SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 5 HIS A 147
LEU A  91
LEU A  82
GLY A  86
None
1.07A 1a4lB-1yw6A:
undetectable
1a4lB-1yw6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
3 / 3 TRP A 142
VAL A  47
TRP A  79
None
1.07A 1c4dA-1yw6A:
undetectable
1c4dB-1yw6A:
undetectable
1c4dA-1yw6A:
3.59
1c4dB-1yw6A:
3.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 8 PHE A 106
THR A 193
HIS A 147
HIS A  53
None
0.99A 1ei6D-1yw6A:
undetectable
1ei6D-1yw6A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 10 LEU A  82
ALA A 204
VAL A  33
LEU A 125
ASP A 134
None
1.32A 1rlbE-1yw6A:
1.8
1rlbE-1yw6A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 LEU A 112
PHE A 106
GLY A 107
GLY A 108
ALA A 122
None
0.97A 1v2xA-1yw6A:
undetectable
1v2xA-1yw6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 ILE A  48
LEU A 144
THR A 148
LEU A 211
None
0.95A 1v55A-1yw6A:
undetectable
1v55J-1yw6A:
undetectable
1v55A-1yw6A:
20.62
1v55J-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.90A 1v55P-1yw6A:
undetectable
1v55W-1yw6A:
undetectable
1v55P-1yw6A:
20.54
1v55W-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.89A 2dysC-1yw6A:
undetectable
2dysJ-1yw6A:
undetectable
2dysC-1yw6A:
20.54
2dysJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.86A 2dysP-1yw6A:
undetectable
2dysW-1yw6A:
undetectable
2dysP-1yw6A:
20.54
2dysW-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.88A 2eijP-1yw6A:
undetectable
2eijW-1yw6A:
undetectable
2eijP-1yw6A:
20.54
2eijW-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 8 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.88A 2eilP-1yw6A:
undetectable
2eilW-1yw6A:
undetectable
2eilP-1yw6A:
20.54
2eilW-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
6 / 12 ARG A 250
LEU A 184
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
1.31A 2ienA-1yw6A:
undetectable
2ienA-1yw6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
3 / 3 LEU A 273
LEU A 318
MET A 317
None
0.73A 2itzA-1yw6A:
undetectable
2itzA-1yw6A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 LEU A  82
GLY A  32
GLY A  51
ILE A  52
VAL A  47
None
0.91A 2nnkB-1yw6A:
undetectable
2nnkB-1yw6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
3 / 3 ASP A 134
THR A  37
PRO A  38
None
0.58A 2pynB-1yw6A:
undetectable
2pynB-1yw6A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 ARG A 250
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
0.85A 2q5kB-1yw6A:
undetectable
2q5kB-1yw6A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
3 / 3 ASP A 134
THR A  37
PRO A  38
None
0.66A 2q64B-1yw6A:
undetectable
2q64B-1yw6A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
3 / 3 ASP A 134
THR A  37
PRO A  38
None
0.58A 2qakB-1yw6A:
undetectable
2qakB-1yw6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 8 LEU A  46
ILE A  48
LEU A 144
LEU A 235
None
0.81A 2xfhA-1yw6A:
undetectable
2xfhA-1yw6A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 6 LEU A 307
ARG A 151
ILE A 150
LEU A  91
None
0.90A 2xkwB-1yw6A:
undetectable
2xkwB-1yw6A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 VAL A 227
THR A 208
VAL A 160
PHE A 275
ASN A 274
None
1.32A 2y00B-1yw6A:
undetectable
2y00B-1yw6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 6 LEU A  36
ILE A  70
MET A   1
PRO A   0
None
1.12A 2ygoA-1yw6A:
undetectable
2ygoA-1yw6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.85A 2zxwC-1yw6A:
undetectable
2zxwJ-1yw6A:
undetectable
2zxwC-1yw6A:
20.54
2zxwJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 6 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.87A 2zxwP-1yw6A:
undetectable
2zxwW-1yw6A:
undetectable
2zxwP-1yw6A:
20.54
2zxwW-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 6 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.90A 3abkP-1yw6A:
undetectable
3abkW-1yw6A:
undetectable
3abkP-1yw6A:
20.54
3abkW-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 6 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.87A 3ag1C-1yw6A:
