SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 467
VAL A 469
TRP A 468
 None
 0.82A 1bdwA-1yt8A:
undetectable
1bdwB-1yt8A:
undetectable		 1bdwA-1yt8A:
4.30
1bdwB-1yt8A:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A 524
PHE A  42
ASP A 521
PRO A 115
 None
 1.31A 1ilqA-1yt8A:
0.0
1ilqC-1yt8A:
undetectable		 1ilqA-1yt8A:
9.28
1ilqC-1yt8A:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 202
ILE A 200
TRP A 341
VAL A 311
 None
 1.00A 1rs7A-1yt8A:
undetectable		 1rs7A-1yt8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 446
LEU A 442
GLN A 419
PRO A  47
LEU A  75
 None
None
None
GOL  A 541 (-4.6A)
None
 1.31A 1u72A-1yt8A:
undetectable		 1u72A-1yt8A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 119
GLY A 120
LEU A 310
LEU A 342
LEU A 325
 None
 0.88A 2nxeA-1yt8A:
undetectable		 2nxeA-1yt8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 119
GLY A 120
LEU A 310
LEU A 342
LEU A 325
 None
 0.87A 2nxeB-1yt8A:
undetectable		 2nxeB-1yt8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 GLU A 313
ARG A 154
HIS A 316
GLU A 495
ASP A 156
 None
None
GOL  A 541 (-3.7A)
None
None
 1.23A 2qeoB-1yt8A:
0.0		 2qeoB-1yt8A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 517
THR A 523
TRP A 101
 None
 0.83A 2rctA-1yt8A:
undetectable		 2rctA-1yt8A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 299
SER A 302
TYR A 294
VAL A 328
 None
 1.08A 2uz2A-1yt8A:
undetectable		 2uz2A-1yt8A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  68
ASP A  28
LEU A  51
LEU A  48
ALA A  79
 None
 0.98A 2v3kA-1yt8A:
undetectable		 2v3kA-1yt8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 132
ALA A 139
LEU A 141
ALA A 145
 None
 0.95A 2vcvB-1yt8A:
undetectable		 2vcvB-1yt8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 132
ALA A 139
LEU A 141
ALA A 145
 None
 0.93A 2vcvK-1yt8A:
undetectable		 2vcvK-1yt8A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 119
GLY A 120
LEU A 310
LEU A 342
LEU A 325
 None
 0.91A 2zbpA-1yt8A:
undetectable		 2zbpA-1yt8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 217
GLY A 224
ILE A 190
SER A 131
LEU A 132
 None
 0.81A 3gyqB-1yt8A:
undetectable		 3gyqB-1yt8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 342
LEU A 325
ARG A 303
 None
 0.63A 3hcnB-1yt8A:
2.9		 3hcnB-1yt8A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ASN A 403
ALA A 400
ALA A 402
ARG A 489
 None
 1.41A 3kp2B-1yt8A:
undetectable		 3kp2B-1yt8A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  41
ALA A  43
LEU A  18
GLY A 106
LEU A 108
 None
 1.22A 3uudA-1yt8A:
undetectable		 3uudA-1yt8A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 199
ASN A 192
GLY A 308
GLN A 312
 None
None
None
SO3  A 540 ( 3.8A)
 0.98A 4af0A-1yt8A:
undetectable		 4af0A-1yt8A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 220
ARG A 196
GLY A 506
TYR A 507
 None
 0.96A 4cp3A-1yt8A:
undetectable
4cp3B-1yt8A:
undetectable		 4cp3A-1yt8A:
13.70
4cp3B-1yt8A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 202
ILE A 200
TRP A 341
VAL A 311
 None
 0.99A 4d33A-1yt8A:
undetectable		 4d33A-1yt8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 202
ILE A 200
TRP A 341
VAL A 311
 None
 1.00A 4d33B-1yt8A:
undetectable		 4d33B-1yt8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 202
ILE A 200
TRP A 341
VAL A 311
 None
 1.01A 4d39B-1yt8A:
undetectable		 4d39B-1yt8A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A 302
LEU A 299
PHE A 360
TYR A 294
 None
 1.10A 4j7uD-1yt8A:
undetectable		 4j7uD-1yt8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 202
ILE A 200
TRP A 341
VAL A 311
 None
 1.04A 4kcnA-1yt8A:
undetectable		 4kcnA-1yt8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 228
GLU A 135
