SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 LEU A 569
ARG A 512
PHE A 506
GLY A 513
 None
 0.82A 1fapB-1yvlA:
undetectable		 1fapB-1yvlA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 12 LEU A 526
TRP A 495
LEU A 498
ALA A 469
ILE A 558
 None
 1.23A 1g5yB-1yvlA:
undetectable		 1g5yB-1yvlA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 6 LEU A 477
VAL A 457
ILE A 471
ARG A 371
 None
 0.99A 1opjB-1yvlA:
undetectable		 1opjB-1yvlA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.29A 1p6kA-1yvlA:
undetectable		 1p6kA-1yvlA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.29A 1rs6A-1yvlA:
undetectable		 1rs6A-1yvlA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.25A 1zzqA-1yvlA:
undetectable		 1zzqA-1yvlA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.32A 1zzqB-1yvlA:
undetectable		 1zzqB-1yvlA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.31A 1zzuA-1yvlA:
undetectable		 1zzuA-1yvlA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 HIS A  45
SER A  51
ILE A  55
ASP A  49
 None
 1.05A 2xadA-1yvlA:
undetectable		 2xadA-1yvlA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 HIS A  45
SER A  51
ILE A  55
ASP A  49
 None
 1.07A 2xadB-1yvlA:
undetectable		 2xadB-1yvlA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 HIS A  45
SER A  51
ILE A  55
ASP A  49
 None
 1.05A 2xadC-1yvlA:
undetectable		 2xadC-1yvlA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 HIS A  45
SER A  51
ILE A  55
ASP A  49
 None
 1.08A 2xadD-1yvlA:
undetectable		 2xadD-1yvlA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 6 VAL A 146
GLN A 272
PHE A 263
ARG A 147
 None
 1.01A 3bjwF-1yvlA:
undetectable		 3bjwF-1yvlA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 6 LYS A 298
GLN A 285
LEU A 283
GLU A 284
 None
 1.12A 3h5gB-1yvlA:
undetectable
3h5gC-1yvlA:
undetectable		 3h5gB-1yvlA:
7.67
3h5gC-1yvlA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 6 LEU A 308
GLU A 225
ASN A 229
SER A 307
 None
 1.33A 3i9jB-1yvlA:
undetectable		 3i9jB-1yvlA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 LYS A 286
LEU A 206
ASP A 168
ASP A 165
 None
 0.98A 3n2oC-1yvlA:
5.6
3n2oD-1yvlA:
5.4		 3n2oC-1yvlA:
22.99
3n2oD-1yvlA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.30A 3n62A-1yvlA:
undetectable		 3n62A-1yvlA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.30A 3n62B-1yvlA:
undetectable		 3n62B-1yvlA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.27A 3n66B-1yvlA:
undetectable		 3n66B-1yvlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 9 PHE A 341
LEU A 433
VAL A 362
LEU A 409
ILE A 382
 None
 1.19A 3tbgD-1yvlA:
undetectable		 3tbgD-1yvlA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 8 ILE A 558
PHE A 542
SER A 507
GLU A 500
LEU A 519
 None
 1.29A 3ua5A-1yvlA:
undetectable		 3ua5A-1yvlA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 7 TYR A 651
THR A 615
TYR A 634
ARG A 602
 None
 1.20A 3wipA-1yvlA:
2.6
3wipB-1yvlA:
undetectable		 3wipA-1yvlA:
13.60
3wipB-1yvlA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 TYR A 651
THR A 615
TYR A 634
ARG A 602
 None
 1.22A 3wipB-1yvlA:
undetectable
3wipC-1yvlA:
undetectable		 3wipB-1yvlA:
13.60
3wipC-1yvlA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 TYR A 651
THR A 615
TYR A 634
ARG A 602
 None
 1.22A 3wipD-1yvlA:
0.6
3wipE-1yvlA:
0.0		 3wipD-1yvlA:
13.60
3wipE-1yvlA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 7 TYR A 651
THR A 615
TYR A 634
ARG A 602
 None
 1.21A 3wipF-1yvlA:
undetectable
3wipG-1yvlA:
undetectable		 3wipF-1yvlA:
13.60
3wipG-1yvlA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 TYR A 651
THR A 615
TYR A 634
ARG A 602
 None
 1.24A 3wipG-1yvlA:
undetectable
3wipH-1yvlA:
undetectable		 3wipG-1yvlA:
13.60
3wipH-1yvlA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 ARG A 602
TYR A 651
