SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 11 GLU A  14
GLY A  50
THR A  53
LEU A  18
GLY A  69
 None
SO4  A 317 (-3.8A)
None
None
None
 1.34A 1i7qA-1yt5A:
undetectable		 1i7qA-1yt5A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 12 GLY A  52
GLY A  50
ILE A  45
LEU A   6
ALA A  57
 SO4  A 317 (-4.6A)
SO4  A 317 (-3.8A)
None
None
None
 1.02A 1v2xA-1yt5A:
undetectable		 1v2xA-1yt5A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		3 / 3 ASP A 242
TYR A 243
GLU A 174
 None
 0.86A 1vm1A-1yt5A:
undetectable		 1vm1A-1yt5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 10 ILE A 134
ALA A 148
ASN A 210
ALA A 184
ILE A 224
 None
 1.06A 2aclC-1yt5A:
undetectable		 2aclC-1yt5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 11 ILE A 134
ALA A 148
ASN A 210
ALA A 184
ILE A 224
 None
 1.04A 2aclE-1yt5A:
undetectable		 2aclE-1yt5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1290_1
(FICOLIN-2)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 9 VAL A 246
LEU A  78
SER A  80
ARG A 103
GLU A 101
 None
 1.50A 2j2pD-1yt5A:
0.0
2j2pE-1yt5A:
0.0		 2j2pD-1yt5A:
22.11
2j2pE-1yt5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		4 / 8 VAL A 203
VAL A 202
LYS A 200
ARG A 223
 None
 0.89A 3bjwA-1yt5A:
undetectable		 3bjwA-1yt5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 12 VAL A 152
SER A 154
THR A 122
ILE A 108
ALA A 117
 None
 1.11A 3ddyA-1yt5A:
undetectable		 3ddyA-1yt5A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 12 ILE A 134
ALA A 148
ASN A 210
ALA A 184
ILE A 224
 None
 1.08A 3e00A-1yt5A:
undetectable		 3e00A-1yt5A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 9 ILE A  22
ILE A   3
LYS A   1
LEU A  93
LEU A  90
 None
 1.48A 3f78B-1yt5A:
3.7		 3f78B-1yt5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 11 SER A 181
ILE A 180
VAL A 136
VAL A 201
ILE A 134
 None
 1.27A 3rf4A-1yt5A:
undetectable
3rf4C-1yt5A:
undetectable		 3rf4A-1yt5A:
17.44
3rf4C-1yt5A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 11 ILE A 134
SER A 181
ILE A 180
VAL A 136
VAL A 201
 None
 1.28A 3rf4A-1yt5A:
undetectable
3rf4B-1yt5A:
undetectable		 3rf4A-1yt5A:
17.44
3rf4B-1yt5A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		5 / 11 ILE A 134
SER A 181
ILE A 180
VAL A 136
VAL A 201
 None
 1.26A 3rf4B-1yt5A:
undetectable
3rf4C-1yt5A:
undetectable		 3rf4B-1yt5A:
17.44
3rf4C-1yt5A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		4 / 7 TYR A  81
VAL A  68
PHE A  98
ILE A  22
 None
 0.98A 3zjqA-1yt5A:
undetectable		 3zjqA-1yt5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		4 / 6 GLU A 204
GLU A 135
GLU A 137
SER A 143
 None
 1.41A 4kr3A-1yt5A:
4.1		 4kr3A-1yt5A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		3 / 3 ILE A 224
ILE A 180
MET A 211
 None
 0.71A 5i9yA-1yt5A:
undetectable		 5i9yA-1yt5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		3 / 3 VAL A 246
GLU A 174
GLU A 101
 None
 0.67A 5jsdB-1yt5A:
undetectable
5jsdC-1yt5A:
undetectable		 5jsdB-1yt5A:
15.59
5jsdC-1yt5A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1yt5 INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE
(Thermotoga
maritima) 		3 / 3 TRP A 104
ILE A 106
GLU A 179
 None
 0.87A 6hcxA-1yt5A:
undetectable		 6hcxA-1yt5A:
15.66