SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_2
(DIHYDROFOLATE
REDUCTASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 4 TYR A 146
ARG A 142
VAL A  86
THR A 202
 None
 1.36A 1dlsA-1yw4A:
0.3		 1dlsA-1yw4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 8 SER A 155
ALA A 187
PHE A 157
ILE A 185
 None
 1.08A 1gm7A-1yw4A:
undetectable
1gm7B-1yw4A:
undetectable		 1gm7A-1yw4A:
21.25
1gm7B-1yw4A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 7 THR A  71
LEU A  78
GLY A  76
LEU A  23
 None
 1.03A 1gtiD-1yw4A:
undetectable		 1gtiD-1yw4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 7 THR A  71
LEU A  78
GLY A  76
LEU A  23
 None
 1.01A 1gtiE-1yw4A:
undetectable		 1gtiE-1yw4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		3 / 3 ARG A 170
ASP A  47
ASN A 242
 None
 0.68A 1nbhA-1yw4A:
undetectable		 1nbhA-1yw4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		3 / 3 ARG A 170
ASP A  47
ASN A 242
 None
 0.65A 1nbhD-1yw4A:
undetectable		 1nbhD-1yw4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 131
MET A  87
LEU A  50
GLU A 129
 None
 1.20A 2kuhA-1yw4A:
undetectable		 2kuhA-1yw4A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 7 HIS A 172
LEU A 330
LEU A 190
LEU A 257
 None
 0.88A 3bgdB-1yw4A:
undetectable		 3bgdB-1yw4A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  86
LEU A 148
SER A 241
VAL A  66
ILE A 232
 None
 1.05A 3frqA-1yw4A:
undetectable		 3frqA-1yw4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 12 VAL A  86
LEU A 148
SER A 241
VAL A  66
ILE A 232
 None
 1.03A 3frqB-1yw4A:
undetectable		 3frqB-1yw4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 10 LEU A  85
GLY A  35
ASP A  67
GLY A  54
VAL A  55
 None
 0.96A 3oxwA-1yw4A:
undetectable		 3oxwA-1yw4A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 10 LEU A  85
GLY A  35
ASP A  67
GLY A  54
VAL A  55
 None
 0.98A 3oxwC-1yw4A:
undetectable		 3oxwC-1yw4A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 177
PHE A 211
ALA A 210
LEU A 166
 None
 0.98A 3t3zA-1yw4A:
undetectable		 3t3zA-1yw4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 177
PHE A 211
ALA A 210
LEU A 166
 None
 0.97A 3t3zB-1yw4A:
undetectable		 3t3zB-1yw4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 6 LEU A 177
PHE A 211
ALA A 210
LEU A 166
 None
 0.97A 3t3zD-1yw4A:
undetectable		 3t3zD-1yw4A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 12 GLU A 214
ASN A 281
PHE A 310
GLY A 216
ARG A  99
 ZN  A 501 ( 4.5A)
None
None
None
ZN  A 501 ( 4.3A)
 1.43A 4djfA-1yw4A:
undetectable		 4djfA-1yw4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 11 ASN A 106
HIS A 145
VAL A  55
LEU A 128
ALA A 132
 None
 1.33A 4ygfA-1yw4A:
undetectable		 4ygfA-1yw4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 11 ASN A 106
HIS A 145
VAL A  55
LEU A 128
ALA A 132
 None
 1.31A 4ygfC-1yw4A:
undetectable		 4ygfC-1yw4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 12 ASN A 106
HIS A 145
VAL A  55
LEU A 128
ALA A 132
 None
 1.27A 4yhaA-1yw4A:
undetectable		 4yhaA-1yw4A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 7 PHE A 211
ALA A 161
HIS A 191
PRO A 164
 None
 1.12A 5dzkD-1yw4A:
undetectable
5dzkR-1yw4A:
undetectable		 5dzkD-1yw4A:
23.10
5dzkR-1yw4A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		4 / 6 GLU A  38
GLY A  41
ARG A  30
ARG A  44
 None
 1.44A 5jcnB-1yw4A:
undetectable		 5jcnB-1yw4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 12 ALA A  11
GLY A  35
GLU A 127
GLU A 129
LEU A 131
 None
 1.27A 5nwuA-1yw4A:
undetectable		 5nwuA-1yw4A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE
(Chromobacterium
violaceum) 		5 / 12 LEU A  39
ASP A  47
VAL A  49
LEU A 144
VAL A  86
 None
 1.05A 6dgxB-1yw4A:
undetectable		 6dgxB-1yw4A:
11.73