THR A 615
TYR A 634
 None
 1.24A 3wipF-1yvlA:
undetectable
3wipJ-1yvlA:
2.7		 3wipF-1yvlA:
13.60
3wipJ-1yvlA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 8 TRP A 573
LEU A 562
ILE A 561
GLY A 580
ILE A 578
 None
 1.31A 3wxoA-1yvlA:
1.3		 3wxoA-1yvlA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 12 GLY A 467
ALA A 469
ARG A 378
ILE A 458
VAL A 334
 None
 1.27A 4azsA-1yvlA:
undetectable		 4azsA-1yvlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		3 / 3 ASN A 520
LEU A 590
PHE A 581
 None
 0.81A 4dajB-1yvlA:
0.3		 4dajB-1yvlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 7 PHE A 581
ASN A 515
GLY A 513
ILE A 565
PHE A 603
 None
 1.19A 4ejjA-1yvlA:
undetectable		 4ejjA-1yvlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 7 PHE A 581
ASN A 515
GLY A 513
THR A 510
ILE A 565
 None
 1.25A 4ejjA-1yvlA:
undetectable		 4ejjA-1yvlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 7 PHE A 581
ASN A 515
GLY A 513
ILE A 565
 None
 0.78A 4ejjD-1yvlA:
undetectable		 4ejjD-1yvlA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 12 LEU A 464
CYH A 543
VAL A 334
PHE A 487
THR A 427
 None
 1.31A 4iaqA-1yvlA:
undetectable		 4iaqA-1yvlA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		3 / 3 ARG A 113
LYS A 114
LYS A 110
 None
 1.28A 4k50A-1yvlA:
undetectable		 4k50A-1yvlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		3 / 3 ARG A 113
LYS A 114
LYS A 110
 None
 1.32A 4k50E-1yvlA:
undetectable		 4k50E-1yvlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		3 / 3 ARG A 113
LYS A 114
LYS A 110
 None
 1.33A 4k50I-1yvlA:
undetectable		 4k50I-1yvlA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 7 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.33A 4kcnB-1yvlA:
undetectable		 4kcnB-1yvlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 12 PHE A 599
ILE A 671
THR A 643
TYR A 680
LEU A 601
 None
 1.50A 4qztC-1yvlA:
undetectable		 4qztC-1yvlA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 5 SER A 470
GLY A 467
GLU A 428
PHE A 487
 None
 1.07A 4r82A-1yvlA:
undetectable
4r82B-1yvlA:
undetectable		 4r82A-1yvlA:
15.82
4r82B-1yvlA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		3 / 3 TYR A 106
ARG A 113
LYS A 110
 None
 1.27A 4wq5B-1yvlA:
undetectable		 4wq5B-1yvlA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 12 GLU A 282
LEU A 277
GLN A 275
ILE A 294
VAL A 213
 None
 1.07A 5dpdA-1yvlA:
2.1		 5dpdA-1yvlA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		3 / 3 ASN A 520
LEU A 590
PHE A 581
 None
 0.73A 5dsgA-1yvlA:
3.6		 5dsgA-1yvlA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 8 ARG A  31
LEU A  34
LEU A  38
LEU A  90
LEU A  64
 None
 1.49A 5jqbA-1yvlA:
undetectable
5jqbB-1yvlA:
undetectable		 5jqbA-1yvlA:
17.53
5jqbB-1yvlA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.26A 5vunA-1yvlA:
undetectable		 5vunA-1yvlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.31A 5vunB-1yvlA:
undetectable		 5vunB-1yvlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.30A 5vuoB-1yvlA:
undetectable		 5vuoB-1yvlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 12 LEU A 562
ILE A 565
LEU A 527
GLY A 580
LEU A 514
 None
 0.90A 6a7pA-1yvlA:
undetectable		 6a7pA-1yvlA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 8 GLN A  95
PHE A  94
ASN A  89
ASP A  92
 None
 1.28A 6auuB-1yvlA:
undetectable		 6auuB-1yvlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		4 / 6 ILE A 160
LEU A 283
VAL A 213
ARG A 210
 None
 1.13A 6f6jA-1yvlA:
undetectable		 6f6jA-1yvlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		3 / 3 TYR A 170
ASP A 168
GLN A 167
 None
 0.81A 6g1pA-1yvlA:
undetectable		 6g1pA-1yvlA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA
(Homo
sapiens) 		5 / 12 ASN A 483
PRO A 454
ILE A 471
VAL A 456
PHE A 487
 None
 1.22A 6j21A-1yvlA:
1.5		 6j21A-1yvlA:
18.99