GLN A 138
ILE A 149
 None
 0.86A 4kttB-1yt8A:
undetectable		 4kttB-1yt8A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 228
GLU A 135
GLN A 138
ILE A 149
 None
 0.75A 4kttD-1yt8A:
undetectable		 4kttD-1yt8A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 SER A  49
SER A 418
ILE A 487
GLU A  73
 None
 1.19A 4ms4A-1yt8A:
3.0		 4ms4A-1yt8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 334
ASP A 330
ARG A 177
 None
 0.84A 4mx0A-1yt8A:
undetectable		 4mx0A-1yt8A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 228
GLU A 135
GLN A 138
ILE A 149
 None
 0.79A 4ndnD-1yt8A:
undetectable		 4ndnD-1yt8A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 339
GLY A 307
ASP A 287
GLU A 293
ALA A 172
 None
 1.18A 4pclA-1yt8A:
undetectable		 4pclA-1yt8A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 SER A 205
SER A 199
GLU A 157
ASP A 151
GLY A 308
 None
 1.48A 4qb9F-1yt8A:
0.2		 4qb9F-1yt8A:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 PRO A 369
SER A 302
GLU A 362
ASP A 330
 None
 1.31A 4uacA-1yt8A:
undetectable		 4uacA-1yt8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 8 LEU A 327
VAL A 351
ALA A 339
LEU A 342
GLY A 307
 None
 1.12A 4zauA-1yt8A:
undetectable		 4zauA-1yt8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 511
TYR A 507
ALA A 194
TYR A 494
 SO3  A 540 ( 4.7A)
None
SO3  A 540 (-3.4A)
None
 0.89A 4zz8A-1yt8A:
undetectable		 4zz8A-1yt8A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ILE A 163
PRO A 164
ILE A 149
 None
 0.45A 5hw8F-1yt8A:
undetectable		 5hw8F-1yt8A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 202
SER A 340
VAL A 191
VAL A 175
LEU A 174
 None
 1.19A 5kocB-1yt8A:
undetectable		 5kocB-1yt8A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 288
ASP A 287
SER A 338
THR A 247
GLN A 245
 None
 1.44A 5m50B-1yt8A:
undetectable		 5m50B-1yt8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 288
ASP A 287
SER A 338
THR A 247
GLN A 245
 None
 1.44A 5m54B-1yt8A:
undetectable		 5m54B-1yt8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 8 ALA A 228
GLU A 135
GLN A 138
ILE A 149
 None
 0.79A 5t8sA-1yt8A:
undetectable		 5t8sA-1yt8A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_ACTA404_0
(FERREDOXIN--NADP
REDUCTASE)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 4 THR A 222
TYR A 158
LEU A 232
MET A 161
 None
 1.39A 5vw9A-1yt8A:
0.8		 5vw9A-1yt8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A 112
TYR A 490
GLU A 313
 None
 0.83A 5zmqD-1yt8A:
undetectable
5zmqE-1yt8A:
undetectable		 5zmqD-1yt8A:
17.05
5zmqE-1yt8A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 407
LYS A 406
ARG A 492
 None
 1.13A 6c06D-1yt8A:
undetectable		 6c06D-1yt8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 496
ASN A 499
ASP A 498
ARG A 491
 None
 0.84A 6dwdA-1yt8A:
undetectable
6dwdC-1yt8A:
undetectable		 6dwdA-1yt8A:
21.05
6dwdC-1yt8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 496
ASN A 499
ASP A 498
ARG A 491
 None
 0.86A 6dwdB-1yt8A:
undetectable
6dwdD-1yt8A:
undetectable		 6dwdB-1yt8A:
21.05
6dwdD-1yt8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 491
GLY A 496
ASN A 499
ASP A 498
 None
 0.89A 6dwjB-1yt8A:
undetectable
6dwjD-1yt8A:
undetectable		 6dwjB-1yt8A:
21.05
6dwjD-1yt8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 395
LEU A 388
ALA A 412
GLY A 411
LEU A 384
 None
 0.86A 6f6iA-1yt8A:
undetectable
6f6iB-1yt8A:
undetectable		 6f6iA-1yt8A:
12.98
6f6iB-1yt8A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1yt8 THIOSULFATE
SULFURTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 511
GLY A 195
ASP A 111
ASN A 499
GLY A 496
 SO3  A 540 ( 4.7A)
SO3  A 540 (-3.1A)
None
None
None
 1.14A 6gneB-1yt8A:
undetectable		 6gneB-1yt8A:
22.13