SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 LEU I 224
ILE I 412
GLY I 231
HIS I 232
LEU I 233
 None
 1.26A 1g50B-1yveI:
undetectable		 1g50B-1yveI:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 11 LEU I 224
ILE I 412
GLY I 231
HIS I 232
LEU I 233
 None
 1.25A 1g50C-1yveI:
undetectable		 1g50C-1yveI:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 8 GLY I 255
SER I 518
ASP I 202
THR I 520
 NDP  I 600 (-3.9A)
HIO  I 603 ( 2.6A)
NDP  I 600 (-2.8A)
None
 0.86A 1m4iA-1yveI:
undetectable		 1m4iA-1yveI:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		3 / 3 PHE I 176
TRP I 133
GLU I 170
 None
 0.99A 1mogA-1yveI:
undetectable		 1mogA-1yveI:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 6 LEU I 323
LEU I 479
ILE I 490
GLU I 496
 HIO  I 603 ( 4.4A)
None
None
HIO  I 603 (-2.8A)
 1.04A 1mt1A-1yveI:
undetectable
1mt1F-1yveI:
undetectable		 1mt1A-1yveI:
7.07
1mt1F-1yveI:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 6 ILE I 490
GLU I 496
LEU I 323
LEU I 479
 None
HIO  I 603 (-2.8A)
HIO  I 603 ( 4.4A)
None
 0.89A 1mt1B-1yveI:
undetectable
1mt1C-1yveI:
undetectable		 1mt1B-1yveI:
12.60
1mt1C-1yveI:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 7 LEU I 323
LEU I 479
ILE I 490
GLU I 496
 HIO  I 603 ( 4.4A)
None
None
HIO  I 603 (-2.8A)
 1.06A 1n13I-1yveI:
undetectable
1n13L-1yveI:
undetectable		 1n13I-1yveI:
7.07
1n13L-1yveI:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ND4_A_KANA1300_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 10 ASP I 202
ASP I 315
GLU I 311
ARG I 589
GLU I 319
 NDP  I 600 (-2.8A)
MG  I 602 (-2.7A)
None
NDP  I 600 (-2.8A)
MG  I 601 ( 2.7A)
 1.18A 1nd4A-1yveI:
0.0		 1nd4A-1yveI:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 8 GLY I 231
PHE I 228
ASP I 315
THR I 520
 None
None
MG  I 602 (-2.7A)
None
 0.86A 2aouA-1yveI:
4.2		 2aouA-1yveI:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 7 GLY I 231
PHE I 228
ASP I 315
THR I 520
 None
None
MG  I 602 (-2.7A)
None
 0.96A 2aouB-1yveI:
4.2		 2aouB-1yveI:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 LEU I 224
GLY I 231
SER I 235
GLN I 238
ILE I 412
 None
 1.31A 2e7fB-1yveI:
undetectable		 2e7fB-1yveI:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		3 / 3 ASN I 516
ILE I 436
MET I 433
 None
 0.75A 2h42C-1yveI:
undetectable		 2h42C-1yveI:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 LEU I 224
ILE I 412
GLY I 231
HIS I 232
LEU I 233
 None
 1.25A 2j7xA-1yveI:
undetectable		 2j7xA-1yveI:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 PHE I 504
ASN I 274
GLY I 272
GLN I 264
ILE I 273
 None
 1.25A 2ogyA-1yveI:
undetectable		 2ogyA-1yveI:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 7 LEU I 323
LEU I 479
ILE I 490
GLU I 496
 HIO  I 603 ( 4.4A)
None
None
HIO  I 603 (-2.8A)
 1.01A 2qqdA-1yveI:
undetectable
2qqdE-1yveI:
undetectable		 2qqdA-1yveI:
10.66
2qqdE-1yveI:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 8 VAL I 469
TYR I 388
VAL I 563
VAL I 494
 None
 1.02A 2y05A-1yveI:
4.7
2y05B-1yveI:
5.1		 2y05A-1yveI:
22.66
2y05B-1yveI:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 LEU I 224
ILE I 412
GLY I 231
HIS I 232
LEU I 233
 None
 1.20A 2yjaB-1yveI:
undetectable		 2yjaB-1yveI:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 8 LEU I 298
SER I 300
THR I 303
ALA I 291
 None
 0.99A 3ax9A-1yveI:
undetectable		 3ax9A-1yveI:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 8 LEU I 298
SER I 300
THR I 303
ALA I 291
 None
 1.02A 3ax9B-1yveI:
undetectable		 3ax9B-1yveI:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 5 TYR I 388
ALA I 540
ALA I 465
TYR I 461
 None
 0.96A 3d91A-1yveI:
undetectable		 3d91A-1yveI:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 LEU I 161
