SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yvp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		5 / 9 ALA A 231
LEU A 253
LEU A 258
ILE A 245
HIS A 246
 None
 1.41A 1ereA-1yvpA:
undetectable		 1ereA-1yvpA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 5 SER A 100
SER A 103
PHE A 128
VAL A  74
 None
 1.34A 1oipA-1yvpA:
2.9		 1oipA-1yvpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		5 / 10 ALA A 231
LEU A 253
LEU A 258
ILE A 245
HIS A 246
 None
 1.40A 1qkuA-1yvpA:
undetectable		 1qkuA-1yvpA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		5 / 10 ALA A 231
LEU A 253
LEU A 258
ILE A 245
HIS A 246
 None
 1.41A 1qkuB-1yvpA:
undetectable		 1qkuB-1yvpA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		5 / 10 ALA A 231
LEU A 253
LEU A 258
ILE A 245
HIS A 246
 None
 1.41A 1qkuC-1yvpA:
undetectable		 1qkuC-1yvpA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 6 ARG A 234
ASP A 160
ASN A 163
GLU A 230
 None
 1.32A 1rjdC-1yvpA:
undetectable		 1rjdC-1yvpA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		5 / 12 PHE A 467
GLY A 521
ALA A 526
VAL A 385
ALA A 396
 None
 1.09A 1sg9C-1yvpA:
2.4		 1sg9C-1yvpA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 8 SER A 360
LEU A 527
LEU A 386
MET A 399
 None
 0.96A 1wrlC-1yvpA:
undetectable
1wrlD-1yvpA:
undetectable		 1wrlC-1yvpA:
9.75
1wrlD-1yvpA:
9.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		5 / 5 TYR A  47
SER A 378
SER A 380
THR A 445
ASN A 473
 None
MG  A1001 ( 2.2A)
MG  A1001 ( 2.1A)
MG  A1001 ( 2.9A)
ACT  A2001 (-3.1A)
 0.00A 1yvpA-1yvpA:
67.3		 1yvpA-1yvpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		6 / 6 TYR A  47
SER A 378
ALA A 379
SER A 380
THR A 445
ASN A 473
 None
MG  A1001 ( 2.2A)
ACT  A2001 (-4.0A)
MG  A1001 ( 2.1A)
MG  A1001 ( 2.9A)
ACT  A2001 (-3.1A)
 0.27A 1yvpB-1yvpA:
58.4		 1yvpB-1yvpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		5 / 11 VAL A 304
ILE A 349
LEU A 285
LEU A 278
LEU A 282
 None
None
None
A  G  10 ( 4.3A)
None
 1.23A 2a15A-1yvpA:
undetectable		 2a15A-1yvpA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 5 LEU A 195
ASN A 192
VAL A 225
ALA A 161
 None
 1.19A 2cizA-1yvpA:
0.0		 2cizA-1yvpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 6 ARG A  32
SER A  41
GLY A  44
THR A  45
 None
 1.25A 2f7fA-1yvpA:
2.6		 2f7fA-1yvpA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		7 / 7 TYR A  47
SER A 378
ALA A 379
SER A 380
SER A 444
THR A 445
ASN A 473
 None
MG  A1001 ( 2.2A)
ACT  A2001 (-4.0A)
MG  A1001 ( 2.1A)
ACT  A2001 (-4.3A)
MG  A1001 ( 2.9A)
ACT  A2001 (-3.1A)
 0.30A 2i91A-1yvpA:
62.1		 2i91A-1yvpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		7 / 7 TYR A  47
SER A 378
ALA A 379
SER A 380
SER A 444
THR A 445
ASN A 473
 None
MG  A1001 ( 2.2A)
ACT  A2001 (-4.0A)
MG  A1001 ( 2.1A)
ACT  A2001 (-4.3A)
MG  A1001 ( 2.9A)
ACT  A2001 (-3.1A)
 0.30A 2i91B-1yvpA:
55.4		 2i91B-1yvpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 5 LEU A 278
ALA A 356
ILE A 324
SER A 360
 A  G  10 ( 4.3A)
None
None
None
 1.16A 2othA-1yvpA:
undetectable		 2othA-1yvpA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		3 / 3 TRP A 144
GLN A 101
TRP A 155
 C  C   8 ( 4.1A)
