SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ytu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 12 ASN A 155
LEU A 156
GLN A 137
LEU A  33
THR A  26
 G  C   2 ( 3.3A)
G  C   2 ( 4.2A)
A  C   1 ( 3.3A)
None
None
 1.36A 1a28B-1ytuA:
undetectable		 1a28B-1ytuA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 10 VAL A 253
VAL A 246
VAL A 234
ILE A 267
LEU A 251
 None
 1.08A 1fe2A-1ytuA:
undetectable		 1fe2A-1ytuA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 371
LYS A 315
VAL A   7
GLY A 313
LEU A 346
 None
 1.25A 1s1uA-1ytuA:
2.5		 1s1uA-1ytuA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 7 LEU A  64
GLY A 110
ILE A 111
ILE A  68
 None
 0.79A 2aojB-1ytuA:
undetectable		 2aojB-1ytuA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 12 ALA A  50
ILE A 134
ILE A 104
GLY A 107
LEU A 164
 None
 1.01A 2o4nA-1ytuA:
undetectable		 2o4nA-1ytuA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 7 GLY A 110
VAL A 100
SER A 136
LEU A 130
 None
 0.82A 2oa1B-1ytuA:
undetectable		 2oa1B-1ytuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 5 ILE A 267
THR A 185
PHE A 198
TYR A 222
 None
 1.25A 3em0A-1ytuA:
undetectable		 3em0A-1ytuA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 12 GLU A 312
TYR A  13
TYR A 372
ASN A   9
VAL A   7
 None
 1.44A 3g0bA-1ytuA:
4.0		 3g0bA-1ytuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 12 GLU A 312
TYR A  13
TYR A 372
ASN A   9
VAL A   7
 None
 1.45A 3g0bB-1ytuA:
undetectable		 3g0bB-1ytuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 12 GLU A 312
TYR A  13
TYR A 372
ASN A   9
VAL A   7
 None
 1.40A 3g0bC-1ytuA:
undetectable		 3g0bC-1ytuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 12 GLU A 312
TYR A  13
TYR A 372
ASN A   9
VAL A   7
 None
 1.45A 3g0bD-1ytuA:
undetectable		 3g0bD-1ytuA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 7 ILE A 289
LEU A 268
LEU A 223
HIS A 291
 None
 0.91A 3r9vA-1ytuA:
undetectable
3r9vB-1ytuA:
undetectable		 3r9vA-1ytuA:
20.65
3r9vB-1ytuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		3 / 3 LYS A 344
PRO A 345
LEU A 346
 None
 0.86A 3tpxE-1ytuA:
undetectable		 3tpxE-1ytuA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  64
ILE A  68
ILE A  49
VAL A 114
LEU A 144
 None
 0.97A 4y0sA-1ytuA:
undetectable		 4y0sA-1ytuA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 264
THR A 265
THR A 250
LEU A 292
 None
 1.12A 5hm8A-1ytuA:
2.2		 5hm8A-1ytuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 264
THR A 265
THR A 250
LEU A 292
 None
 1.11A 5hm8B-1ytuA:
2.2		 5hm8B-1ytuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 264
THR A 265
THR A 250
LEU A 292
 None
 1.11A 5hm8C-1ytuA:
2.2		 5hm8C-1ytuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 264
THR A 265
THR A 250
LEU A 292
 None
 1.12A 5hm8D-1ytuA:
2.2		 5hm8D-1ytuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 264
THR A 265
THR A 250
LEU A 292
 None
 1.11A 5hm8E-1ytuA:
undetectable		 5hm8E-1ytuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 264
THR A 265
THR A 250
LEU A 292
 None
 1.11A 5hm8F-1ytuA:
undetectable		 5hm8F-1ytuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 264
THR A 265
THR A 250
LEU A 292
 None
 1.12A 5hm8G-1ytuA:
undetectable		 5hm8G-1ytuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 5 GLU A 264
THR A 265
THR A 250
LEU A 292
 None
 1.10A 5hm8H-1ytuA:
2.2		 5hm8H-1ytuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 12 PRO A 394
LYS A 395
VAL A 397
ILE A 401
ALA A 402
 None
 0.57A 5j2tC-1ytuA:
undetectable		 5j2tC-1ytuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		3 / 3 THR A 265
THR A 250
LEU A 292
 None
 0.60A 5m66D-1ytuA:
2.4		 5m66D-1ytuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 186
GLY A 255
GLU A 264
VAL A 233
ILE A 183
 None
 0.91A 5wz2C-1ytuA:
undetectable		 5wz2C-1ytuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 1ytu HYPOTHETICAL PROTEIN
AF1318
(Archaeoglobus
fulgidus) 		4 / 4 LEU A 157
ASP A 154
GLN A  67
VAL A 100
 None
 1.40A 6bzoF-1ytuA:
0.0		 6bzoF-1ytuA:
19.14