SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yuz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		3 / 3 THR A 200
PRO A 175
THR A 198
 None
 0.95A 1dscC-1yuzA:
undetectable		 1dscC-1yuzA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_B_CUB4_0
(BETA-CARBONIC
ANHYDRASE)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		4 / 6 CYH A 192
ARG A 194
CYH A 174
PRO A 175
 FE  A 303 (-2.2A)
None
FE  A 303 (-2.2A)
None
 1.36A 1ekjA-1yuzA:
undetectable
1ekjB-1yuzA:
undetectable		 1ekjA-1yuzA:
21.46
1ekjB-1yuzA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		5 / 12 GLU A 149
HIS A 152
TYR A 156
GLU A  40
GLU A  73
 FE  A 301 ( 2.5A)
FE2  A 302 (-3.3A)
None
FE  A 301 (-1.9A)
FE2  A 302 ( 2.4A)
 0.89A 1rnrB-1yuzA:
7.7		 1rnrB-1yuzA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		4 / 7 ALA A 112
TYR A 160
ILE A  62
ASP A 105
 None
 0.89A 1upfB-1yuzA:
undetectable		 1upfB-1yuzA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		5 / 11 TYR A  47
GLY A 111
SER A 110
ILE A 116
ALA A 153
 None
 1.14A 2a58A-1yuzA:
undetectable
2a58E-1yuzA:
undetectable		 2a58A-1yuzA:
22.49
2a58E-1yuzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		5 / 12 ILE A 116
ALA A 153
TYR A  47
GLY A 111
SER A 110
 None
 1.16A 2a58A-1yuzA:
undetectable
2a58B-1yuzA:
undetectable		 2a58A-1yuzA:
22.49
2a58B-1yuzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		5 / 12 ILE A 116
ALA A 153
TYR A  47
GLY A 111
SER A 110
 None
 1.15A 2a58B-1yuzA:
undetectable
2a58C-1yuzA:
undetectable		 2a58B-1yuzA:
22.49
2a58C-1yuzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		5 / 11 ILE A 116
ALA A 153
TYR A  47
GLY A 111
SER A 110
 None
 1.15A 2a58C-1yuzA:
undetectable
2a58D-1yuzA:
undetectable		 2a58C-1yuzA:
22.49
2a58D-1yuzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		5 / 12 ILE A 116
ALA A 153
TYR A  47
GLY A 111
SER A 110
 None
 1.16A 2a58D-1yuzA:
undetectable
2a58E-1yuzA:
undetectable		 2a58D-1yuzA:
22.49
2a58E-1yuzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		3 / 3 THR A 200
PRO A 175
THR A 198
 None
 0.87A 316dC-1yuzA:
undetectable		 316dC-1yuzA:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		5 / 6 ALA A  72
ILE A 180
GLU A  40
GLU A 149
ALA A  43
 None
None
FE  A 301 (-1.9A)
FE  A 301 ( 2.5A)
FE  A 301 ( 4.6A)
 1.33A 3r9sA-1yuzA:
undetectable		 3r9sA-1yuzA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		4 / 5 ALA A 148
GLU A  73
GLU A 115
ALA A  72
 None
FE2  A 302 ( 2.4A)
FE2  A 302 (-1.9A)
None
 1.28A 3r9tC-1yuzA:
undetectable		 3r9tC-1yuzA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		5 / 10 LEU A  65
ALA A  68
GLU A  67
ARG A  55
GLY A 183
 None
 1.35A 5dxbA-1yuzA:
undetectable		 5dxbA-1yuzA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1yuz NIGERYTHRIN
(Desulfovibrio
vulgaris) 		4 / 6 SER A 110
TYR A  47
GLU A 118
THR A  69
 None
None
FE  A 301 (-2.5A)
None
 1.46A 6djzA-1yuzA:
undetectable		 6djzA-1yuzA:
21.94