SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ywg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 ASN O 319
TYR O 323
ASN O 156
TYR O 317
 NAD  O 401 (-3.6A)
NAD  O 401 (-3.7A)
None
None
 0.93A 1dssG-1ywgO:
51.3		 1dssG-1ywgO:
60.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		7 / 7 SER O 152
THR O 154
ASN O 156
CYH O 157
TYR O 317
ASN O 319
TYR O 323
 None
None
None
None
None
NAD  O 401 (-3.6A)
NAD  O 401 (-3.7A)
 0.18A 1dssG-1ywgO:
51.3		 1dssG-1ywgO:
60.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 ASN O 319
TYR O 323
ASN O 156
TYR O 317
 NAD  O 401 (-3.6A)
NAD  O 401 (-3.7A)
None
None
 0.93A 1dssR-1ywgO:
51.1		 1dssR-1ywgO:
60.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		8 / 8 SER O 152
THR O 154
ASN O 156
CYH O 157
HIS O 180
TYR O 317
ASN O 319
TYR O 323
 None
None
None
None
None
None
NAD  O 401 (-3.6A)
NAD  O 401 (-3.7A)
 0.39A 1dssR-1ywgO:
51.1		 1dssR-1ywgO:
60.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 THR O 183
GLU O 320
SER O 244
VAL O 246
 NAD  O 401 (-4.5A)
None
None
None
 1.23A 1tv8B-1ywgO:
undetectable		 1tv8B-1ywgO:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 TYR O 323
THR O 335
THR O   4
VAL O  18
 NAD  O 401 (-3.7A)
None
None
None
 1.09A 1tv8B-1ywgO:
undetectable		 1tv8B-1ywgO:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 ARG O  16
VAL O 290
THR O 242
 None
 0.67A 2nnkA-1ywgO:
undetectable		 2nnkA-1ywgO:
16.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 ASN O 319
TYR O 323
ASN O 156
TYR O 317
 NAD  O 401 (-3.6A)
NAD  O 401 (-3.7A)
None
None
 0.95A 3dmtC-1ywgO:
48.3		 3dmtC-1ywgO:
50.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		8 / 8 SER O 152
THR O 154
ASN O 156
CYH O 157
HIS O 180
TYR O 317
ASN O 319
TYR O 323
 None
None
None
None
None
None
NAD  O 401 (-3.6A)
NAD  O 401 (-3.7A)
 0.33A 3dmtC-1ywgO:
48.3		 3dmtC-1ywgO:
50.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 10 CYH O 250
VAL O 172
GLY O 170
VAL O 220
LEU O 313
 None
 1.29A 3em0A-1ywgO:
undetectable		 3em0A-1ywgO:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 LEU O 103
PRO O  82
SER O 110
GLY O  10
 None
None
None
NAD  O 401 (-3.5A)
 0.97A 3hcnA-1ywgO:
2.9		 3hcnA-1ywgO:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 7 LEU O 103
PRO O  82
SER O 110
GLY O  10
 None
None
None
NAD  O 401 (-3.5A)
 0.98A 3hcrB-1ywgO:
2.5		 3hcrB-1ywgO:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 ARG O  16
VAL O 290
THR O 242
 None
 0.65A 3k4vA-1ywgO:
undetectable		 3k4vA-1ywgO:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 ARG O  16
VAL O 290
THR O 242
 None
 0.77A 3ndtA-1ywgO:
undetectable		 3ndtA-1ywgO:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 ARG O  16
VAL O 290
THR O 242
 None
 0.76A 3nduD-1ywgO:
undetectable		 3nduD-1ywgO:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 ARG O  16
VAL O 290
THR O 242
 None
 0.68A 3pwrA-1ywgO:
undetectable		 3pwrA-1ywgO:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 ARG O  16
VAL O 290
THR O 242
 None
 0.70A 3tl9A-1ywgO:
undetectable		 3tl9A-1ywgO:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 PHE O  11
MET O  38
ILE O  33
VAL O  60
 None
 0.97A 4mk4B-1ywgO:
2.8		 4mk4B-1ywgO:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 8 LEU O 227
GLY O 221
VAL O 220
ALA O 162
GLY O 174
 None
 1.11A 4zauA-1ywgO:
undetectable		 4zauA-1ywgO:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		3 / 3 THR O 155
ALA O 151
ASN O 156
 None
 0.54A 5ersA-1ywgO:
undetectable		 5ersA-1ywgO:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE O   8
GLY O  10
THR O  99
LEU O   6
VAL O 327
 None
NAD  O 401 (-3.5A)
NAD  O 401 (-3.9A)
None
None
 1.15A 5hw4A-1ywgO:
undetectable		 5hw4A-1ywgO:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE O   8
GLY O  10
THR O  99
LEU O   6
VAL O 327
 None
NAD  O 401 (-3.5A)
NAD  O 401 (-3.9A)
None
None
 1.14A 5hw4C-1ywgO:
undetectable		 5hw4C-1ywgO:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 8 TYR O 323
SER O 152
THR O 154
PRO O 125
 NAD  O 401 (-3.7A)
None
None
None
 1.00A 5jhdE-1ywgO:
0.8
5jhdG-1ywgO:
undetectable		 5jhdE-1ywgO:
22.09
5jhdG-1ywgO:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 HIS O 291
ALA O  21
SER O 324
ARG O  13
LEU O  47
 None
 1.47A 5m54B-1ywgO:
2.4		 5m54B-1ywgO:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		5 / 12 ILE O 120
HIS O 333
ALA O 331
ILE O   8
VAL O  18
 None
 0.97A 5n0tB-1ywgO:
undetectable		 5n0tB-1ywgO:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1ywg GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Plasmodium
falciparum) 		4 / 6 PHE O  11
VAL O  74
LEU O  40
LEU O  43
 None
 1.02A 6e43D-1ywgO:
undetectable		 6e43D-1ywgO:
22.66