SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yxa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		4 / 4 HIS A 114
LEU A 139
LEU A 205
LEU A 326
 None
 1.25A 1a4lD-1yxaA:
undetectable		 1a4lD-1yxaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 ALA A  81
LEU A 121
PHE A 117
ILE A 407
LEU A  47
 None
 1.21A 1ddrB-1yxaA:
undetectable		 1ddrB-1yxaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 ALA A  81
LEU A 121
PHE A 117
ILE A 407
LEU A  47
 None
 1.22A 1dreA-1yxaA:
undetectable		 1dreA-1yxaA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 PHE A  54
ILE A  78
VAL A 355
LEU A 205
ILE A  97
 None
 0.95A 1epbA-1yxaA:
undetectable		 1epbA-1yxaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 PHE A  54
ILE A  78
VAL A 355
LEU A 205
ILE A  97
 None
 0.88A 1epbB-1yxaA:
undetectable		 1epbB-1yxaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 11 ALA A  81
LEU A 121
PHE A 117
ILE A 407
LEU A  47
 None
 1.22A 1jomA-1yxaA:
undetectable		 1jomA-1yxaA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 11 PRO A 277
LEU A 397
THR A 293
VAL A 285
SER A 288
 None
 1.33A 2z9wA-1yxaA:
undetectable		 2z9wA-1yxaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 11 PRO A 277
LEU A 397
THR A 293
VAL A 285
SER A 288
 None
 1.35A 2z9wB-1yxaA:
undetectable		 2z9wB-1yxaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 11 PRO A 277
LEU A 397
THR A 293
VAL A 285
SER A 288
 None
 1.37A 2z9xB-1yxaA:
undetectable		 2z9xB-1yxaA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		4 / 5 ILE A  78
SER A  74
PRO A  75
PRO A 409
 None
 1.32A 3bjwC-1yxaA:
undetectable		 3bjwC-1yxaA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		4 / 5 TYR A 181
ILE A 344
LEU A 139
PHE A 140
 None
 1.27A 3ls4L-1yxaA:
undetectable		 3ls4L-1yxaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		4 / 7 TYR A  59
VAL A 356
VAL A 325
ILE A  78
 None
 1.23A 3ms9B-1yxaA:
undetectable		 3ms9B-1yxaA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 ALA A  81
LEU A 121
PHE A 117
ILE A 407
LEU A  47
 None
 1.20A 3ql0A-1yxaA:
undetectable		 3ql0A-1yxaA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 PHE A 396
TYR A  59
LEU A 289
LEU A 273
MET A 399
 None
 1.44A 3vn2A-1yxaA:
undetectable		 3vn2A-1yxaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		4 / 6 GLN A 169
ARG A 144
ASP A 198
GLU A 323
 None
 1.41A 4ax8A-1yxaA:
undetectable		 4ax8A-1yxaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		4 / 6 GLN A 169
ARG A 144
ASP A 198
GLU A 323
 None
 1.42A 4azvA-1yxaA:
undetectable		 4azvA-1yxaA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 ALA A  81
LEU A 121
PHE A 117
ILE A 407
LEU A  47
 None
 1.10A 4ej1B-1yxaA:
undetectable		 4ej1B-1yxaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 11 ALA A  81
LEU A 121
PHE A 117
ILE A 407
LEU A  47
 None
 1.19A 4qlfA-1yxaA:
undetectable		 4qlfA-1yxaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 ALA A  81
LEU A 121
PHE A 117
ILE A 407
LEU A  47
 None
 1.16A 4qlgA-1yxaA:
undetectable		 4qlgA-1yxaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 ALA A  81
LEU A 121
PHE A 117
ILE A 407
LEU A  47
 None
 1.15A 5e8qB-1yxaA:
undetectable		 5e8qB-1yxaA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 10 ILE A  97
GLY A 100
LEU A 101
LEU A 326
LEU A  58
 None
 1.33A 5fhzC-1yxaA:
undetectable		 5fhzC-1yxaA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 MET A 203
ILE A 147
LEU A 139
LEU A  84
VAL A  85
 None
 1.22A 5im2A-1yxaA:
undetectable		 5im2A-1yxaA:
23.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		4 / 6 LEU A  58
SER A  57
PHE A  54
ASP A  53
 None
 1.07A 5om3A-1yxaA:
37.4
5om3B-1yxaA:
undetectable		 5om3A-1yxaA:
51.22
5om3B-1yxaA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		4 / 6 GLU A 286
ALA A 287
LEU A 289
TYR A  59
 None
 1.14A 5phhA-1yxaA:
undetectable		 5phhA-1yxaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		4 / 7 ILE A 407
LEU A 120
LEU A 121
PRO A 409
 None
 0.99A 5u4sA-1yxaA:
undetectable		 5u4sA-1yxaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 ALA A  81
LEU A 121
PHE A 117
ILE A 407
LEU A  47
 None
 1.14A 5ujxB-1yxaA:
undetectable		 5ujxB-1yxaA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		3 / 3 SER A  86
HIS A 114
TYR A 159
 None
 1.02A 5y2tA-1yxaA:
undetectable		 5y2tA-1yxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1yxa SERINE (OR CYSTEINE)
PROTEINASE
INHIBITOR, CLADE A,
MEMBER 3N
(Mus
musculus) 		5 / 12 ILE A 113
ALA A  83
ILE A  50
ALA A  80
LEU A 105
 None
 1.15A 6a5zD-1yxaA:
undetectable		 6a5zD-1yxaA:
14.73