SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yx1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  35
LEU A  27
LEU A  63
ILE A  58
LEU A  40
 None
 0.89A 1xdkF-1yx1A:
undetectable		 1xdkF-1yx1A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		5 / 9 HIS A 122
LEU A  88
LEU A  99
LEU A  80
LEU A  73
 None
 1.39A 3q1eB-1yx1A:
0.0
3q1eD-1yx1A:
0.0		 3q1eB-1yx1A:
19.39
3q1eD-1yx1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  30
SER A   7
ALA A 226
LEU A  63
 None
 1.07A 3ravA-1yx1A:
undetectable		 3ravA-1yx1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  30
SER A   7
ALA A 226
LEU A  63
 None
 1.06A 3rd0A-1yx1A:
undetectable		 3rd0A-1yx1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 185
TRP A  98
VAL A  66
LEU A  10
SER A  12
 None
 1.12A 3w68A-1yx1A:
1.8		 3w68A-1yx1A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 115
LEU A 106
GLN A 125
GLU A 150
 None
 1.19A 4i41A-1yx1A:
undetectable		 4i41A-1yx1A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 4 LEU A  29
SER A  25
LEU A  10
LEU A 236
 None
 1.08A 4n09A-1yx1A:
undetectable		 4n09A-1yx1A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 187
VAL A 186
GLU A 129
LYS A 100
 None
 1.40A 4p6vB-1yx1A:
undetectable
4p6vE-1yx1A:
undetectable		 4p6vB-1yx1A:
20.33
4p6vE-1yx1A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 6 ASN A 130
GLU A 228
GLU A  39
TYR A 185
 None
 1.19A 4twdG-1yx1A:
undetectable
4twdH-1yx1A:
undetectable		 4twdG-1yx1A:
21.93
4twdH-1yx1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_B_ADNB902_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 145
ALA A 149
VAL A 128
LEU A  99
LEU A  73
 None
 1.35A 4zmeB-1yx1A:
undetectable		 4zmeB-1yx1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  10
ARG A  90
THR A  51
LEU A  54
 None
 0.92A 5b1aA-1yx1A:
undetectable
5b1aJ-1yx1A:
undetectable		 5b1aA-1yx1A:
18.52
5b1aJ-1yx1A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  10
ARG A  90
THR A  51
LEU A  54
 None
 0.95A 5b3sA-1yx1A:
undetectable
5b3sJ-1yx1A:
undetectable		 5b3sA-1yx1A:
18.52
5b3sJ-1yx1A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 7 SER A  11
LYS A 189
HIS A 243
TYR A 185
 None
 1.38A 5dlvB-1yx1A:
0.0		 5dlvB-1yx1A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  44
ASN A 164
HIS A 187
PRO A 230
ILE A 227
 None
 1.36A 5dv4A-1yx1A:
undetectable		 5dv4A-1yx1A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 228
ALA A 226
GLU A  39
GLU A 129
 None
 1.22A 5dwkC-1yx1A:
undetectable		 5dwkC-1yx1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		5 / 8 ARG A 118
LEU A 115
LEU A  80
LEU A  99
LEU A 126
 None
 1.33A 5jqbA-1yx1A:
undetectable
5jqbB-1yx1A:
undetectable		 5jqbA-1yx1A:
21.51
5jqbB-1yx1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 163
TRP A 167
VAL A 191
TYR A 229
 None
 1.07A 5vlmA-1yx1A:
undetectable		 5vlmA-1yx1A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  10
ARG A  90
THR A  51
LEU A  54
 None
 0.95A 5zcpA-1yx1A:
undetectable
5zcpJ-1yx1A:
undetectable		 5zcpA-1yx1A:
18.52
5zcpJ-1yx1A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1yx1 HYPOTHETICAL PROTEIN
PA2260
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  10
ARG A  90
THR A  51
LEU A  54
 None
 0.94A 5zcqA-1yx1A:
undetectable
5zcqJ-1yx1A:
undetectable		 5zcqA-1yx1A:
18.52
5zcqJ-1yx1A:
13.08