undetectable
3ag1J-1yw6A:
undetectable
3ag1C-1yw6A:
20.54
3ag1J-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
6 / 12 ARG A 250
LEU A 184
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
1.28A 3bvbA-1yw6A:
undetectable
3bvbA-1yw6A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 ARG A 250
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
1.02A 3d1zB-1yw6A:
undetectable
3d1zB-1yw6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 8 LEU A 184
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
1.12A 3ekpA-1yw6A:
undetectable
3ekpA-1yw6A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 ARG A 250
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
1.06A 3gguA-1yw6A:
undetectable
3gguA-1yw6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 GLY A 107
PHE A 197
CYH A 128
PHE A 202
None
1.08A 3ko0D-1yw6A:
undetectable
3ko0E-1yw6A:
undetectable
3ko0D-1yw6A:
16.00
3ko0E-1yw6A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
6 / 11 ARG A 250
LEU A 184
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
1.36A 3nu3B-1yw6A:
undetectable
3nu3B-1yw6A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
6 / 12 ARG A 250
LEU A 184
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
1.34A 3s54A-1yw6A:
undetectable
3s54A-1yw6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 8 GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
0.67A 3so9A-1yw6A:
undetectable
3so9A-1yw6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 7 ARG A 250
LEU A 184
ALA A 179
GLY A 242
ILE A 243
None
1.47A 3spkB-1yw6A:
undetectable
3spkB-1yw6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
3 / 3 ASP A 134
THR A  37
PRO A  38
None
0.67A 3tkgD-1yw6A:
undetectable
3tkgD-1yw6A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 10 GLY A 180
ALA A 179
GLY A 242
ILE A 243
LEU A 173
None
0.74A 3ttpA-1yw6A:
undetectable
3ttpA-1yw6A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 10 GLY A 180
ALA A 179
GLY A 242
ILE A 243
LEU A 173
None
0.75A 3ttpB-1yw6A:
undetectable
3ttpB-1yw6A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 9 ARG A 250
ALA A 179
GLY A 242
ILE A 243
LEU A 173
None
1.16A 3u7sB-1yw6A:
undetectable
3u7sB-1yw6A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 9 GLY A 180
ALA A 179
GLY A 242
ILE A 243
LEU A 173
None
0.78A 3u7sB-1yw6A:
undetectable
3u7sB-1yw6A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 6 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.98A 3wg7P-1yw6A:
undetectable
3wg7W-1yw6A:
undetectable
3wg7P-1yw6A:
20.54
3wg7W-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 PHE A 186
ARG A 250
ALA A 179
GLU A 170
THR A 174
None
1.29A 4fiaA-1yw6A:
undetectable
4fiaA-1yw6A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 PHE A 186
ARG A 250
ALA A 179
GLU A 170
THR A 174
None
1.29A 4fiaA-1yw6A:
undetectable
4fiaA-1yw6A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 11 HIS A 147
ASP A 101
ARG A 123
GLU A  56
GLU A 118
None
1.31A 4gkiC-1yw6A:
0.0
4gkiD-1yw6A:
0.0
4gkiC-1yw6A:
22.45
4gkiD-1yw6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 8 HIS A  53
PRO A 306
ALA A  90
ASP A 101
None
1.06A 4k0bB-1yw6A:
undetectable
4k0bB-1yw6A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 10 ARG A 121
MET A 102
GLU A 115
PHE A 106
LEU A 125
None
1.45A 4la0A-1yw6A:
undetectable
4la0A-1yw6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 PHE A   4
ASP A   2
PRO A  14
ILE A  70
None
1.05A 4pcuA-1yw6A:
1.6
4pcuA-1yw6A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 11 MET A  62
LEU A  63
LEU A 209
LEU A 146
LEU A 176
None
0.98A 4zowA-1yw6A:
undetectable
4zowA-1yw6A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
3 / 3 THR A 193
HIS A 155
LEU A 302
None
0.69A 5axdA-1yw6A:
undetectable
5axdA-1yw6A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
3 / 3 THR A 193
HIS A 155
LEU A 302
None
0.70A 5axdC-1yw6A:
undetectable
5axdC-1yw6A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 ILE A  48
