SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ytq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		5 / 12 ASP A 125
ASP A 126
VAL A 128
ILE A 109
VAL A 186
 None
 0.85A 1k6cB-1ytqA:
undetectable		 1k6cB-1ytqA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		5 / 11 ASP A 125
ASP A 126
VAL A 128
ILE A 109
VAL A 186
 None
 0.84A 1t7jA-1ytqA:
undetectable		 1t7jA-1ytqA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		4 / 5 VAL A  59
GLY A  60
VAL A  72
TRP A  84
 None
 1.20A 1tkqB-1ytqA:
undetectable		 1tkqB-1ytqA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		5 / 11 TYR A  61
GLY A  60
TRP A  58
LEU A  40
ILE A  99
 None
 1.35A 2a58A-1ytqA:
undetectable
2a58E-1ytqA:
undetectable		 2a58A-1ytqA:
20.75
2a58E-1ytqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		5 / 12 ILE A  99
TYR A  61
GLY A  60
TRP A  58
LEU A  40
 None
 1.31A 2a58A-1ytqA:
undetectable
2a58B-1ytqA:
undetectable		 2a58A-1ytqA:
20.75
2a58B-1ytqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		5 / 12 ILE A  99
TYR A  61
GLY A  60
TRP A  58
LEU A  40
 None
 1.32A 2a58D-1ytqA:
undetectable
2a58E-1ytqA:
undetectable		 2a58D-1ytqA:
20.75
2a58E-1ytqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		5 / 12 ASP A 125
ASP A 126
VAL A 128
ILE A 109
VAL A 186
 None
 0.79A 3el5B-1ytqA:
undetectable		 3el5B-1ytqA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		4 / 4 GLN A 182
PRO A 181
VAL A 140
GLU A 112
 None
 1.18A 3huoA-1ytqA:
undetectable		 3huoA-1ytqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		5 / 9 TYR A 170
VAL A 145
GLY A 168
VAL A 151
GLN A 162
 None
 1.41A 3kmoA-1ytqA:
undetectable		 3kmoA-1ytqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		4 / 7 ASP A 125
ASP A 126
VAL A 128
ILE A 109
 None
 0.73A 3t3cA-1ytqA:
undetectable		 3t3cA-1ytqA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		3 / 3 ASN A  25
GLU A  24
ARG A  80
 None
 1.10A 3wxoA-1ytqA:
undetectable		 3wxoA-1ytqA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 1ytq BETA CRYSTALLIN B2
(Homo
sapiens) 		4 / 7 PHE A  71
PHE A  73
ALA A  48
LEU A  96
 None
 0.92A 4ejgA-1ytqA:
undetectable		 4ejgA-1ytqA:
17.85