SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE
(Candida
albicans) 		4 / 6 LEU A  74
GLY A 169
SER A  80
ILE A  92
 None
 0.93A 1yajF-1yw5A:
undetectable		 1yajF-1yw5A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE
(Candida
albicans) 		3 / 3 GLY A  66
ASP A  65
SER A 140
 None
 0.74A 2qhfA-1yw5A:
undetectable		 2qhfA-1yw5A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE
(Candida
albicans) 		5 / 12 LEU A 107
LEU A 103
LEU A 120
LEU A 117
GLY A 113
 None
 1.04A 4pxmA-1yw5A:
undetectable		 4pxmA-1yw5A:
21.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TNS_A_REAA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1)		 1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE
(Candida
albicans) 		7 / 9 HIS A  72
LYS A  76
MET A 144
GLN A 145
PHE A 148
SER A 168
HIS A 171
 None
 0.28A 4tnsA-1yw5A:
22.7		 4tnsA-1yw5A:
38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE
(Candida
albicans) 		3 / 3 ALA A 151
ASN A 154
LEU A 155
 None
 0.34A 5i1nC-1yw5A:
undetectable		 5i1nC-1yw5A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE
(Candida
albicans) 		3 / 3 ALA A 151
ASN A 154
LEU A 155
 None
 0.37A 5i1pA-1yw5A:
undetectable		 5i1pA-1yw5A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE
(Candida
albicans) 		3 / 3 ALA A 151
ASN A 154
LEU A 155
 None
 0.49A 5i1pD-1yw5A:
undetectable		 5i1pD-1yw5A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 1yw5 PEPTIDYL PROLYL
CIS/TRANS ISOMERASE
(Candida
albicans) 		5 / 9 VAL A  70
LEU A 136
ILE A 164
LEU A 103
ALA A 152
 None
 1.32A 5og9A-1yw5A:
undetectable		 5og9A-1yw5A:
17.87