LEU A 144
THR A 148
LEU A 211
None
0.94A 5b1aA-1yw6A:
undetectable
5b1aJ-1yw6A:
undetectable
5b1aA-1yw6A:
20.62
5b1aJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 ILE A  48
LEU A 144
THR A 148
LEU A 211
None
0.96A 5b1bA-1yw6A:
0.0
5b1bJ-1yw6A:
undetectable
5b1bA-1yw6A:
20.62
5b1bJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
6 / 12 ARG A 250
LEU A 184
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
1.37A 5e5jB-1yw6A:
undetectable
5e5jB-1yw6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 ASP A 271
ALA A 269
GLN A 256
GLY A 315
THR A 258
None
1.33A 5hfjC-1yw6A:
undetectable
5hfjC-1yw6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 4 CYH A 207
LEU A 209
LEU A 176
ALA A 179
None
1.05A 5hpuA-1yw6A:
undetectable
5hpuB-1yw6A:
undetectable
5hpuA-1yw6A:
5.13
5hpuB-1yw6A:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.89A 5iy5C-1yw6A:
undetectable
5iy5J-1yw6A:
undetectable
5iy5C-1yw6A:
20.36
5iy5J-1yw6A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 ILE A  48
LEU A 144
THR A 148
LEU A 211
None
0.97A 5iy5A-1yw6A:
0.0
5iy5J-1yw6A:
undetectable
5iy5A-1yw6A:
20.62
5iy5J-1yw6A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 5 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.84A 5iy5P-1yw6A:
undetectable
5iy5W-1yw6A:
undetectable
5iy5P-1yw6A:
20.36
5iy5W-1yw6A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
0.66A 5kqyB-1yw6A:
undetectable
5kqyB-1yw6A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 8 GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
0.66A 5kr1B-1yw6A:
undetectable
5kr1B-1yw6A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 8 THR A 174
CYH A 207
TRP A 168
LEU A 184
None
1.27A 5kxiA-1yw6A:
0.0
5kxiB-1yw6A:
undetectable
5kxiA-1yw6A:
21.24
5kxiB-1yw6A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 8 THR A 174
CYH A 207
TRP A 168
LEU A 184
None
1.27A 5kxiD-1yw6A:
0.0
5kxiE-1yw6A:
undetectable
5kxiD-1yw6A:
21.24
5kxiE-1yw6A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 ASP A 145
GLY A  86
GLY A  51
HIS A  53
None
0.92A 5n9xA-1yw6A:
undetectable
5n9xA-1yw6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 6 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.89A 5w97C-1yw6A:
undetectable
5w97J-1yw6A:
undetectable
5w97C-1yw6A:
20.54
5w97J-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 5 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.83A 5x1fC-1yw6A:
undetectable
5x1fJ-1yw6A:
undetectable
5x1fC-1yw6A:
20.54
5x1fJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 5 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.88A 5xdxC-1yw6A:
undetectable
5xdxJ-1yw6A:
undetectable
5xdxC-1yw6A:
20.30
5xdxJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 ILE A  48
LEU A 144
THR A 148
LEU A 211
None
0.98A 5xdxA-1yw6A:
undetectable
5xdxJ-1yw6A:
undetectable
5xdxA-1yw6A:
20.62
5xdxJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 5 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.93A 5xdxP-1yw6A:
undetectable
5xdxW-1yw6A:
undetectable
5xdxP-1yw6A:
20.30
5xdxW-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 LEU A 184
PHE A 158
LEU A 176
PHE A 172
None
0.88A 5z84C-1yw6A:
undetectable
5z84J-1yw6A:
undetectable
5z84C-1yw6A:
20.54
5z84J-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 ILE A  48
LEU A 144
THR A 148
LEU A 211
None
0.98A 5zcqA-1yw6A:
undetectable
5zcqJ-1yw6A:
undetectable
5zcqA-1yw6A:
20.62
5zcqJ-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 ARG A 250
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
0.89A 6dj1B-1yw6A:
undetectable
6dj1B-1yw6A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
5 / 12 ARG A 250
GLY A 180
ALA A 179
GLY A 242
ILE A 243
None
0.93A 6dj2B-1yw6A:
undetectable
6dj2B-1yw6A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli)
4 / 7 ILE A  48
LEU A 144
THR A 148
LEU A 211
None
0.92A 6nmpA-1yw6A:
0.0
6nmpJ-1yw6A:
undetectable
6nmpA-1yw6A:
20.62
6nmpJ-1yw6A:
11.73