SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ywf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3001_1
(SERUM ALBUMIN)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 11 ARG A  41
LEU A  44
LEU A 157
HIS A 159
ALA A   9
 None
 1.36A 1hk1A-1ywfA:
1.3		 1hk1A-1ywfA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 6 ALA A  16
LEU A 275
LEU A 175
LEU A 150
 None
 0.89A 1mt1D-1ywfA:
undetectable
1mt1E-1ywfA:
undetectable		 1mt1D-1ywfA:
17.33
1mt1E-1ywfA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 190
GLY A 233
ASP A 165
TYR A 189
 None
None
PO4  A 277 (-3.4A)
None
 1.50A 1oxrA-1ywfA:
undetectable		 1oxrA-1ywfA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 12 SER A 192
LEU A 175
VAL A 174
VAL A  15
THR A  18
 None
 1.29A 1q23B-1ywfA:
undetectable		 1q23B-1ywfA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 11 SER A 192
LEU A 175
VAL A 174
VAL A  15
THR A  18
 None
 1.26A 1q23F-1ywfA:
undetectable		 1q23F-1ywfA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		6 / 11 GLY A 261
ALA A 260
ASP A 259
ILE A 246
GLY A 254
VAL A 174
 None
 1.26A 2aquB-1ywfA:
undetectable		 2aquB-1ywfA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 260
LEU A 143
ALA A 139
PHE A 169
 None
 0.97A 2vcvA-1ywfA:
undetectable		 2vcvA-1ywfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 260
LEU A 143
ALA A 139
PHE A 169
 None
 0.89A 2vcvF-1ywfA:
undetectable		 2vcvF-1ywfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 260
LEU A 143
ALA A 139
PHE A 169
 None
 0.84A 2vcvG-1ywfA:
undetectable		 2vcvG-1ywfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 260
LEU A 143
ALA A 139
PHE A 169
 None
 0.96A 2vcvL-1ywfA:
undetectable		 2vcvL-1ywfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 7 PHE A 222
ARG A 235
MET A 126
THR A 127
 None
 1.19A 2zxwN-1ywfA:
undetectable
2zxwW-1ywfA:
undetectable		 2zxwN-1ywfA:
20.50
2zxwW-1ywfA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		3 / 3 SER A 192
GLY A 163
GLY A 168
 None
PO4  A 277 (-4.1A)
None
 0.45A 3bogA-1ywfA:
undetectable
3bogC-1ywfA:
undetectable		 3bogA-1ywfA:
undetectable
3bogC-1ywfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 261
ALA A 260
ASP A 259
GLY A 254
VAL A 174
 None
 1.03A 3cyxA-1ywfA:
undetectable		 3cyxA-1ywfA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 9 ARG A  56
ASP A  82
ALA A  84
ASP A  85
LEU A 215
 None
 1.07A 3em4B-1ywfA:
undetectable		 3em4B-1ywfA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 8 GLY A 261
ALA A 260
ASP A 259
GLY A 254
VAL A 170
 None
 1.37A 3em6A-1ywfA:
undetectable		 3em6A-1ywfA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 8 GLY A 261
ALA A 260
ASP A 259
GLY A 254
VAL A 174
 None
 1.06A 3em6A-1ywfA:
undetectable		 3em6A-1ywfA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 261
ALA A 260
ASP A 259
ILE A 246
GLY A 254
VAL A 174
 None
 1.13A 3k4vA-1ywfA:
undetectable		 3k4vA-1ywfA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 178
VAL A 170
ILE A 262
ARG A  26
 None
 1.12A 3ms9A-1ywfA:
undetectable		 3ms9A-1ywfA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 178
VAL A 170
ILE A 262
ARG A  26
 None
 0.81A 3ms9B-1ywfA:
undetectable		 3ms9B-1ywfA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 261
ALA A 260
ASP A 259
ILE A 246
GLY A 254
VAL A 174
 None
 1.16A 3ndtA-1ywfA:
undetectable		 3ndtA-1ywfA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		6 / 11 GLY A 261
ALA A 260
ASP A 259
ILE A 246
GLY A 254
VAL A 174
 None
 1.17A 3ndxB-1ywfA:
undetectable		 3ndxB-1ywfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 262
PHE A 169
LEU A 180
GLU A 176
GLY A 168
 None
 1.06A 3nxuB-1ywfA:
undetectable		 3nxuB-1ywfA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 178
VAL A 170
ILE A 262
ARG A  26
 None
 0.96A 3pyyA-1ywfA:
undetectable		 3pyyA-1ywfA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 261
ALA A 260
ASP A 259
GLY A 254
VAL A 174
 None
 1.01A 3tkgC-1ywfA:
undetectable		 3tkgC-1ywfA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 261
ALA A 260
ASP A 259
ILE A 246
GLY A 254
VAL A 174
 None
 1.24A 3tl9A-1ywfA:
undetectable		 3tl9A-1ywfA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  70
VAL A  75
HIS A  76
 None
 0.79A 4pevC-1ywfA:
2.6		 4pevC-1ywfA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		6 / 11 GLY A 261
ALA A 260
ASP A 259
ILE A 246
GLY A 254
VAL A 174
 None
 1.20A 4qgiA-1ywfA:
undetectable		 4qgiA-1ywfA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 7 GLU A   5
LEU A   6
LEU A  36
ARG A  68
LEU A  33
 None
 1.28A 4wg0B-1ywfA:
undetectable
4wg0C-1ywfA:
undetectable		 4wg0B-1ywfA:
4.90
4wg0C-1ywfA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 4 GLY A  67
VAL A  75
PHE A  28
ILE A  49
 None
 0.88A 4xv2B-1ywfA:
undetectable		 4xv2B-1ywfA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		4 / 4 LEU A 149
MET A 270
ILE A  49
LEU A  27
 None
 1.34A 5nfpA-1ywfA:
undetectable		 5nfpA-1ywfA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  15
LEU A  22
GLY A 179
LEU A 180
VAL A 174
 None
 1.23A 6czmA-1ywfA:
undetectable
6czmB-1ywfA:
undetectable		 6czmA-1ywfA:
23.20
6czmB-1ywfA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 9 VAL A  15
LEU A  22
GLY A 179
LEU A 180
VAL A 174
 None
 1.23A 6czmD-1ywfA:
undetectable
6czmE-1ywfA:
undetectable		 6czmD-1ywfA:
23.20
6czmE-1ywfA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 193
LEU A 190
GLY A 230
ASP A 229
ILE A 203
 None
 1.24A 6dwnA-1ywfA:
undetectable		 6dwnA-1ywfA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ywf PHOSPHOTYROSINE
PROTEIN PHOSPHATASE
PTPB
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  47
ASN A  11
LEU A  33
 None
 0.64A 6exiA-1ywfA:
undetectable		 6exiA-1ywfA:
15.38