SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ytl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 171
LEU A 174
LEU A 111
PRO A  38
VAL A  64
 None
 1.04A 1hrkA-1ytlA:
3.5		 1hrkA-1ytlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		4 / 5 GLU A  49
LEU A 164
ASP A 168
LEU A 171
 None
 1.20A 1n13B-1ytlA:
undetectable
1n13C-1ytlA:
undetectable		 1n13B-1ytlA:
22.29
1n13C-1ytlA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 171
LEU A 174
LEU A 111
PRO A  38
VAL A  64
 None
 1.12A 2hrcB-1ytlA:
3.6		 2hrcB-1ytlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 171
LEU A 174
LEU A 111
PRO A  38
VAL A  64
 None
 0.97A 2pnjA-1ytlA:
3.6		 2pnjA-1ytlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 171
LEU A 174
LEU A 111
PRO A  38
VAL A  64
 None
 0.93A 2po7A-1ytlA:
3.2		 2po7A-1ytlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 171
LEU A 174
LEU A 111
PRO A  38
VAL A  64
 None
 0.92A 2qd4A-1ytlA:
3.4		 2qd4A-1ytlA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 10 LEU A  88
THR A  67
GLY A 116
ASP A 142
ILE A  41
 None
 1.23A 3bexC-1ytlA:
1.9
3bexD-1ytlA:
1.8		 3bexC-1ytlA:
21.18
3bexD-1ytlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 10 GLY A 116
ASP A 142
ILE A  41
LEU A  88
THR A  67
 None
 1.22A 3bexE-1ytlA:
2.3
3bexF-1ytlA:
1.8		 3bexE-1ytlA:
21.18
3bexF-1ytlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 11 LEU A  88
THR A  67
GLY A 116
ASP A 142
ILE A  41
 None
 1.23A 3bexE-1ytlA:
2.3
3bexF-1ytlA:
1.9		 3bexE-1ytlA:
21.18
3bexF-1ytlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 11 GLY A 116
ASP A 142
ILE A  41
LEU A  88
THR A  67
 None
 1.23A 3bf1A-1ytlA:
1.9
3bf1B-1ytlA:
1.7		 3bf1A-1ytlA:
21.18
3bf1B-1ytlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  88
THR A  67
GLY A 116
ASP A 142
ILE A  41
 None
 1.21A 3bf1A-1ytlA:
2.2
3bf1B-1ytlA:
2.3		 3bf1A-1ytlA:
21.18
3bf1B-1ytlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 11 GLY A 116
ASP A 142
ILE A  41
LEU A  88
THR A  67
 None
 1.22A 3bf1C-1ytlA:
2.3
3bf1D-1ytlA:
1.7		 3bf1C-1ytlA:
21.18
3bf1D-1ytlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 11 LEU A  88
THR A  67
GLY A 116
ASP A 142
ILE A  41
 None
 1.24A 3bf1C-1ytlA:
2.3
3bf1D-1ytlA:
1.8		 3bf1C-1ytlA:
21.18
3bf1D-1ytlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 11 GLY A 116
ASP A 142
ILE A  41
LEU A  88
THR A  67
 None
 1.22A 3bf1E-1ytlA:
1.9
3bf1F-1ytlA:
2.2		 3bf1E-1ytlA:
21.18
3bf1F-1ytlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 11 LEU A  88
THR A  67
GLY A 116
ASP A 142
ILE A  41
 None
 1.23A 3bf1E-1ytlA:
1.9
3bf1F-1ytlA:
2.2		 3bf1E-1ytlA:
21.18
3bf1F-1ytlA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		4 / 8 TYR A 163
VAL A  28
PHE A  57
LEU A 167
 None
 1.04A 4f8hA-1ytlA:
undetectable
4f8hB-1ytlA:
undetectable		 4f8hA-1ytlA:
20.06
4f8hB-1ytlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		4 / 8 TYR A 163
VAL A  28
PHE A  57
LEU A 167
 None
 1.10A 4f8hB-1ytlA:
undetectable
4f8hC-1ytlA:
undetectable		 4f8hB-1ytlA:
20.06
4f8hC-1ytlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		4 / 8 TYR A 163
VAL A  28
PHE A  57
LEU A 167
 None
 1.07A 4f8hC-1ytlA:
undetectable
4f8hD-1ytlA:
undetectable		 4f8hC-1ytlA:
20.06
4f8hD-1ytlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		4 / 8 TYR A 163
VAL A  28
PHE A  57
LEU A 167
 None
 1.05A 4f8hD-1ytlA:
undetectable
4f8hE-1ytlA:
undetectable		 4f8hD-1ytlA:
20.06
4f8hE-1ytlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		4 / 8 VAL A  28
PHE A  57
LEU A 167
TYR A 163
 None
 1.06A 4f8hA-1ytlA:
undetectable
4f8hE-1ytlA:
undetectable		 4f8hA-1ytlA:
20.06
4f8hE-1ytlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  88
THR A  67
GLY A 116
ASP A 142
ILE A  41
 None
 1.23A 4o5fA-1ytlA:
2.1
4o5fB-1ytlA:
undetectable		 4o5fA-1ytlA:
21.02
4o5fB-1ytlA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 9 TYR A 109
ILE A  62
THR A  67
LEU A  91
LEU A  95
 None
 1.27A 4ze0A-1ytlA:
undetectable		 4ze0A-1ytlA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		4 / 8 VAL A  54
PHE A  74
GLY A  43
MET A  46
 None
 0.69A 4zjzA-1ytlA:
3.3		 4zjzA-1ytlA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 116
ASP A 142
ILE A  41
LEU A  88
THR A  67
 None
 1.22A 5b8hA-1ytlA:
2.6
5b8hB-1ytlA:
2.0		 5b8hA-1ytlA:
20.49
5b8hB-1ytlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		4 / 8 LEU A 113
PHE A 153
GLY A  25
LEU A 174
 None
 0.86A 5eseA-1ytlA:
undetectable		 5eseA-1ytlA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  40
LEU A 113
ALA A 138
SER A 152
LEU A  22
 None
 1.23A 5mwyA-1ytlA:
undetectable		 5mwyA-1ytlA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1ytl ACETYL-COA
DECARBOXYLASE/SYNTHA
SE COMPLEX EPSILON
SUBUNIT 2
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  88
PHE A  74
VAL A  83
VAL A  54
LEU A 126
 None
 1.13A 6djzC-1ytlA:
undetectable		 6djzC-1ytlA:
20.26