SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		4 / 6 VAL A 251
GLY A 252
LEU A 427
GLU A 430
 None
 1.02A 1fduD-1ytsA:
undetectable		 1fduD-1ytsA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 12 SER A 428
ASN A 467
VAL A 445
ALA A 411
VAL A 251
 None
 1.18A 2nniA-1ytsA:
undetectable		 2nniA-1ytsA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		4 / 5 LEU A 282
ALA A 283
LEU A 285
MET A 298
 None
 1.16A 2oaxA-1ytsA:
undetectable		 2oaxA-1ytsA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		3 / 3 ASN A 227
ASN A 245
ARG A 440
 None
 0.66A 2rlcA-1ytsA:
undetectable		 2rlcA-1ytsA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		4 / 5 PRO A 464
THR A 254
VAL A 251
GLY A 252
 None
 0.96A 3elzA-1ytsA:
undetectable		 3elzA-1ytsA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 12 ILE A 414
VAL A 372
LEU A 285
ALA A 329
LEU A 323
 None
 1.07A 3ozuA-1ytsA:
undetectable		 3ozuA-1ytsA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 11 TYR A 248
THR A 238
LEU A 244
ALA A 258
ILE A 249
 None
 1.11A 3qelA-1ytsA:
3.2
3qelB-1ytsA:
undetectable		 3qelA-1ytsA:
21.00
3qelB-1ytsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 12 CYH A 259
SER A 403
ALA A 286
LEU A 282
MET A 273
 None
SO4  A   1 ( 2.8A)
None
None
None
 1.49A 3qt0A-1ytsA:
undetectable		 3qt0A-1ytsA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		4 / 4 ASN A 424
SER A 362
LEU A 457
THR A 254
 None
 1.49A 4an2A-1ytsA:
undetectable		 4an2A-1ytsA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		4 / 5 LEU A 204
ARG A 437
ILE A 249
ASN A 424
 None
 1.28A 4i00A-1ytsA:
undetectable		 4i00A-1ytsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 12 GLN A 435
GLY A 415
ASP A 421
ASN A 424
ALA A 369
 None
 1.14A 4pclA-1ytsA:
undetectable		 4pclA-1ytsA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 10 TYR A 248
THR A 238
LEU A 244
ALA A 258
ILE A 249
 None
 1.08A 4pe5A-1ytsA:
2.5
4pe5B-1ytsA:
2.6		 4pe5A-1ytsA:
15.53
4pe5B-1ytsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 10 TYR A 248
THR A 238
LEU A 244
ALA A 258
ILE A 249
 None
 1.09A 4pe5C-1ytsA:
2.4
4pe5D-1ytsA:
1.7		 4pe5C-1ytsA:
15.53
4pe5D-1ytsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 11 TYR A 248
THR A 238
LEU A 244
ALA A 258
ILE A 249
 None
 1.12A 5ewjA-1ytsA:
3.1
5ewjB-1ytsA:
2.0		 5ewjA-1ytsA:
20.83
5ewjB-1ytsA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 12 TYR A 248
THR A 238
LEU A 244
ALA A 258
ILE A 249
 None
 1.12A 5ewjC-1ytsA:
3.1
5ewjD-1ytsA:
2.0		 5ewjC-1ytsA:
20.83
5ewjD-1ytsA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		5 / 12 VAL A 372
ASP A 373
LEU A 282
ALA A 283
ARG A 398
 None
 1.30A 5nd4B-1ytsA:
undetectable		 5nd4B-1ytsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 1yts YERSINIA PROTEIN
TYROSINE PHOSPHATASE
(Yersinia
enterocolitica) 		4 / 8 ARG A 278
THR A 279
PRO A 280
ILE A 257
 SO4  A   2 (-4.1A)
None
None
None
 1.08A 6a4iA-1ytsA:
0.0		 6a4iA-1ytsA:
20.00