SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yub'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1yub RRNA
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		3 / 3 ILE A  97
ILE A  36
THR A  32
 None
 0.55A 1rg7A-1yubA:
2.7		 1rg7A-1yubA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1yub RRNA
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 THR A 134
THR A 107
VAL A 114
ILE A 122
 None
 0.96A 2qbmA-1yubA:
undetectable		 2qbmA-1yubA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1yub RRNA
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 THR A 180
ASN A 236
PHE A 235
LEU A 232
ILE A 137
 None
 1.19A 2vn0A-1yubA:
undetectable		 2vn0A-1yubA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1yub RRNA
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 ILE A  97
PHE A  89
ILE A  36
THR A  32
 None
 1.04A 3ia4A-1yubA:
undetectable		 3ia4A-1yubA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1yub RRNA
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 GLY A  37
THR A  38
GLY A  39
ASN A 100
 None
 0.90A 5k4pA-1yubA:
undetectable		 5k4pA-1yubA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 1yub RRNA
METHYLTRANSFERASE
(Streptococcus
pneumoniae) 		5 / 10 VAL A  54
GLU A  35
ALA A  48
LEU A  66
ASN A  65
 None
 1.02A 5x6yB-1yubA:
3.1		 5x6yB-1yubA:
15.22