SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1yxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 8 ALA A  42
GLY A  52
ILE A  19
ILE A  61
ILE A  64
 None
 0.95A 1hshD-1yxyA:
undetectable		 1hshD-1yxyA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 9 LEU A 182
GLY A 153
ILE A 124
VAL A 189
ILE A 187
 None
 0.99A 1ohrB-1yxyA:
undetectable		 1ohrB-1yxyA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 8 GLY A  52
VAL A 104
GLY A 211
ILE A 212
ILE A  73
 None
 0.99A 3ekpA-1yxyA:
undetectable		 3ekpA-1yxyA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 THR A 159
ILE A 195
ASN A 205
ILE A 212
VAL A 214
 None
 1.08A 3kpdC-1yxyA:
undetectable		 3kpdC-1yxyA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		6 / 12 LEU A 135
ILE A  73
VAL A 213
GLY A 211
PRO A  71
VAL A 104
 None
 1.09A 3ucbB-1yxyA:
undetectable		 3ucbB-1yxyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 GLY A 158
ALA A 138
ILE A 190
LEU A 161
SER A 141
 None
 0.83A 4azvA-1yxyA:
undetectable		 4azvA-1yxyA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 10 ILE A  73
VAL A 213
GLY A 211
PRO A  71
VAL A 104
 None
 1.05A 4j5jB-1yxyA:
undetectable		 4j5jB-1yxyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 190
ALA A 106
ILE A  75
ASP A 139
ILE A  19
 None
 1.13A 4km0B-1yxyA:
undetectable		 4km0B-1yxyA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 11 LEU A 182
GLY A 153
ILE A 124
VAL A 189
ILE A 187
 None
 0.85A 4qgiB-1yxyA:
undetectable		 4qgiB-1yxyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		3 / 3 THR A 165
HIS A 150
LEU A 182
 None
 0.88A 5axdC-1yxyA:
undetectable		 5axdC-1yxyA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		4 / 7 ARG A  54
GLY A 215
THR A 160
GLU A 192
 None
 0.90A 5btaA-1yxyA:
undetectable
5btaC-1yxyA:
undetectable
5btaD-1yxyA:
undetectable		 5btaA-1yxyA:
19.64
5btaC-1yxyA:
19.64
5btaD-1yxyA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		4 / 6 ARG A  54
GLY A 215
THR A 160
GLU A 192
 None
 0.87A 5btaA-1yxyA:
undetectable
5btaB-1yxyA:
undetectable
5btaC-1yxyA:
undetectable		 5btaA-1yxyA:
19.64
5btaB-1yxyA:
24.83
5btaC-1yxyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		4 / 6 ARG A  54
GLY A 215
THR A 160
GLU A 192
 None
 0.96A 5btcA-1yxyA:
undetectable
5btcC-1yxyA:
undetectable
5btcD-1yxyA:
undetectable		 5btcA-1yxyA:
19.64
5btcC-1yxyA:
19.64
5btcD-1yxyA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		4 / 6 ARG A  54
GLY A 215
THR A 160
GLU A 192
 None
 0.91A 5btcA-1yxyA:
undetectable
5btcB-1yxyA:
undetectable
5btcC-1yxyA:
undetectable		 5btcA-1yxyA:
19.64
5btcB-1yxyA:
24.83
5btcC-1yxyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		4 / 7 ARG A  54
GLY A 215
THR A 160
GLU A 192
 None
 0.92A 5btfA-1yxyA:
undetectable
5btfB-1yxyA:
undetectable
5btfC-1yxyA:
undetectable		 5btfA-1yxyA:
19.64
5btfB-1yxyA:
24.83
5btfC-1yxyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		4 / 6 ARG A  54
GLY A 215
THR A 160
GLU A 192
 None
 0.95A 5btgA-1yxyA:
undetectable
5btgB-1yxyA:
undetectable
5btgC-1yxyA:
undetectable		 5btgA-1yxyA:
19.64
5btgB-1yxyA:
24.83
5btgC-1yxyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		4 / 4 LEU A 136
ARG A 114
ILE A 124
ILE A 120
 None
 1.33A 5dzk2-1yxyA:
undetectable
5dzkM-1yxyA:
undetectable
5dzkN-1yxyA:
undetectable		 5dzk2-1yxyA:
1.47
5dzkM-1yxyA:
26.72
5dzkN-1yxyA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		4 / 4 ILE A 124
ILE A 120
ARG A 114
LEU A 136
 None
 1.26A 5dzkh-1yxyA:
undetectable
5dzkn-1yxyA:
undetectable
5dzkv-1yxyA:
undetectable		 5dzkh-1yxyA:
26.72
5dzkn-1yxyA:
26.72
5dzkv-1yxyA:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		4 / 6 ARG A 114
ARG A 112
ASP A 116
ASP A  79
 None
 1.02A 5zw4A-1yxyA:
undetectable		 5zw4A-1yxyA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 VAL A 104
GLY A 211
ILE A 212
LEU A 135
ILE A  73
 None
 0.96A 6dgxB-1yxyA:
undetectable		 6dgxB-1yxyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 1yxy PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  52
VAL A 104
GLY A 211
ILE A 212
LEU A 135
 None
 0.89A 6dh0B-1yxyA:
undetectable		 6dh0B-1yxyA:
19.27