GLY I 134
SER I 225
ILE I 159
VAL I 258
 None
NDP  I 600 (-4.0A)
NDP  I 600 (-4.9A)
None
None
 1.03A 3frqB-1yveI:
undetectable		 3frqB-1yveI:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_H_P77H203_1
(PROTEIN S100-A4)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 10 ASP I 282
PHE I  86
PHE I 277
ASP I 289
SER I  90
 None
 1.40A 3m0wE-1yveI:
undetectable
3m0wF-1yveI:
undetectable
3m0wG-1yveI:
0.3
3m0wH-1yveI:
undetectable		 3m0wE-1yveI:
14.46
3m0wF-1yveI:
14.46
3m0wG-1yveI:
14.46
3m0wH-1yveI:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		3 / 3 THR I 520
ASP I 315
GLU I 496
 None
MG  I 602 (-2.7A)
HIO  I 603 (-2.8A)
 0.81A 3qowA-1yveI:
3.3		 3qowA-1yveI:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 HIS I 226
GLY I 227
ASP I 202
ARG I 526
ALA I 521
 NDP  I 600 (-3.9A)
None
NDP  I 600 (-2.8A)
None
HIO  I 603 (-3.4A)
 1.05A 3sueB-1yveI:
undetectable		 3sueB-1yveI:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 LEU I 224
GLY I 231
SER I 235
GLN I 238
ILE I 412
 None
 1.30A 4djeA-1yveI:
undetectable		 4djeA-1yveI:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 LEU I 224
ILE I 412
GLY I 231
HIS I 232
LEU I 233
 None
 1.26A 4j26A-1yveI:
undetectable		 4j26A-1yveI:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 8 PRO I 251
SER I 225
VAL I 249
GLY I 255
 NDP  I 600 (-4.7A)
NDP  I 600 (-4.9A)
None
NDP  I 600 (-3.9A)
 0.90A 4mk4A-1yveI:
2.8		 4mk4A-1yveI:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 11 LEU I 224
ILE I 412
GLY I 231
HIS I 232
LEU I 233
 None
 1.16A 4pxmB-1yveI:
undetectable		 4pxmB-1yveI:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 7 LEU I 501
GLU I 496
SER I 500
VAL I 258
 HIO  I 603 (-4.6A)
HIO  I 603 (-2.8A)
None
None
 1.15A 4tvtA-1yveI:
undetectable		 4tvtA-1yveI:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 10 GLY I 223
ALA I 297
ILE I 128
LEU I 197
LEU I 195
 None
 0.99A 4xj7A-1yveI:
2.6
4xj7B-1yveI:
2.0		 4xj7A-1yveI:
19.77
4xj7B-1yveI:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 10 LEU I 197
LEU I 195
GLY I 223
ALA I 297
ILE I 128
 None
 1.02A 4xj7C-1yveI:
2.5
4xj7D-1yveI:
2.2		 4xj7C-1yveI:
19.77
4xj7D-1yveI:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 ASN I 269
VAL I 268
GLY I 272
ILE I 273
GLN I 136
 None
None
None
None
NDP  I 600 (-4.0A)
 1.02A 4xucA-1yveI:
4.5		 4xucA-1yveI:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		3 / 3 LEU I 523
VAL I 514
ASP I 515
 None
 0.67A 4y8wC-1yveI:
undetectable		 4y8wC-1yveI:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 6 LEU I 144
SER I 295
PRO I 251
GLU I 311
 None
None
NDP  I 600 (-4.7A)
None
 1.30A 5b8iA-1yveI:
undetectable		 5b8iA-1yveI:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 GLY I 272
GLY I 299
GLY I 110
ARG I 259
LEU I 261
 None
None
None
CL  I 604 (-4.3A)
None
 0.99A 5c0oG-1yveI:
4.5		 5c0oG-1yveI:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 11 LEU I 224
ILE I 412
GLY I 231
HIS I 232
LEU I 233
 None
 1.16A 5dxbB-1yveI:
undetectable		 5dxbB-1yveI:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 8 LEU I 118
LEU I 298
ILE I 107
THR I 303
 None
 1.05A 5ljbA-1yveI:
undetectable		 5ljbA-1yveI:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		5 / 12 LEU I 224
ALA I 204
GLN I 140
ARG I 162
GLY I 134
 None
NDP  I 600 (-3.4A)
None
NDP  I 600 (-3.7A)
NDP  I 600 (-4.0A)
 1.18A 5syeB-1yveI:
undetectable		 5syeB-1yveI:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 8 ILE I 364
ALA I 497
LEU I 471
ILE I 360
 None
 0.85A 5uihA-1yveI:
undetectable		 5uihA-1yveI:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE
(Spinacia
oleracea) 		4 / 6 PHE I 122
LEU I 118
ALA I 121
THR I 303
 None
 0.93A 6f88A-1yveI:
undetectable		 6f88A-1yveI:
10.58