SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yx5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_A_DVAA35_0
(UBIQUITIN)		 1yx5 UBIQUITIN
(Homo
sapiens) 		4 / 4 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 1.02A 2fcnA-1yx5B:
15.7		 2fcnA-1yx5B:
97.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FCN_B_DVAB35_0
(UBIQUITIN)		 1yx5 UBIQUITIN
(Homo
sapiens) 		4 / 6 GLN B  31
GLU B  34
ILE B  36
PRO B  37
 None
 0.78A 2fcnA-1yx5B:
15.7
2fcnB-1yx5B:
15.5		 2fcnA-1yx5B:
97.37
2fcnB-1yx5B:
97.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1yx5 UBIQUITIN
(Homo
sapiens) 		4 / 5 VAL B  26
LEU B  56
ILE B   3
LEU B  15
 None
 0.84A 4mghA-1yx5B:
undetectable		 4mghA-1yx5B:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1yx5 UBIQUITIN
(Homo
sapiens) 		4 / 6 ASP B  39
GLU B  24
ASP B  52
GLU B  51
 None
 1.15A 6mn5C-1yx5B:
undetectable		 6mn5C-1yx5B:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1yx5 UBIQUITIN
(Homo
sapiens) 		4 / 6 ASP B  39
GLU B  24
ASP B  52
GLU B  51
 None
 1.14A 6mn5D-1yx5B:
undetectable		 6mn5D-1yx5B:
21.57