SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OCU_A_TYLA3001_1 (LACTOTRANSFERRIN)	1yw0	TRYPTOPHAN 2,3-DIOXYGENASE (Xanthomonas campestris)	3 / 3	LEU A 173 TYR A 169 GLY A 139	None	0.61A	2ocuA-1yw0A: undetectable	2ocuA-1yw0A: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JUS_B_ECLB600_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	1yw0	TRYPTOPHAN 2,3-DIOXYGENASE (Xanthomonas campestris)	4 / 8	LEU A 108 THR A 107 THR A 57 ILE A 53	None	0.70A	3jusB-1yw0A: undetectable	3jusB-1yw0A: 18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CLA_A_CLMA221_0 (TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE)	1yw0	TRYPTOPHAN 2,3-DIOXYGENASE (Xanthomonas campestris)	5 / 11	LEU A 226 PHE A 272 SER A 91 VAL A 162 ILE A 134	None	1.44A	4claA-1yw0A: undetectable	4claA-1yw0A: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X19_C_CHDC304_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	1yw0	TRYPTOPHAN 2,3-DIOXYGENASE (Xanthomonas campestris)	4 / 5	LEU A 129 PHE A 149 LEU A 159 PHE A 136	None	0.99A	5x19C-1yw0A: 4.6 5x19J-1yw0A: undetectable	5x19C-1yw0A: 22.04 5x19J-1yw0A: 12.50

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OCU_A_TYLA3001_1","LACTOTRANSFERRIN","1yw0","TRYPTOPHAN 2,3-DIOXYGENASE","Xanthomonas campestris",3,"LEU A 173;TYR A 169;GLY A 139","None","0.61A","2ocuA-1yw0A:undetectable","2ocuA-1yw0A:21.88"],["3JUS_B_ECLB600_1","LANOSTEROL 14-ALPHA DEMETHYLASE","1yw0","TRYPTOPHAN 2,3-DIOXYGENASE","Xanthomonas campestris",4,"LEU A 108;THR A 107;THR A  57;ILE A  53","None","0.70A","3jusB-1yw0A:undetectable","3jusB-1yw0A:18.22"],["4CLA_A_CLMA221_0","TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE","1yw0","TRYPTOPHAN 2,3-DIOXYGENASE","Xanthomonas campestris",5,"LEU A 226;PHE A 272;SER A  91;VAL A 162;ILE A 134","None","1.44A","4claA-1yw0A:undetectable","4claA-1yw0A:21.00"],["5X19_C_CHDC304_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","1yw0","TRYPTOPHAN 2,3-DIOXYGENASE","Xanthomonas campestris",4,"LEU A 129;PHE A 149;LEU A 159;PHE A 136","None","0.99A","5x19C-1yw0A:4.6;5x19J-1yw0A:undetectable","5x19C-1yw0A:22.04;5x19J-1yw0A:12.50"]]