A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		4 / 6 LEU A 275
VAL A 279
LEU A 258
GLU A 242
 None
 0.96A 5tudD-1yt3A:
undetectable		 5tudD-1yt3A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1yt3 RIBONUCLEASE D
(Escherichia
coli) 		4 / 5 LEU A 159
LEU A 160
MET A   1
TYR A 151
 None
None
None
ZN  A1001 (-3.9A)
 1.45A 5uc3A-1yt3A:
undetectable		 5uc3A-1yt3A:
12.71