None
None
 1.12A 2vqyA-1yvpA:
undetectable		 2vqyA-1yvpA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 4 TYR A 156
LEU A 195
LEU A 164
HIS A 179
 None
 1.24A 2x7hB-1yvpA:
2.8		 2x7hB-1yvpA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 5 VAL A  73
VAL A  74
GLN A  82
PHE A  36
 None
 1.08A 3bjwH-1yvpA:
undetectable		 3bjwH-1yvpA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 6 VAL A  73
VAL A  74
GLN A  82
PHE A  36
 None
 1.02A 3bjwF-1yvpA:
undetectable		 3bjwF-1yvpA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 5 VAL A  73
VAL A  74
GLN A  82
PHE A  36
 None
 1.14A 3bjwB-1yvpA:
undetectable		 3bjwB-1yvpA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 6 PHE A 361
TYR A 358
VAL A 395
PHE A 357
 None
 1.38A 3ltwA-1yvpA:
undetectable		 3ltwA-1yvpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 7 LEU A 341
ASP A 291
THR A 289
ALA A 290
 None
 1.23A 3mbgA-1yvpA:
undetectable
3mbgB-1yvpA:
undetectable		 3mbgA-1yvpA:
13.83
3mbgB-1yvpA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		3 / 3 LYS A  88
ARG A 283
LYS A 333
 None
C  G   7 ( 3.5A)
None
 1.20A 3okxA-1yvpA:
undetectable		 3okxA-1yvpA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 5 GLY A 525
ASP A 523
ARG A  34
GLN A  82
 None
 1.47A 3qx3A-1yvpA:
2.2		 3qx3A-1yvpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		5 / 12 ASP A 376
SER A 378
THR A 441
ASN A 382
TYR A  47
 MG  A1001 ( 4.5A)
MG  A1001 ( 2.2A)
None
None
None
 1.49A 3rzeA-1yvpA:
undetectable		 3rzeA-1yvpA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 5 ILE A 508
VAL A 498
PHE A 371
HIS A 478
 None
 1.33A 4rzvA-1yvpA:
undetectable		 4rzvA-1yvpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 7 ASP A 523
ARG A  85
GLY A  84
GLU A  83
 None
None
C  G   8 ( 4.5A)
None
 0.87A 5bs8A-1yvpA:
undetectable
5bs8C-1yvpA:
undetectable
5bs8D-1yvpA:
2.3		 5bs8A-1yvpA:
22.43
5bs8C-1yvpA:
22.43
5bs8D-1yvpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 7 ASP A 523
ARG A  85
GLY A  84
GLU A  83
 None
None
C  G   8 ( 4.5A)
None
 0.90A 5btaA-1yvpA:
undetectable
5btaC-1yvpA:
undetectable
5btaD-1yvpA:
2.5		 5btaA-1yvpA:
22.26
5btaC-1yvpA:
22.26
5btaD-1yvpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 7 ASP A 523
ARG A  85
GLY A  84
GLU A  83
 None
None
C  G   8 ( 4.5A)
None
 0.90A 5btfA-1yvpA:
undetectable
5btfB-1yvpA:
2.2
5btfC-1yvpA:
undetectable		 5btfA-1yvpA:
22.26
5btfB-1yvpA:
19.84
5btfC-1yvpA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 6 ASP A 523
ARG A  85
GLY A  84
GLU A  83
 None
None
C  G   8 ( 4.5A)
None
 0.99A 5cdqA-1yvpA:
2.2
5cdqC-1yvpA:
2.0
5cdqD-1yvpA:
2.1		 5cdqA-1yvpA:
21.80
5cdqC-1yvpA:
21.80
5cdqD-1yvpA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		5 / 10 ALA A 461
ILE A 497
ILE A 530
VAL A 403
PHE A 371
 None
 1.21A 5nukA-1yvpA:
undetectable		 5nukA-1yvpA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		6 / 12 ILE A 375
LEU A 430
VAL A 433
ILE A 424
MET A 437
LEU A 527
 None
 1.46A 5ycnA-1yvpA:
undetectable		 5ycnA-1yvpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN
(Xenopus
laevis) 		4 / 5 GLY A 525
ASP A 523
ARG A  34
GLN A  82
 None
 1.31A 5zrfB-1yvpA:
2.1		 5zrfB-1yvpA:
20.79