SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ywk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1
(Enterococcus
faecalis) 		4 / 5 PRO A1009
PRO A1221
ILE A1242
GLY A1219
 None
 1.15A 2jkjD-1ywkA:
1.5		 2jkjD-1ywkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1
(Enterococcus
faecalis) 		4 / 5 PRO A1009
PRO A1221
ILE A1242
GLY A1219
 None
 1.16A 2jkjF-1ywkA:
1.2		 2jkjF-1ywkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1
(Enterococcus
faecalis) 		5 / 10 ILE A1059
ILE A1126
LEU A1037
ASN A1000
VAL A1029
 None
 1.24A 2nnhB-1ywkA:
undetectable		 2nnhB-1ywkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1
(Enterococcus
faecalis) 		4 / 6 PHE A1024
ARG A1021
GLN A1233
ASN A1000
 None
 1.25A 2nyrA-1ywkA:
undetectable		 2nyrA-1ywkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1
(Enterococcus
faecalis) 		3 / 3 GLU A1107
HIS A1132
HIS A1133
 None
 0.87A 3co4A-1ywkA:
undetectable		 3co4A-1ywkA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1
(Enterococcus
faecalis) 		5 / 8 GLY A1077
VAL A1169
GLY A1178
ILE A1254
ILE A1140
 None
 1.19A 3ekpA-1ywkA:
undetectable		 3ekpA-1ywkA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1
(Enterococcus
faecalis) 		5 / 12 GLY A1048
GLY A1049
MET A1200
CYH A1258
ILE A1081
 None
 1.24A 3h52B-1ywkA:
undetectable		 3h52B-1ywkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1ywk 4-DEOXY-L-THREO-5-HE
XOSULOSE-URONATE
KETOL-ISOMERASE 1
(Enterococcus
faecalis) 		3 / 3 ILE A1079
ILE A1142
MET A1177
 None
 0.65A 5i9yA-1ywkA:
undetectable		 5i9yA-1ywkA:
19.76