SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 12 TYR A 149
ILE A 234
VAL A 251
ASP A 250
HIS A 145
 FMN  A2606 (-4.0A)
None
None
None
FMN  A2606 (-4.2A)
 1.32A 1nbhC-1yw1A:
undetectable		 1nbhC-1yw1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 8 ALA A 383
ILE A 374
ILE A   7
ILE A 387
PRO A 273
 None
 1.37A 1sh9A-1yw1A:
undetectable		 1sh9A-1yw1A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		3 / 3 ASP A 391
ILE A 387
VAL A 400
 None
 0.70A 2avvD-1yw1A:
undetectable		 2avvD-1yw1A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 12 GLY A 118
GLY A 420
GLN A 209
THR A 421
GLU A 424
 None
 1.32A 2azxA-1yw1A:
undetectable		 2azxA-1yw1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 12 GLY A 118
GLY A 420
GLN A 209
THR A 421
GLU A 424
 None
 1.29A 2azxB-1yw1A:
undetectable		 2azxB-1yw1A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		4 / 6 ASN A 230
GLN A 153
THR A  98
PRO A 103
 None
 1.30A 2ez7A-1yw1A:
undetectable		 2ez7A-1yw1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		3 / 3 ASN A 124
TYR A 149
SER A  97
 FMN  A2606 ( 4.5A)
FMN  A2606 (-4.0A)
None
 0.92A 2gvcB-1yw1A:
undetectable		 2gvcB-1yw1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		3 / 3 ASN A 124
TYR A 149
SER A  97
 FMN  A2606 ( 4.5A)
FMN  A2606 (-4.0A)
None
 0.91A 2gvcE-1yw1A:
undetectable		 2gvcE-1yw1A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		3 / 3 ASP A 416
TYR A 417
LYS A  88
 None
 0.61A 2othA-1yw1A:
undetectable		 2othA-1yw1A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		4 / 8 PHE A  38
ILE A  13
GLY A 389
ILE A 387
 None
 0.94A 2qwxA-1yw1A:
undetectable
2qwxB-1yw1A:
undetectable		 2qwxA-1yw1A:
19.64
2qwxB-1yw1A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 12 ILE A 374
LEU A 407
ILE A 404
VAL A 275
PRO A 273
 None
 1.15A 3a51D-1yw1A:
undetectable		 3a51D-1yw1A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 11 LEU A 156
ALA A 231
VAL A 159
LEU A 110
PHE A 226
 None
 1.30A 3bszE-1yw1A:
undetectable		 3bszE-1yw1A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 9 THR A 395
VAL A 370
SER A 372
ILE A 392
GLY A 389
 None
 1.25A 3cv9A-1yw1A:
undetectable		 3cv9A-1yw1A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 12 ILE A 404
ALA A  46
PHE A   9
SER A 272
ILE A 271
 None
 1.06A 3ia4D-1yw1A:
undetectable		 3ia4D-1yw1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 12 PHE A 215
ILE A 267
ALA A 383
ASP A 384
LEU A 426
 None
 1.20A 3s79A-1yw1A:
undetectable		 3s79A-1yw1A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		4 / 6 LEU A 422
ALA A  43
THR A  87
LEU A  80
 None
 1.00A 3t3zB-1yw1A:
undetectable		 3t3zB-1yw1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		4 / 6 LEU A 422
ALA A  43
THR A  87
LEU A  80
 None
 0.99A 3t3zD-1yw1A:
undetectable		 3t3zD-1yw1A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		3 / 3 ASP A 114
GLU A 211
GLY A 210
 None
 0.69A 3w9tA-1yw1A:
undetectable		 3w9tA-1yw1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 7 TRP A 377
VAL A 370
PHE A 399
VAL A 388
PHE A 386
 None
 1.44A 3zjqA-1yw1A:
0.0		 3zjqA-1yw1A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 7 TRP A 377
VAL A 370
PHE A 399
VAL A 388
PHE A 386
 None
 1.45A 3zjqB-1yw1A:
0.0		 3zjqB-1yw1A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		4 / 7 PHE A 386
PHE A   9
PHE A 363
LEU A 407
 None
 0.99A 4ejgA-1yw1A:
undetectable		 4ejgA-1yw1A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 7 ILE A 374
ASP A 384
GLY A 385
PHE A   9
TYR A 248
 None
 1.49A 4iqqA-1yw1A:
undetectable		 4iqqA-1yw1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 12 GLY A 122
GLY A  94
LEU A 113
ASN A 124
LEU A 422
 None
None
None
FMN  A2606 ( 4.5A)
None
 1.31A 4x61A-1yw1A:
undetectable		 4x61A-1yw1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		4 / 5 SER A 207
GLU A 424
SER A  52
GLN A   8
 None
 1.47A 5fhrB-1yw1A:
undetectable		 5fhrB-1yw1A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		4 / 6 ILE A 234
PHE A 235
PHE A 226
THR A  98
 None
FMN  A2606 (-4.2A)
None
None
 1.30A 5g08A-1yw1A:
undetectable		 5g08A-1yw1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 12 PHE A 215
ILE A 267
ALA A 383
ASP A 384
LEU A 426
 None
 1.20A 5jkvA-1yw1A:
undetectable		 5jkvA-1yw1A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 12 VAL A 214
ASP A 232
LEU A 189
ARG A 423
GLY A 210
 None
 1.24A 5m50E-1yw1A:
undetectable		 5m50E-1yw1A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1yw1 PROTEIN YTNJ
(Bacillus
subtilis) 		5 / 10 ILE A 374
ASP A 384
GLY A 385
PHE A   9
TYR A 248
 None
 1.43A 5x66D-1yw1A:
undetectable		 5x66D-1yw1A:
20.77