SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		4 / 8 LEU A 104
THR A  94
VAL A  91
ALA A  48
 None
 0.80A 1fiqC-1yxmA:
undetectable		 1fiqC-1yxmA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		4 / 8 ARG A 175
SER A 171
VAL A 159
ASN A 107
 None
 1.07A 1hwiB-1yxmA:
undetectable		 1hwiB-1yxmA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A  58
GLY A  25
GLY A  29
ALA A  48
LEU A  90
 None
 1.01A 2plwA-1yxmA:
8.8		 2plwA-1yxmA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A  25
GLY A  29
ILE A  81
ALA A  48
LEU A  90
 None
 1.01A 2plwA-1yxmA:
8.8		 2plwA-1yxmA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 10 THR A  28
ILE A  30
GLY A  31
GLY A 108
PRO A 201
 None
 0.98A 2y7pA-1yxmA:
undetectable		 2y7pA-1yxmA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		4 / 8 LEU A 104
THR A  94
VAL A  91
ALA A  48
 None
 0.85A 3ax9A-1yxmA:
undetectable		 3ax9A-1yxmA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		4 / 7 GLY A 110
MET A 138
CYH A 139
GLY A  25
 None
 0.95A 3ko0M-1yxmA:
undetectable
3ko0P-1yxmA:
undetectable		 3ko0M-1yxmA:
16.10
3ko0P-1yxmA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		4 / 8 GLY A 110
MET A 138
CYH A 139
GLY A  25
 None
 0.97A 3ko0O-1yxmA:
undetectable
3ko0Q-1yxmA:
undetectable		 3ko0O-1yxmA:
16.10
3ko0Q-1yxmA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLU A  40
SER A   9
GLU A 237
VAL A 239
ASN A 107
 None
 1.24A 3rfaA-1yxmA:
0.8		 3rfaA-1yxmA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		4 / 5 ILE A  75
THR A  97
THR A  94
SER A  93
 None
 0.93A 3snfA-1yxmA:
undetectable		 3snfA-1yxmA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		4 / 5 LEU A  11
PHE A 245
PRO A 249
ALA A 251
 None
 1.24A 3vm4A-1yxmA:
undetectable		 3vm4A-1yxmA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 11 ILE A  34
ILE A  30
GLY A  29
VAL A 261
GLY A 234
 None
 1.03A 4ac9B-1yxmA:
6.8
4ac9C-1yxmA:
6.6		 4ac9B-1yxmA:
22.04
4ac9C-1yxmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 108
GLY A 109
THR A  24
ILE A  47
GLY A  31
 None
 0.96A 4n48A-1yxmA:
7.4		 4n48A-1yxmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 108
GLY A 109
THR A  24
ILE A  47
GLY A  31
 None
 0.96A 4n48B-1yxmA:
7.6		 4n48B-1yxmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		4 / 7 VAL A 243
PHE A 103
VAL A 105
ILE A 157
 None
 0.80A 5bmvC-1yxmA:
7.2		 5bmvC-1yxmA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 8 ILE A  81
GLY A 108
PHE A  98
ASN A 156
PHE A 103
 None
 1.41A 5hieD-1yxmA:
undetectable		 5hieD-1yxmA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 9 ALA A  27
GLY A 108
ILE A  81
VAL A  46
ILE A  47
 None
 1.17A 5kr0A-1yxmA:
undetectable		 5kr0A-1yxmA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 1yxm PEROXISOMAL TRANS
2-ENOYL COA
REDUCTASE
(Homo
sapiens) 		5 / 12 LEU A 128
SER A 171
GLY A 172
GLY A 177
VAL A 178
 None
 1.34A 5o4yD-1yxmA:
undetectable
5o4yE-1yxmA:
undetectable		 5o4yD-1yxmA:
3.83
5o4yE-1yxmA:
17.92