SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		4 / 5 HIS A1135
LEU A1313
LEU A1040
GLY A1016
 None
 1.11A 1a4lB-1yxoA:
undetectable		 1a4lB-1yxoA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1152
ALA A1160
HIS A1188
LEU A1187
ALA A1153
 EOH  A3000 ( 4.9A)
None
None
None
None
 1.04A 1bzfA-1yxoA:
undetectable		 1bzfA-1yxoA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1272
ALA A1280
THR A1319
VAL A1315
LEU A1187
 None
 1.07A 1cbsA-1yxoA:
undetectable		 1cbsA-1yxoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 11 LEU A1180
ALA A1160
VAL A1224
MET A1263
ARG A1233
 None
 1.43A 1kt6A-1yxoA:
undetectable		 1kt6A-1yxoA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 11 LEU A1180
ALA A1160
VAL A1224
MET A1263
ARG A1233
 None
 1.43A 1kt7A-1yxoA:
undetectable		 1kt7A-1yxoA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		3 / 3 LEU A1180
VAL A1183
LEU A1187
 None
 0.43A 1mz9B-1yxoA:
undetectable		 1mz9B-1yxoA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1272
ALA A1280
THR A1319
VAL A1315
LEU A1187
 None
 1.14A 2g78A-1yxoA:
undetectable		 2g78A-1yxoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 12 LEU A1272
ALA A1280
THR A1319
VAL A1315
LEU A1191
 None
 1.16A 2g78A-1yxoA:
undetectable		 2g78A-1yxoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		6 / 12 LEU A1032
ALA A1034
ALA A1036
VAL A1096
THR A1099
GLU A1011
 None
 1.37A 3cwkA-1yxoA:
undetectable		 3cwkA-1yxoA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		4 / 4 LEU A1108
GLY A1106
GLY A1104
THR A1101
 None
 0.94A 3si7A-1yxoA:
undetectable		 3si7A-1yxoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 9 VAL A1096
GLY A1014
ILE A1015
PRO A1009
THR A1008
 None
 1.27A 3spkA-1yxoA:
undetectable		 3spkA-1yxoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 11 ALA A1036
LEU A1040
GLY A1014
VAL A1096
GLY A1016
 None
 0.78A 3zosA-1yxoA:
undetectable
3zosB-1yxoA:
undetectable		 3zosA-1yxoA:
24.22
3zosB-1yxoA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		4 / 8 PHE A1005
HIS A1030
GLU A1318
ILE A1116
 None
 1.27A 4cx7A-1yxoA:
undetectable
4cx7B-1yxoA:
undetectable		 4cx7A-1yxoA:
22.25
4cx7B-1yxoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A1125
ALA A1093
ALA A1013
LEU A1088
PHE A1132
 None
 1.14A 4lnwA-1yxoA:
undetectable		 4lnwA-1yxoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 12 ILE A1125
ALA A1093
ALA A1013
LEU A1088
PHE A1132
 None
 1.14A 4lnxA-1yxoA:
undetectable		 4lnxA-1yxoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 10 LEU A1048
LEU A1022
LEU A1023
ARG A1044
HIS A1296
 None
 0.97A 4mk4A-1yxoA:
3.6		 4mk4A-1yxoA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		4 / 4 LEU A1317
SER A1293
LEU A1019
LEU A1032
 None
 1.06A 4n09A-1yxoA:
undetectable		 4n09A-1yxoA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		4 / 7 LEU A1041
ALA A1036
ALA A1118
ALA A1034
 None
 0.63A 4z90F-1yxoA:
undetectable
4z90G-1yxoA:
undetectable
4z90H-1yxoA:
undetectable
4z90J-1yxoA:
undetectable		 4z90F-1yxoA:
22.74
4z90G-1yxoA:
22.74
4z90H-1yxoA:
22.74
4z90J-1yxoA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 11 THR A1099
SER A1037
ALA A1081
GLU A1011
GLY A1016
 None
EOH  A3007 ( 4.8A)
None
None
None
 1.24A 4zjoD-1yxoA:
undetectable		 4zjoD-1yxoA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		4 / 8 LEU A1040
THR A1099
ILE A1035
ALA A1034
 None
 0.69A 5te8B-1yxoA:
undetectable		 5te8B-1yxoA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		4 / 7 LEU A1100
ARG A1291
VAL A1148
GLU A1137
 None
 1.26A 5umwA-1yxoA:
0.3
5umwF-1yxoA:
undetectable		 5umwA-1yxoA:
13.70
5umwF-1yxoA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		6 / 12 GLN A1047
PRO A1085
THR A1099
GLY A1010
GLY A1016
ASP A1018
 None
 1.32A 6b69A-1yxoA:
undetectable
6b69B-1yxoA:
undetectable		 6b69A-1yxoA:
15.28
6b69B-1yxoA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 12 HIS A1296
SER A1312
THR A1117
ALA A1118
ALA A1316
 None
 1.24A 6hwdV-1yxoA:
undetectable
6hwdb-1yxoA:
undetectable		 6hwdV-1yxoA:
17.22
6hwdb-1yxoA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1
(Pseudomonas
aeruginosa) 		5 / 12 HIS A1296
SER A1312
THR A1117
ALA A1118
ALA A1316
 None
 1.24A 6hwdH-1yxoA:
undetectable
6hwdN-1yxoA:
undetectable		 6hwdH-1yxoA:
17.22
6hwdN-1yxoA:
13.19